دورية أكاديمية
أعرض في EDS

Very low serum IGF-1 levels are associated with vertebral fractures in adult males with beta-thalassemia major.

التفاصيل البيبلوغرافية
العنوان: Very low serum IGF-1 levels are associated with vertebral fractures in adult males with beta-thalassemia major.
المؤلفون: Costanzo G; Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, 95122, Catania, Italy., Naselli A; Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, 95122, Catania, Italy., Arpi ML; Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, 95122, Catania, Italy., Piticchio T; Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, 95122, Catania, Italy., Le Moli R; Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, 95122, Catania, Italy., Belfiore A; Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, 95122, Catania, Italy., Frasca F; Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, 95122, Catania, Italy. f.frasca@unict.it.
المصدر: Journal of endocrinological investigation [J Endocrinol Invest] 2024 Jul; Vol. 47 (7), pp. 1691-1700. Date of Electronic Publication: 2024 Mar 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : Berlin : Springer
Original Publication: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis.
مواضيع طبية MeSH: Insulin-Like Growth Factor I*/analysis , Insulin-Like Growth Factor I*/metabolism , Spinal Fractures*/blood , Spinal Fractures*/epidemiology , Spinal Fractures*/etiology , Spinal Fractures*/diagnosis , beta-Thalassemia*/blood , beta-Thalassemia*/complications , beta-Thalassemia*/diagnosis , Biomarkers*/blood, Humans ; Male ; Adult ; Retrospective Studies ; Osteoporosis/blood ; Osteoporosis/etiology ; Osteoporosis/diagnosis ; Middle Aged ; Prognosis
مستخلص: Purpose: Patients with beta-thalassemia major (BTM) often develop several endocrine disorders due to chronic iron overload. They are also prone to osteoporosis and vertebral fractures. Plasmatic insulin-like growth factor-1 (IGF-1) levels are often low in subjects with BTM, which origin is multifactorial. The aim of this study was to evaluate a possible relationship between serum IGF-1 levels and the presence of osteoporosis and/or vertebral fractures.
Methods: We retrospectively evaluated the occurrence of vertebral fractures in 30 adult male patients affected by BTM (mean age 43.3 ± 7.9 years) with low serum IGF-1 (median value 52.4 ng/ml, 38.5-83.4). Only 6 of them (20.0%) were diagnosed with GH deficiency (GHD) after GHRH/arginine stimulation test, while 23 (76.7%) had osteoporosis and 12 (40.0%) had known vertebral fractures. All patients except one also showed at least one endocrine disorder.
Results: Serum IGF-1 was significantly lower in BTM patients with vertebral fractures compared to patients without vertebral fractures (U = 41.0, p = 0.005) while it was not significantly different between patients with low bone mass compared to patients without low bone mass. The diagnosis of GHD was significantly associated with lower serum IGF-1 (p = 0.001) and vertebral fractures (p = 0.002) but not with low bone mass. After ROC analysis, we found that very low IGF-1 (≤ 50.0 ng/dl) was associated with vertebral fractures (sensitivity 83.3%, specificity 75.0%) and was also predictive of GHD (sensitivity 75.0%, specificity 100.0%).
Conclusion: Our study shows that, in male patients with BTM, serum IGF-1 ≤ 50.0 ng/dl is a marker of vertebral fractures and it is predictive of a diagnosis of GHD.
(© 2024. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).)
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فهرسة مساهمة: Keywords: Beta-thalassemia; GH deficiency; Hypogonadism; IGF-1; Osteoporosis; Vertebral fractures
المشرفين على المادة: 67763-96-6 (Insulin-Like Growth Factor I)
0 (Biomarkers)
0 (IGF1 protein, human)
تواريخ الأحداث: Date Created: 20240325 Date Completed: 20240624 Latest Revision: 20240802
رمز التحديث: 20240803
DOI: 10.1007/s40618-023-02270-6
PMID: 38526837
قاعدة البيانات: MEDLINE
الوصف
تدمد:1720-8386
DOI:10.1007/s40618-023-02270-6