دورية أكاديمية
أعرض في EDS

Combinatorial transcriptomic and genetic dissection of insulin/IGF-1 signaling-regulated longevity in Caenorhabditis elegans.

التفاصيل البيبلوغرافية
العنوان: Combinatorial transcriptomic and genetic dissection of insulin/IGF-1 signaling-regulated longevity in Caenorhabditis elegans.
المؤلفون: Ham S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Kim SS; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Park S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Kwon HC; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Ha SG; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Bae Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Lee GY; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Lee SV; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
المصدر: Aging cell [Aging Cell] 2024 Jul; Vol. 23 (7), pp. e14151. Date of Electronic Publication: 2024 Mar 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK : Blackwell Pub., c2002-
مواضيع طبية MeSH: Caenorhabditis elegans*/genetics , Caenorhabditis elegans*/metabolism , Longevity* , Signal Transduction*/genetics , Transcriptome*/genetics, Animals ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Insulin/metabolism ; Insulin-Like Growth Factor I/metabolism ; Mutation ; Receptor, Insulin/genetics ; Receptor, Insulin/metabolism
مستخلص: Classical genetic analysis is invaluable for understanding the genetic interactions underlying specific phenotypes, but requires laborious and subjective experiments to characterize polygenic and quantitative traits. Contrarily, transcriptomic analysis enables the simultaneous and objective identification of multiple genes whose expression changes are associated with specific phenotypes. Here, we conducted transcriptomic analysis of genes crucial for longevity using datasets with daf-2/insulin/IGF-1 receptor mutant Caenorhabditis elegans. Our analysis unraveled multiple epistatic relationships at the transcriptomic level, in addition to verifying genetically established interactions. Our combinatorial analysis also revealed transcriptomic changes associated with longevity conferred by daf-2 mutations. In particular, we demonstrated that the extent of lifespan changes caused by various mutant alleles of the longevity transcription factor daf-16/FOXO matched their effects on transcriptomic changes in daf-2 mutants. We identified specific aging-regulating signaling pathways and subsets of structural and functional RNA elements altered by different genes in daf-2 mutants. Lastly, we elucidated the functional cooperation between several longevity regulators, based on the combination of transcriptomic and molecular genetic analysis. These data suggest that different biological processes coordinately exert their effects on longevity in biological networks. Together our work demonstrates the utility of transcriptomic dissection analysis for identifying important genetic interactions for physiological processes, including aging and longevity.
(© 2024 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: NRF-2019R1A3B2067745 National Research Foundation of Korea
فهرسة مساهمة: Keywords: Caenorhabditis elegans; daf‐2; insulin/IGF‐1 signaling; longevity; transcriptome
المشرفين على المادة: 0 (Caenorhabditis elegans Proteins)
EC 2.7.10.1 (DAF-2 protein, C elegans)
0 (Insulin)
67763-96-6 (Insulin-Like Growth Factor I)
EC 2.7.10.1 (Receptor, Insulin)
تواريخ الأحداث: Date Created: 20240326 Date Completed: 20240720 Latest Revision: 20240806
رمز التحديث: 20240806
مُعرف محوري في PubMed: PMC11258480
DOI: 10.1111/acel.14151
PMID: 38529797
قاعدة البيانات: MEDLINE
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