دورية أكاديمية
أعرض في EDS

Pulmonary CT perfusion robustly measures cardiac output in the context of multilevel pulmonary occlusion: a porcine study.

التفاصيل البيبلوغرافية
العنوان: Pulmonary CT perfusion robustly measures cardiac output in the context of multilevel pulmonary occlusion: a porcine study.
المؤلفون: Silva D; Medical Information Technology (MedIT), RWTH Aachen University, Aachen, Germany., Muders T; Department of Anaesthesiology and Intensive Care Medicine, University Bonn, Bonn, Germany., Wodack K; Department of Anaesthesiology and Intensive Care Medicine, University Bonn, Bonn, Germany., Putensen C; Department of Anaesthesiology and Intensive Care Medicine, University Bonn, Bonn, Germany., Leonhardt S; Medical Information Technology (MedIT), RWTH Aachen University, Aachen, Germany., Siepmann R; Department of Diagnostic and Interventional Radiology, Uniklinik RWTH Aachen, Aachen, Germany., Hentze B; Medical Information Technology (MedIT), RWTH Aachen University, Aachen, Germany.; Department of Anaesthesiology and Intensive Care Medicine, University Bonn, Bonn, Germany., Reinartz S; Department of Diagnostic and Interventional Radiology, Uniklinik RWTH Aachen, Aachen, Germany. Sebastian.D.Reinartz@rwth-aachen.de.
المصدر: European radiology experimental [Eur Radiol Exp] 2024 Mar 22; Vol. 8 (1), pp. 51. Date of Electronic Publication: 2024 Mar 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SpringerOpen Country of Publication: England NLM ID: 101721752 Publication Model: Electronic Cited Medium: Internet ISSN: 2509-9280 (Electronic) Linking ISSN: 25099280 NLM ISO Abbreviation: Eur Radiol Exp Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London, United Kingdom] : SpringerOpen, [2017]-
مواضيع طبية MeSH: Pulmonary Artery*/diagnostic imaging , Catheterization, Swan-Ganz*/methods, Humans ; Swine ; Animals ; Cardiac Output/physiology ; Perfusion ; Tomography, X-Ray Computed
مستخلص: Background: To validate pulmonary computed tomography (CT) perfusion in a porcine model by invasive monitoring of cardiac output (CO) using thermodilution method.
Methods: Animals were studied at a single center, using a Swan-Ganz catheter for invasive CO monitoring as a reference. Fifteen pigs were included. Contrast-enhanced CT perfusion of the descending aorta and right and left pulmonary artery was performed. For variation purposes, a balloon catheter was inserted to block the contralateral pulmonary vascular bed; additionally, two increased CO settings were created by intravenous administration of catecholamines. Finally, stepwise capillary occlusion was performed by intrapulmonary arterial injection of 75-μm microspheres in four stages. A semiautomatic selection of AFs and a recirculation-aware tracer-kinetics model to extract the first-pass of AFs, estimating blood flow with the Stewart-Hamilton method, was implemented. Linear mixed models (LMM) were developed to calibrate blood flow calculations accounting with individual- and cohort-level effects.
Results: Nine of 15 pigs had complete datasets. Strong correlations were observed between calibrated pulmonary (0.73, 95% confidence interval [CI] 0.6-0.82) and aortic blood flow measurements (0.82, 95% CI, 0.73-0.88) and the reference as well as agreements (± 2.24 L/min and ± 1.86 L/min, respectively) comparable to the state of the art, on a relatively wide range of right ventricle-CO measurements.
Conclusions: CT perfusion validly measures CO using LMMs at both individual and cohort levels, as demonstrated by referencing the invasive CO.
Relevance Statement: Possible clinical applications of CT perfusion for measuring CO could be in acute pulmonary thromboembolism or to assess right ventricular function to show impairment or mismatch to the left ventricle.
Key Points: • CT perfusion measures flow in vessels. • CT perfusion measures cumulative cardiac output in the aorta and pulmonary vessels. • CT perfusion validly measures CO using LMMs at both individual and cohort levels, as demonstrated by using the invasive CO as a reference standard.
(© 2024. The Author(s).)
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معلومات مُعتمدة: LE 817/40-1 Deutsche Forschungsgesellschaft; RE 4418/1-1 Deutsche Forschungsgesellschaft; PU 219/2-3 Deutsche Forschungsgesellschaft
فهرسة مساهمة: Keywords: Cardiac output; Heart ventricles; Perfusion; Pulmonary artery; Tomography (x-ray computed)
تواريخ الأحداث: Date Created: 20240322 Date Completed: 20240325 Latest Revision: 20240325
رمز التحديث: 20240325
مُعرف محوري في PubMed: PMC10959917
DOI: 10.1186/s41747-024-00431-7
PMID: 38517595
قاعدة البيانات: MEDLINE
الوصف
تدمد:2509-9280
DOI:10.1186/s41747-024-00431-7