دورية أكاديمية
أعرض في EDS

NLC-Based Sunscreen Formulations with Optimized Proportion of Encapsulated and Free Filters Exhibit Enhanced UVA and UVB Photoprotection.

التفاصيل البيبلوغرافية
العنوان: NLC-Based Sunscreen Formulations with Optimized Proportion of Encapsulated and Free Filters Exhibit Enhanced UVA and UVB Photoprotection.
المؤلفون: de Araújo MM; Aché Laboratórios Farmacêuticos, Rod. Pres. Dutra-Porto da Igreja, Guarulhos 07034-904, SP, Brazil., Schneid AC; Aché Laboratórios Farmacêuticos, Rod. Pres. Dutra-Porto da Igreja, Guarulhos 07034-904, SP, Brazil., Oliveira MS; Aché Laboratórios Farmacêuticos, Rod. Pres. Dutra-Porto da Igreja, Guarulhos 07034-904, SP, Brazil., Mussi SV; Aché Laboratórios Farmacêuticos, Rod. Pres. Dutra-Porto da Igreja, Guarulhos 07034-904, SP, Brazil., de Freitas MN; Aché Laboratórios Farmacêuticos, Rod. Pres. Dutra-Porto da Igreja, Guarulhos 07034-904, SP, Brazil., Carvalho FC; Ferring Pharmaceuticals, Av. Engenheiro Luis Carlos Berrini-Cidade Monções, São Paulo 04571-010, SP, Brazil., Bernes Junior EA; Aché Laboratórios Farmacêuticos, Rod. Pres. Dutra-Porto da Igreja, Guarulhos 07034-904, SP, Brazil., Faro R; Ferring Pharmaceuticals, Av. Engenheiro Luis Carlos Berrini-Cidade Monções, São Paulo 04571-010, SP, Brazil., Azevedo H; Aché Laboratórios Farmacêuticos, Rod. Pres. Dutra-Porto da Igreja, Guarulhos 07034-904, SP, Brazil.
المصدر: Pharmaceutics [Pharmaceutics] 2024 Mar 20; Vol. 16 (3). Date of Electronic Publication: 2024 Mar 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: The topical use of sunscreens is recommended for avoiding the damaging effects of UV radiation. However, improvements are still needed in the existing products to enhance their photoprotection effectiveness and safety. This involves minimizing the use of chemical UV filters while providing enhanced and prolonged photoprotection. This work investigated novel sunscreen formulations and their UV protection effects by encapsulating Uvinul ® A, Tinosorb ® S, and Uvinul ® T150 into nanostructured lipid carriers (NLCs) based on bacuri butter and raspberry seed oil. First, the impact of critical formulation and process parameters on NLCs' particle size was evaluated using a 2 2 Face Centered Central Composite Design. Then, formulations were evaluated in terms of critical quality factors, in vitro skin permeation, and in vitro and in vivo photoprotection activities. The developed NLCs-containing formulations exhibited appropriate size (122-135 nm), PdI (<0.3), encapsulation efficiency (>90%), and drug content (>80%), which were preserved for at least 90 days under different stability conditions. Moreover, these NLCs-based formulations had equivalent skin permeation to emulsion-based controls, and the addition of NLCs into sunscreen cream bases in the optimum proportion of 20% ( w / w ) resulted in enhanced UVA and UVB photoprotection levels, despite a 10% reduction in the total filters content. Altogether, these results describe the application of nanoencapsulated organic UV filters in innovative sunscreen formulations to achieve superior photoprotection and cosmeceutical properties.
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معلومات مُعتمدة: x Ferring Pharmaceuticals (United States); x Aché (Brazil)
فهرسة مساهمة: Keywords: in vitro photoprotection; in vivo photoprotection; industrial research; nanostructured lipid carrier; skin penetration; sunscreen
تواريخ الأحداث: Date Created: 20240328 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC10974804
DOI: 10.3390/pharmaceutics16030427
PMID: 38543321
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics16030427