دورية أكاديمية
An updated systematic review of neuroprotective agents in the treatment of spinal cord injury.
| العنوان: | An updated systematic review of neuroprotective agents in the treatment of spinal cord injury. |
|---|---|
| المؤلفون: | Serag I; Faculty of Medicine, Mansoura University, Mansoura, Egypt., Abouzid M; Department of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3 St, 60-806, Poznan, Poland. mmahmoud@ump.edu.pl.; Doctoral School, Poznan University of Medical Sciences, 60-812, Poznan, Poland. mmahmoud@ump.edu.pl., Elmoghazy A; Faculty of Medicine, Mansoura University, Mansoura, Egypt., Sarhan K; Faculty of Medicine, Mansoura University, Mansoura, Egypt., Alsaad SA; Faculty of Applied Medical Sciences, Jerash University, Jerash, Jordan., Mohamed RG; Mansoura Manchester Program for Medical Education, Faculty of Medicine, Mansoura University, Mansoura, Egypt. |
| المصدر: | Neurosurgical review [Neurosurg Rev] 2024 Mar 28; Vol. 47 (1), pp. 132. Date of Electronic Publication: 2024 Mar 28. |
| نوع المنشور: | Systematic Review; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Berlin Heidelberg Country of Publication: Germany NLM ID: 7908181 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-2320 (Electronic) Linking ISSN: 03445607 NLM ISO Abbreviation: Neurosurg Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Berlin Heidelberg Original Publication: Berlin : Walter De Gruyter |
| مواضيع طبية MeSH: | Neuroprotective Agents*/therapeutic use , Spinal Cord Injuries*/drug therapy , Erythropoietin*/therapeutic use, Humans ; Riluzole/therapeutic use ; Blood Alcohol Content ; Progesterone/therapeutic use ; Methylprednisolone/therapeutic use ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Vitamin D/therapeutic use |
| مستخلص: | This systematic review aims to summarize the findings from all clinical randomized trials assessing the efficacy of potential neuroprotective agents in influencing the outcomes of acute spinal cord injuries (SCI). Following the PRISMA guidelines, we conducted comprehensive searches in four electronic databases (PubMed, Scopus, Cochrane Library, and Web of Science) up to September 5th, 2023. Our analysis included a total of 30 studies. We examined the effects of 15 substances/drugs: methylprednisolone, tirilazad mesylate, erythropoietin, nimodipine, naloxone, Sygen, Rho protein antagonist, granulocyte colony-stimulating factor, autologous macrophages, autologous bone marrow cells, vitamin D, progesterone, riluzole, minocycline, and blood alcohol concentration. Notable improvements in neurological outcomes were observed with progesterone plus vitamin D and granulocyte colony-stimulating factor. In contrast, results for methylprednisolone, erythropoietin, Sygen, Rho Protein, and Riluzole were inconclusive, primarily due to insufficient sample size or outdated evidence. No significant differences were found in the remaining evaluated drugs. Progesterone plus vitamin D, granulocyte colony-stimulating factor, methylprednisolone, Sygen, Rho Protein, and Riluzole may enhance neurological outcomes in acute SCI cases. It is worth noting that different endpoints or additional subgroup analyses may potentially alter the conclusions of individual trials. Therefore, certain SCI grades may benefit more from these treatments than others, while the overall results may remain inconclusive. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Drugs; Efficacy; Neuroprotection; Outcomes; Randomized trials; Spinal cord injury |
| المشرفين على المادة: | 0 (Neuroprotective Agents) 7LJ087RS6F (Riluzole) 0 (Blood Alcohol Content) 4G7DS2Q64Y (Progesterone) X4W7ZR7023 (Methylprednisolone) 11096-26-7 (Erythropoietin) 143011-72-7 (Granulocyte Colony-Stimulating Factor) 1406-16-2 (Vitamin D) |
| تواريخ الأحداث: | Date Created: 20240328 Date Completed: 20240401 Latest Revision: 20240401 |
| رمز التحديث: | 20240401 |
| DOI: | 10.1007/s10143-024-02372-6 |
| PMID: | 38546884 |
| قاعدة البيانات: | MEDLINE |
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