دورية أكاديمية
Antihyperglycemic and antihyperlipidemic effects of fruit extract of Hodgsonia heteroclita (Roxb.) Hook. f. & Thomson in diabetic mice.
| العنوان: | Antihyperglycemic and antihyperlipidemic effects of fruit extract of Hodgsonia heteroclita (Roxb.) Hook. f. & Thomson in diabetic mice. |
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| المؤلفون: | Basumatary S; Laboratory of Ethnobotany and Medicinal Plants Conservation, Department of Ecology and Environmental Science, Assam University, Silchar, 788011, India., Adhikari PP; Laboratory of Natural Product and Synthetic Organic Chemistry, Department of Chemistry, Assam University, Silchar, 788011, India; Genoine Research Laboratory Pvt. Ltd., Subhash Nagar, Karimganj, 788710, Assam, India., Das AK; Laboratory of Ethnobotany and Medicinal Plants Conservation, Department of Ecology and Environmental Science, Assam University, Silchar, 788011, India., Raaman N; Center for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, 600025, India., Sharma GD; Department of Life Science and Bioinformatics, Assam University, Silchar, 788011, India; Bilaspur Vishwavidyalaya, Bilaspur, 495001, Chhattisgarh, India., Sarmah J; Department of Biotechnology, Bodoland University, Assam, 783370, India., Dihingia A; Centre for Infectious Diseases, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India., Baishya R; Centre for Preclinical Studies, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India., Manna P; Centre for Infectious Diseases, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India. Electronic address: pmanna2012@gmail.com., Kalita J; Centre for Infectious Diseases, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India. Electronic address: kalitajk74@gmail.com. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2024 Jun 28; Vol. 328, pp. 118094. Date of Electronic Publication: 2024 Mar 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Diabetes Mellitus, Experimental*/drug therapy , Cucurbitaceae* , Triterpenes*/pharmacology, Mice ; Animals ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/analysis ; Hypolipidemic Agents/pharmacology ; Hypolipidemic Agents/therapeutic use ; Hypolipidemic Agents/analysis ; Blood Glucose ; Fruit/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry ; Ethanol/chemistry ; Liver Glycogen ; Cholesterol/pharmacology ; Body Weight ; Streptozocin/pharmacology |
| مستخلص: | Ethnopharmacological Relevance: Hodgsonia heteroclita has been known as an important traditionally consumed medicinal plant of North-East India known to have antidiabetic properties. This study aims to investigate the effects of the ethanolic fruit extract of Hodgsonia heteroclita against hyperglycemia and hyperlipidemia by using streptozotocin (STZ) treated diabetic mice. Materials and Methods: The fruits of H. heteroclita were collected from the various parts of Kokrajhar district, Assam India (Geographic coordinates: 26°24'3.85″ N 90°16'22.30″ E). Basic morphological evaluations were carried out by the Botanical Survey of India, Eastern circle, Shillong, who also certified and identified the plant. Hexane, chloroform, and ethanolic extracts of the fruit of H. heteroclita were investigated for α-amylase inhibition assay as a rapid screening tool for examining anti-diabetic activity. The efficacy of ethanolic extract at a dose of 100, 200, and 300 mg/kg body weight was tested for 21 days in STZ-induced diabetic mice. The body weight, fasting plasma glucose and serum lipids, and hepatic glycogen levels were measured in experimental animals to examine the antihyperglycemic and antihyperlipidemic efficacy of the extract. Both HPTLC and LC-MS analysis was performed to examine the phyotochemicals present in the ethanolic extract of H. heteroclita. Results: It has been observed that treatment with the ethanolic extract dose-dependently reduced the plasma glucose levels, total cholesterol, low density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol, triglyceride, and increased the body weight, liver glycogens and high-density lipoprotein-cholesterol in STZ treated diabetic mice. HPTLC demonstrated the presence of triterpene compounds and LC-MS analysis revealed the presence Cucurbitacin I, Cucurbitacin E, and Kuguacin G as the triterpene phytoconstituents. Conclusion: The present study demonstrated that ethanolic fruit extract of H. heteroclita improved both glycemic and lipid parameters in mice model of diabetes. Competing Interests: Declaration of competing interest None. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-hyperglycemia; Anti-hyperlipidemia; Diabetes mellitus; Fruits of Hodgsonia heteroclita; α-amylase inhibition |
| المشرفين على المادة: | 0 (Hypoglycemic Agents) 0 (Hypolipidemic Agents) 0 (Blood Glucose) 0 (Plant Extracts) 3K9958V90M (Ethanol) 0 (Liver Glycogen) 97C5T2UQ7J (Cholesterol) 0 (Triterpenes) 5W494URQ81 (Streptozocin) |
| تواريخ الأحداث: | Date Created: 20240323 Date Completed: 20240415 Latest Revision: 20240415 |
| رمز التحديث: | 20240415 |
| DOI: | 10.1016/j.jep.2024.118094 |
| PMID: | 38521433 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2024.118094 |