دورية أكاديمية
The effect of Argania spinosa seed oil on diabetic nephropathy in streptozotocin-induced diabetes in Wistar rats.
| العنوان: | The effect of Argania spinosa seed oil on diabetic nephropathy in streptozotocin-induced diabetes in Wistar rats. |
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| المؤلفون: | Daoudi NE; Higher Institute of Nursing Professions and Health Techniques, Oujda, 60000, Morocco; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Boulevard Mohamed VI, BP: 717, 60 000, Oujda, Morocco. Electronic address: n.daoudi@ump.ac.ma., El Assri S; Biochemistry Laboratory, Central Laboratory Service - CHU, Mohammed VI, Oujda, Morocco., Aziz M; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Boulevard Mohamed VI, BP: 717, 60 000, Oujda, Morocco., Choukri M; Biochemistry Laboratory, Central Laboratory Service - CHU, Mohammed VI, Oujda, Morocco., Mekhfi H; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Boulevard Mohamed VI, BP: 717, 60 000, Oujda, Morocco., Legssyer A; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Boulevard Mohamed VI, BP: 717, 60 000, Oujda, Morocco., Ziyyat A; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Boulevard Mohamed VI, BP: 717, 60 000, Oujda, Morocco., Bnouham M; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Boulevard Mohamed VI, BP: 717, 60 000, Oujda, Morocco. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2024 Jun 28; Vol. 328, pp. 118083. Date of Electronic Publication: 2024 Mar 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Diabetic Nephropathies*/drug therapy , Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/drug therapy , Sapotaceae*, Humans ; Rats ; Animals ; Rats, Wistar ; Streptozocin ; Plant Oils/pharmacology ; Plant Oils/therapeutic use |
| مستخلص: | Ethnopharmacological Relevance: Diabetes is a significant metabolic disease impacting many of the world's population. In Morocco, a wide range of medicinal plants has taken great importance in the treatment of diabetes, among these plants; we find Argania spinosa (L.) Skeels. Aim: The objective of our work is based on the evaluation of the effect of roasted (Roil) and unroasted (UnRoil) Argan seed oil on diabetic nephropathy. Materials and Methods: Roasted and unroasted oils from Argania spinosa (L.) Skeels seeds were examined for their effects on diabetic nephropathy using an experimental streptozotocin-induced model. Biochemical and histopathological analyses were conducted on blood and kidney samples to assess renal function and tissue damage. Results: Both oils ameliorated significantly diabetic nephropathy symptoms. They limited the renal damage caused by streptozotocin and improved diabetes symptoms, including blood glucose levels, body weight, water intake, urinary volume, and kidney parameters. This activity could be elucidated by the antioxidant effect of Argan oil, enabling to neutralize free radicals and undertake a fundamental role in preventing the onset of these complications. Conclusion: Based on our findings, Argan oil could be used as dietary supplement for people with diabetes as a preventive measure against the emergence of diabetic complications. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antioxidants; Argania spinosa (L.) skeels; Diabetes; Diabetic nephropathy; Roasting process |
| المشرفين على المادة: | 5W494URQ81 (Streptozocin) 0 (Plant Oils) |
| تواريخ الأحداث: | Date Created: 20240323 Date Completed: 20240415 Latest Revision: 20240415 |
| رمز التحديث: | 20240415 |
| DOI: | 10.1016/j.jep.2024.118083 |
| PMID: | 38521428 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2024.118083 |