دورية أكاديمية
أعرض في EDS

Physical properties and enamel remineralization potential of arginine-fluoride varnishes.

التفاصيل البيبلوغرافية
العنوان: Physical properties and enamel remineralization potential of arginine-fluoride varnishes.
المؤلفون: Bijle MN; Post-doctoral Fellow in Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong. Electronic address: info@drnadeembijle.com., Naseer TK; Intern/Research Assistant, Paediatric Dentistry, Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates., Yiu C; Clinical Professor in Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
المصدر: Journal of dentistry [J Dent] 2024 Sep; Vol. 148, pp. 104965. Date of Electronic Publication: 2024 Mar 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0354422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-176X (Electronic) Linking ISSN: 03005712 NLM ISO Abbreviation: J Dent Subsets: MEDLINE
أسماء مطبوعة: Publication: Kidlington : Elsevier
Original Publication: Bristol, Eng., Wright.
مواضيع طبية MeSH: Arginine*/therapeutic use , Arginine*/pharmacology , Dental Enamel*/drug effects , Tooth Remineralization*/methods , Fluorides, Topical*/pharmacology , Cariostatic Agents*/therapeutic use , Cariostatic Agents*/pharmacology, Viscosity ; X-Ray Microtomography ; Sodium Fluoride/therapeutic use ; Sodium Fluoride/pharmacology ; Animals ; Calcium ; Dental Caries ; Humans ; Rheology ; Materials Testing ; Saliva, Artificial/chemistry ; Cattle ; Fluorides/therapeutic use
مستخلص: Objective: The study objectives were to examine the physical properties and enamel remineralization potential of fluoride (F) varnishes incorporated with arginine (Arg).
Methods: Four commercial F varnishes: 1) Duraphat®; 2) Flúor Protector®, 3) Fluor Protector S®, and 4) Fluorimax™ were supplemented with 2% w/v. Arg. The control/experimental varnishes underwent rheometric analysis to assess varnish density (δ), velocity (ν), and associated viscosity, both quantitatively (ν/δ) and qualitatively based on determined mass, volume, distance flow, and time under experimentation. The varnish wet/dry weights (at 2 h) were also analysed. Further, sound enamel specimens (T0) with artificial incipient caries-like lesions (T1) were treated with control/experimental varnishes and subjected to remineralization assay with artificial saliva for 6 h. Thereafter (T2), the specimens were characterized to estimate precipitated Ca and net enamel F uptake. Additionally, mineral density (MD) was assessed using micro-CT at T0, T1, and T2 to derive mineral gain (MG) and % remineralization for the treatment groups.
Results: When Arg is incorporated, the physical properties of the F-containing varnishes undergo a significant transformation, resulting in higher density, varnish weight, dry varnish weight, and viscosity compared to their respective control varnishes (p < 0.05). Incorporating Arg-in Duraphat®, Fluor Protector S®, and Fluorimax™ significantly improved both enamel Ca precipitation and F uptake compared to the respective controls (p < 0.05). Additionally, the enamel F uptake was significantly higher with all the tested varnishes when enriched with Arg (p < 0.05). The combined data for MD, MG, and % remineralization suggests that the remineralization potential of F-varnishes significantly increased when enriched with Arg (p < 0.05).
Conclusion: Incorporating Arg in inorganic F varnishes improves their physical properties and enhances the enamel remineralization potential of the varnishes.
Clinical Significance: This study highlights the possibility of incorporating Arg in distinct F-source varnishes. The synergism between active components (Arg-F) aids in enhanced remineralization and superior varnish physical properties, demonstrating a promising approach for high caries-risk patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Arginine; Caries; Fluoride; Prevention; Varnishes
المشرفين على المادة: 94ZLA3W45F (Arginine)
0 (Fluorides, Topical)
0 (Cariostatic Agents)
8ZYQ1474W7 (Sodium Fluoride)
SY7Q814VUP (Calcium)
0 (Saliva, Artificial)
Q80VPU408O (Fluorides)
تواريخ الأحداث: Date Created: 20240328 Date Completed: 20240812 Latest Revision: 20240821
رمز التحديث: 20240821
DOI: 10.1016/j.jdent.2024.104965
PMID: 38548164
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-176X
DOI:10.1016/j.jdent.2024.104965