دورية أكاديمية
Stabilization of interdomain interactions in G protein α subunits as a determinant of Gα i subtype signaling specificity.
العنوان: | Stabilization of interdomain interactions in G protein α subunits as a determinant of Gα |
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المؤلفون: | Lefevre TJ; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, USA., Wei W; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA., Mukhaleva E; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA., Meda Venkata SP; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Chandan NR; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Genentech, South San Francisco, California, USA., Abraham S; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Li Y; Department of Integrative Biology and Pharmacology McGovern Medical School, UTHealth, Houston, Texas, USA., Dessauer CW; Department of Integrative Biology and Pharmacology McGovern Medical School, UTHealth, Houston, Texas, USA., Vaidehi N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA., Smrcka AV; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: avsmrcka@umich.edu. |
المصدر: | The Journal of biological chemistry [J Biol Chem] 2024 May; Vol. 300 (5), pp. 107211. Date of Electronic Publication: 2024 Mar 22. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology |
مواضيع طبية MeSH: | GTP-Binding Protein alpha Subunits, Gi-Go*/metabolism , GTP-Binding Protein alpha Subunits, Gi-Go*/chemistry , GTP-Binding Protein alpha Subunits, Gi-Go*/genetics , Signal Transduction*, Humans ; Molecular Dynamics Simulation ; GTP-Binding Protein alpha Subunit, Gi2/metabolism ; GTP-Binding Protein alpha Subunit, Gi2/genetics ; GTP-Binding Protein alpha Subunit, Gi2/chemistry ; HEK293 Cells ; Protein Domains ; Protein Stability ; Protein Binding |
مستخلص: | Highly homologous members of the Gα Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
التعليقات: | Update of: bioRxiv. 2023 Apr 06:2023.03.10.532072. doi: 10.1101/2023.03.10.532072. (PMID: 37066214) |
معلومات مُعتمدة: | R35 GM127303 United States GM NIGMS NIH HHS |
فهرسة مساهمة: | Keywords: G protein–coupled receptor; Rho GEF; alpha subunits; domain interactions; effector coupling; heterotrimeric G protein; mass spectrometry; proximity labeling; structure |
المشرفين على المادة: | EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gi-Go) EC 3.6.5.1 (GTP-Binding Protein alpha Subunit, Gi2) |
تواريخ الأحداث: | Date Created: 20240324 Date Completed: 20240529 Latest Revision: 20240611 |
رمز التحديث: | 20240612 |
مُعرف محوري في PubMed: | PMC11066577 |
DOI: | 10.1016/j.jbc.2024.107211 |
PMID: | 38522511 |
قاعدة البيانات: | MEDLINE |
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