دورية أكاديمية
Mitochondrial extracellular vesicles, autoimmunity and myocarditis.
العنوان: | Mitochondrial extracellular vesicles, autoimmunity and myocarditis. |
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المؤلفون: | Di Florio DN; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United States.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States., Beetler DJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United States.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States., McCabe EJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States., Sin J; Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, United States., Ikezu T; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States., Fairweather D; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United States.; Department of Immunology, Mayo Clinic, Jacksonville, FL, United States.; Department of Medicine, Mayo Clinic, Jacksonville, FL, United States. |
المصدر: | Frontiers in immunology [Front Immunol] 2024 Mar 14; Vol. 15, pp. 1374796. Date of Electronic Publication: 2024 Mar 14 (Print Publication: 2024). |
نوع المنشور: | Journal Article; Review; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
مواضيع طبية MeSH: | Myocarditis* , Coxsackievirus Infections* , Autoimmune Diseases* , Extracellular Vesicles*/metabolism, Humans ; Autoimmunity ; Enterovirus B, Human ; Mitochondria/metabolism |
مستخلص: | For many decades viral infections have been suspected as 'triggers' of autoimmune disease, but mechanisms for how this could occur have been difficult to establish. Recent studies have shown that viral infections that are commonly associated with viral myocarditis and other autoimmune diseases such as coxsackievirus B3 (CVB3) and SARS-CoV-2 target mitochondria and are released from cells in mitochondrial vesicles that are able to activate the innate immune response. Studies have shown that Toll-like receptor (TLR)4 and the inflammasome pathway are activated by mitochondrial components. Autoreactivity against cardiac myosin and heart-specific immune responses that occur after infection with viruses where the heart is not the primary site of infection (e.g., CVB3, SARS-CoV-2) may occur because the heart has the highest density of mitochondria in the body. Evidence exists for autoantibodies against mitochondrial antigens in patients with myocarditis and dilated cardiomyopathy. Defects in tolerance mechanisms like autoimmune regulator gene (AIRE) may further increase the likelihood of autoreactivity against mitochondrial antigens leading to autoimmune disease. The focus of this review is to summarize current literature regarding the role of viral infection in the production of extracellular vesicles containing mitochondria and virus and the development of myocarditis. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Di Florio, Beetler, McCabe, Sin, Ikezu and Fairweather.) |
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معلومات مُعتمدة: | UL1 TR002556 United States TR NCATS NIH HHS; R21 AI154927 United States AI NIAID NIH HHS; R21 AI152318 United States AI NIAID NIH HHS; R21 AI145356 United States AI NIAID NIH HHS; R01 HL164520 United States HL NHLBI NIH HHS; TL1 TR002380 United States TR NCATS NIH HHS |
فهرسة مساهمة: | Keywords: AIRE; autoimmune disease; coxsackievirus; extracellular vesicles; mitochondria; mitochondrial-derived vesicles; myocarditis |
تواريخ الأحداث: | Date Created: 20240329 Date Completed: 20240401 Latest Revision: 20240513 |
رمز التحديث: | 20240513 |
مُعرف محوري في PubMed: | PMC10972887 |
DOI: | 10.3389/fimmu.2024.1374796 |
PMID: | 38550582 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-3224 |
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DOI: | 10.3389/fimmu.2024.1374796 |