دورية أكاديمية
Novel Universal Recombinant Rotavirus A Vaccine Candidate: Evaluation of Immunological Properties.
العنوان: | Novel Universal Recombinant Rotavirus A Vaccine Candidate: Evaluation of Immunological Properties. |
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المؤلفون: | Granovskiy DL; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Khudainazarova NS; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Evtushenko EA; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Ryabchevskaya EM; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Kondakova OA; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Arkhipenko MV; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Kovrizhko MV; Rostov Research Institute of Microbiology and Parasitology, 344010 Rostov-On-Don, Russia., Kolpakova EP; Rostov Research Institute of Microbiology and Parasitology, 344010 Rostov-On-Don, Russia., Tverdokhlebova TI; Rostov Research Institute of Microbiology and Parasitology, 344010 Rostov-On-Don, Russia., Nikitin NA; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Karpova OV; Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia. |
المصدر: | Viruses [Viruses] 2024 Mar 12; Vol. 16 (3). Date of Electronic Publication: 2024 Mar 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مواضيع طبية MeSH: | Rotavirus*/genetics , Rotavirus Infections* , Gastroenteritis*/prevention & control , Rotavirus Vaccines*/genetics, Animals ; Mice ; Child ; Humans ; Child, Preschool ; Prospective Studies ; Antibodies, Viral ; Vaccines, Synthetic/genetics |
مستخلص: | Rotavirus infection is a leading cause of severe dehydrating gastroenteritis in children under 5 years of age. Although rotavirus-associated mortality has decreased considerably because of the introduction of the worldwide rotavirus vaccination, the global burden of rotavirus-associated gastroenteritis remains high. Current vaccines have a number of disadvantages; therefore, there is a need for innovative approaches in rotavirus vaccine development. In the current study, a universal recombinant rotavirus antigen (URRA) for a novel recombinant vaccine candidate against rotavirus A was obtained and characterised. This antigen included sequences of the VP8* subunit of rotavirus spike protein VP4. For the URRA, for the first time, two approaches were implemented simultaneously-the application of a highly conserved neutralising epitope and the use of the consensus of the extended protein's fragment. The recognition of URRA by antisera to patient-derived field rotavirus isolates was proven. Plant virus-based spherical particles (SPs), a novel, effective and safe adjuvant, considerably enhanced the immunogenicity of the URRA in a mouse model. Given these facts, a URRA + SPs vaccine candidate is regarded as a prospective basis for a universal vaccine against rotavirus. |
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معلومات مُعتمدة: | 23-74-01008 Russian Science Foundation |
فهرسة مساهمة: | Keywords: plant virus adjuvants; recombinant antigen; recombinant vaccine; rotavirus; rotavirus vaccine; spherical particles; structurally modified plant viruses; tobacco mosaic virus |
المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Vaccines, Synthetic) 0 (Rotavirus Vaccines) |
تواريخ الأحداث: | Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240522 |
رمز التحديث: | 20240522 |
مُعرف محوري في PubMed: | PMC10976063 |
DOI: | 10.3390/v16030438 |
PMID: | 38543803 |
قاعدة البيانات: | MEDLINE |
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