دورية أكاديمية
Research gap in esophageal achalasia: a narrative review.
| العنوان: | Research gap in esophageal achalasia: a narrative review. |
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| المؤلفون: | Savarino EV; Gastroenterology Unit, Azienda Ospedale Università of Padua, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy., Salvador R; Chirurgia Generale 1, Azienda Ospedale Università of Padua, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy., Ghisa M; Gastroenterology Unit, Azienda Ospedale Università of Padua, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy., Mari A; Gastroenterology Unit, Nazareth Hospital EMMS, The Azrieli Faculty of Medicine, Bar-Ilan University, Tel Aviv, Israel., Forattini F; Chirurgia Generale 1, Azienda Ospedale Università of Padua, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy., Costantini A; Chirurgia Generale 1, Azienda Ospedale Università of Padua, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy., De Giorgio R; Department of Translational Medicine, University of Ferrara, Ferrara, Italy., Zaninotto G; Department of Surgery and Cancer, Imperial College London, UK. |
| المصدر: | Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [Dis Esophagus] 2024 Jul 31; Vol. 37 (8). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 8809160 Publication Model: Print Cited Medium: Internet ISSN: 1442-2050 (Electronic) Linking ISSN: 11208694 NLM ISO Abbreviation: Dis Esophagus Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Milano : Masson, 1988- |
| مواضيع طبية MeSH: | Esophageal Achalasia*/diagnosis , Esophageal Achalasia*/therapy , Esophageal Achalasia*/physiopathology , Chest Pain*/etiology, Humans ; Manometry/methods ; Evidence Gaps |
| مستخلص: | In recent years, new translational evidence, diagnostic techniques, and innovative therapies have shed new light on esophageal achalasia and revamped the attention on this relatively rare motility disorder. This narrative review aims to highlight the most recent progress and the areas where further research is needed. The four senior authors identified five topics commonly discussed in achalasia management: i.e. pathogenesis, role of functional lumen imaging probe in the diagnostic flow chart of achalasia, how to define the outcome of achalasia treatments, how to manage persistent chest pain after the treatment, and if achalasia patients' may benefit from a regular follow-up. We searched the bibliographic databases to identify systematic reviews, meta-analyses, randomized control trials, and original research articles in English up to December 2023. We provide a summary with the most recent findings in each of the five topics and the critical points where to address future research, such as the immune-genetic patterns of achalasia that might explain the transition among the different phenotypes, the need for a validated clinical definition of treatment success, the use of neuromodulators to manage chest pain, and the need for identifying achalasia patients at risk for cancer and who may benefit of long-term follow-up. Although undoubtedly, progress has been made on the definition and management of achalasia, unmet needs remain. Debated aspects range from mechanistic insights, symptoms, objective measure relationships, and accurate clinical responses to therapeutic interventions. Translational research is eagerly awaited to answer these unresolved questions. (© The Author(s) 2024. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| تواريخ الأحداث: | Date Created: 20240325 Date Completed: 20240801 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| DOI: | 10.1093/dote/doae024 |
| PMID: | 38525929 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1442-2050 |
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| DOI: | 10.1093/dote/doae024 |