دورية أكاديمية
Novel Universal Recombinant Rotavirus A Vaccine Candidate: Evaluation of Immunological Properties.
| العنوان: | Novel Universal Recombinant Rotavirus A Vaccine Candidate: Evaluation of Immunological Properties. |
|---|---|
| المؤلفون: | Granovskiy DL; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Khudainazarova NS; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Evtushenko EA; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Ryabchevskaya EM; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Kondakova OA; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Arkhipenko MV; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Kovrizhko MV; Rostov Research Institute of Microbiology and Parasitology, 344010 Rostov-On-Don, Russia., Kolpakova EP; Rostov Research Institute of Microbiology and Parasitology, 344010 Rostov-On-Don, Russia., Tverdokhlebova TI; Rostov Research Institute of Microbiology and Parasitology, 344010 Rostov-On-Don, Russia., Nikitin NA; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Karpova OV; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia. |
| المصدر: | Viruses [Viruses] 2024 Mar 12; Vol. 16 (3). Date of Electronic Publication: 2024 Mar 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مواضيع طبية MeSH: | Rotavirus*/genetics , Rotavirus Infections* , Gastroenteritis*/prevention & control , Rotavirus Vaccines*/genetics, Animals ; Mice ; Child ; Humans ; Child, Preschool ; Prospective Studies ; Antibodies, Viral ; Vaccines, Synthetic/genetics |
| مستخلص: | Rotavirus infection is a leading cause of severe dehydrating gastroenteritis in children under 5 years of age. Although rotavirus-associated mortality has decreased considerably because of the introduction of the worldwide rotavirus vaccination, the global burden of rotavirus-associated gastroenteritis remains high. Current vaccines have a number of disadvantages; therefore, there is a need for innovative approaches in rotavirus vaccine development. In the current study, a universal recombinant rotavirus antigen (URRA) for a novel recombinant vaccine candidate against rotavirus A was obtained and characterised. This antigen included sequences of the VP8* subunit of rotavirus spike protein VP4. For the URRA, for the first time, two approaches were implemented simultaneously-the application of a highly conserved neutralising epitope and the use of the consensus of the extended protein's fragment. The recognition of URRA by antisera to patient-derived field rotavirus isolates was proven. Plant virus-based spherical particles (SPs), a novel, effective and safe adjuvant, considerably enhanced the immunogenicity of the URRA in a mouse model. Given these facts, a URRA + SPs vaccine candidate is regarded as a prospective basis for a universal vaccine against rotavirus. |
| References: | Iran J Public Health. 2012;41(5):73-84. (PMID: 23113180) Vaccine. 2019 Jul 9;37(30):4103-4110. (PMID: 31201052) Front Microbiol. 2024 Jan 05;14:1297269. (PMID: 38249482) J Gen Virol. 2007 Feb;88(Pt 2):604-612. (PMID: 17251579) J Infect Dis. 2012 Oct;206(8):1275-9. (PMID: 22872730) N Engl J Med. 2014 Feb 6;370(6):513-9. (PMID: 24422678) Vaccine. 2018 Apr 12;36(16):2086-2092. (PMID: 29555220) Vaccines (Basel). 2014 Jul 02;2(3):515-36. (PMID: 26344743) Infect Genet Evol. 2014 Dec;28:446-61. (PMID: 25224179) Lancet Glob Health. 2020 Sep;8(9):e1195-e1202. (PMID: 32827481) JAMA Pediatr. 2018 Oct 1;172(10):958-965. (PMID: 30105384) Biochim Biophys Acta. 2006 Dec;1760(12):1884-93. (PMID: 16978788) Vaccine. 2015 May 21;33(22):2606-13. (PMID: 25882173) ACS Nano. 2020 Mar 24;14(3):2994-3003. (PMID: 32133838) Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7774-9. (PMID: 10393897) Pediatr Infect Dis J. 2015 Mar;34(3):326-8. (PMID: 25742082) Euro Surveill. 2019 Feb;24(6):. (PMID: 30755297) Clin Exp Vaccine Res. 2021 Sep;10(3):203-210. (PMID: 34703802) Viruses. 2021 Sep 23;13(10):. (PMID: 34696335) Front Microbiol. 2022 Feb 28;13:845316. (PMID: 35295298) Pathogens. 2020 Aug 19;9(9):. (PMID: 32824938) Virology. 2014 Jan 20;449:163-73. (PMID: 24418549) Pediatr Infect Dis J. 2021 Dec 1;40(12):1135-1143. (PMID: 34870393) Clin Exp Vaccine Res. 2021 May;10(2):123-131. (PMID: 34222124) J Infect Dis. 2023 Sep 21;:. (PMID: 37738554) Lancet Infect Dis. 2020 Jul;20(7):851-863. (PMID: 32251641) PLoS One. 2012;7(2):e31925. (PMID: 22363771) Pediatrics. 2010 Feb;125(2):e438-41. (PMID: 20100758) Biochem J. 2003 Nov 15;376(Pt 1):269-75. (PMID: 12901721) Pediatr Infect Dis J. 2015 Jan;34(1):114-5. (PMID: 25741807) Rev Argent Microbiol. 2021 Jul-Sep;53(3):216-219. (PMID: 33526290) Vaccine. 2016 Jul 12;34(32):3684-9. (PMID: 27286641) Vaccine. 2022 Aug 19;40(35):5114-5125. (PMID: 35871871) Vaccine. 2012 Sep 21;30(43):6121-6. (PMID: 22885016) Infect Genet Evol. 2012 Aug;12(6):1282-94. (PMID: 22487061) Lancet Infect Dis. 2017 Aug;17(8):843-853. (PMID: 28483414) Vaccine. 2019 Nov 28;37(50):7328-7335. (PMID: 28396207) Virol J. 2011 Mar 08;8:109. (PMID: 21385425) Regul Toxicol Pharmacol. 2018 Aug;97:127-133. (PMID: 29932979) Clin Infect Dis. 2013 Nov;57(10):1427-34. (PMID: 23964090) IJID Reg. 2022 Jul 14;4:146-151. (PMID: 35923644) Antiviral Res. 2017 Aug;144:27-33. (PMID: 28511994) Sci Transl Med. 2017 Jun 21;9(395):. (PMID: 28637924) Vaccines (Basel). 2022 Feb 23;10(3):. (PMID: 35334978) Chem Rev. 2020 Mar 25;120(6):3210-3229. (PMID: 31804810) Front Microbiol. 2022 Sep 09;13:1003969. (PMID: 36160184) N Engl J Med. 2011 Jun 16;364(24):2283-92. (PMID: 21675888) Arch Virol. 2008;153(8):1621-9. (PMID: 18604469) |
| معلومات مُعتمدة: | 23-74-01008 Russian Science Foundation |
| فهرسة مساهمة: | Keywords: plant virus adjuvants; recombinant antigen; recombinant vaccine; rotavirus; rotavirus vaccine; spherical particles; structurally modified plant viruses; tobacco mosaic virus |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Vaccines, Synthetic) 0 (Rotavirus Vaccines) |
| تواريخ الأحداث: | Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240522 |
| رمز التحديث: | 20240522 |
| مُعرف محوري في PubMed: | PMC10976063 |
| DOI: | 10.3390/v16030438 |
| PMID: | 38543803 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!