دورية أكاديمية
Mitochondrial extracellular vesicles, autoimmunity and myocarditis.
| العنوان: | Mitochondrial extracellular vesicles, autoimmunity and myocarditis. |
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| المؤلفون: | Di Florio DN; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United States.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States., Beetler DJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United States.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States., McCabe EJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States., Sin J; Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, United States., Ikezu T; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States., Fairweather D; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United States.; Department of Immunology, Mayo Clinic, Jacksonville, FL, United States.; Department of Medicine, Mayo Clinic, Jacksonville, FL, United States. |
| المصدر: | Frontiers in immunology [Front Immunol] 2024 Mar 14; Vol. 15, pp. 1374796. Date of Electronic Publication: 2024 Mar 14 (Print Publication: 2024). |
| نوع المنشور: | Journal Article; Review; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Myocarditis* , Coxsackievirus Infections* , Autoimmune Diseases* , Extracellular Vesicles*/metabolism, Humans ; Autoimmunity ; Enterovirus B, Human ; Mitochondria/metabolism |
| مستخلص: | For many decades viral infections have been suspected as 'triggers' of autoimmune disease, but mechanisms for how this could occur have been difficult to establish. Recent studies have shown that viral infections that are commonly associated with viral myocarditis and other autoimmune diseases such as coxsackievirus B3 (CVB3) and SARS-CoV-2 target mitochondria and are released from cells in mitochondrial vesicles that are able to activate the innate immune response. Studies have shown that Toll-like receptor (TLR)4 and the inflammasome pathway are activated by mitochondrial components. Autoreactivity against cardiac myosin and heart-specific immune responses that occur after infection with viruses where the heart is not the primary site of infection (e.g., CVB3, SARS-CoV-2) may occur because the heart has the highest density of mitochondria in the body. Evidence exists for autoantibodies against mitochondrial antigens in patients with myocarditis and dilated cardiomyopathy. Defects in tolerance mechanisms like autoimmune regulator gene (AIRE) may further increase the likelihood of autoreactivity against mitochondrial antigens leading to autoimmune disease. The focus of this review is to summarize current literature regarding the role of viral infection in the production of extracellular vesicles containing mitochondria and virus and the development of myocarditis. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Di Florio, Beetler, McCabe, Sin, Ikezu and Fairweather.) |
| References: | J Exp Med. 2003 Feb 3;197(3):323-31. (PMID: 12566416) Science. 2019 Nov 15;366(6467):881-886. (PMID: 31727837) Clin Exp Immunol. 1984 Nov;58(2):283-92. (PMID: 6238732) J Extracell Vesicles. 2022 Jan;11(1):e12190. (PMID: 35041301) Curr Biol. 2008 Jan 22;18(2):102-8. (PMID: 18207745) J Cell Biol. 2009 Jul 27;186(2):255-68. (PMID: 19635843) Cell Mol Immunol. 2021 May;18(5):1122-1140. (PMID: 33795850) Sci Adv. 2021 Feb 12;7(7):. (PMID: 33579698) Am J Pathol. 1997 Jun;150(6):2061-74. (PMID: 9176398) Am J Pathol. 1991 Aug;139(2):337-54. (PMID: 1867322) Front Immunol. 2023 Nov 03;14:1304281. (PMID: 38022632) Circ Res. 2023 May 12;132(10):1302-1319. (PMID: 37167363) Front Immunol. 2021 Feb 09;11:628576. (PMID: 33633746) Science. 2010 Jan 29;327(5965):580-3. (PMID: 20110505) Infect Genet Evol. 2014 Aug;26:95-102. (PMID: 24836289) Nat Rev Immunol. 2002 Aug;2(8):569-79. (PMID: 12154376) J Clin Endocrinol Metab. 2019 Oct 1;104(10):4607-4618. (PMID: 31199456) Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):817-25. (PMID: 18433711) Expert Rev Clin Immunol. 2012 Mar;8(3):269-84. (PMID: 22390491) Nat Rev Mol Cell Biol. 2011 Jan;12(1):9-14. (PMID: 21179058) Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129400. (PMID: 31344401) Eur J Heart Fail. 2002 Aug;4(4):411-7. (PMID: 12167378) Exp Cell Res. 2016 Dec 10;349(2):255-263. (PMID: 27793649) Adv Myocardiol. 1985;6:311-27. (PMID: 2581297) Nat Immunol. 2017 Mar;18(3):263-273. (PMID: 28135252) J Extracell Vesicles. 2019 Aug 27;8(1):1635420. (PMID: 31497264) J Extracell Vesicles. 2021 Dec;10(14):e12182. (PMID: 34953156) Ann Neurol. 2017 May;81(5):703-717. (PMID: 28411393) EMBO J. 2014 Oct 1;33(19):2142-56. (PMID: 25107473) Front Cell Infect Microbiol. 2021 Jul 06;11:704494. (PMID: 34295842) Theranostics. 2018 Apr 9;8(10):2709-2721. (PMID: 29774070) Arthritis Rheum. 2012 Apr;64(4):1227-36. (PMID: 22238051) Int J Biol Sci. 2020 Jan 1;16(4):620-632. (PMID: 32025210) Nucleic Acids Res. 2021 Jan 8;49(D1):D1541-D1547. (PMID: 33174596) J Autoimmun. 2011 May;36(3-4):173-80. (PMID: 21376534) J Immunol. 2003 May 1;170(9):4731-7. (PMID: 12707353) Biomark Med. 2014;8(5):653-61. (PMID: 25123034) J Exp Med. 2015 Nov 16;212(12):1993-2002. (PMID: 26527800) J Virol. 2017 Nov 30;91(24):. (PMID: 28978702) Biochemistry (Mosc). 2020 Dec;85(12):1484-1498. (PMID: 33705288) Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6413-8. (PMID: 24733894) Nat Immunol. 2002 Apr;3(4):338-40. (PMID: 11919574) J Allergy Clin Immunol. 2007 Dec;120(6):1418-24. (PMID: 17868797) Cell Death Dis. 2018 Feb 14;9(2):242. (PMID: 29445155) Sci Rep. 2017 Oct 30;7(1):14293. (PMID: 29084979) Am J Pathol. 1964 May;44:775-97. (PMID: 14155025) Nature. 2013 Apr 18;496(7445):367-71. (PMID: 23542590) Cell Host Microbe. 2009 Oct 22;6(4):367-80. (PMID: 19837376) J Autoimmun. 2019 Aug;102:142-149. (PMID: 31103269) Immunity. 2010 Mar 26;32(3):305-15. (PMID: 20346772) J Autoimmun. 2001 May;16(3):175-86. (PMID: 11334481) Small. 2023 Dec;19(49):e2303317. (PMID: 37612820) J Clin Invest. 2011 Apr;121(4):1561-73. (PMID: 21436590) Nat Rev Immunol. 2016 Apr;16(4):247-58. (PMID: 26972725) Stem Cell Reports. 2017 May 9;8(5):1214-1225. (PMID: 28494937) Matrix Biol. 2012 May;31(4):229-33. (PMID: 22406378) Curr Rheumatol Rep. 2022 Apr;24(4):88-95. (PMID: 35290598) Mediators Inflamm. 2022 Mar 25;2022:9946439. (PMID: 35369030) Mol Cell Neurosci. 2018 Jun;89:71-79. (PMID: 29678518) Arthritis Res Ther. 2015 Apr 16;17:103. (PMID: 25886192) Mol Aspects Med. 2023 Jun;91:101138. (PMID: 36050142) J Mol Cell Cardiol. 1985 Jun;17(6):603-17. (PMID: 2991541) J Clin Invest. 2016 Apr 1;126(4):1181-9. (PMID: 27035809) PLoS Pathog. 2022 Aug 31;18(8):e1010350. (PMID: 36044516) Biochem Biophys Res Commun. 2017 Mar 11;484(3):550-556. (PMID: 28131843) JCI Insight. 2016 Jun 16;1(9):. (PMID: 27366791) Postgrad Med J. 1978 Jul;54(633):500-4. (PMID: 704517) Mol Immunol. 2018 Nov;103:115-124. (PMID: 30248487) Proc Natl Acad Sci U S A. 2003 May 27;100(11):6670-5. (PMID: 12743365) PLoS Pathog. 2014 Apr 10;10(4):e1004045. (PMID: 24722773) Front Cardiovasc Med. 2023 Mar 02;10:1129348. (PMID: 36937911) Biology (Basel). 2021 Apr 23;10(5):. (PMID: 33922446) J Am Coll Cardiol. 2021 Mar 2;77(8):1073-1088. (PMID: 33632482) J Extracell Vesicles. 2018 Nov 23;7(1):1535750. (PMID: 30637094) Cell. 2015 Feb 12;160(4):619-630. (PMID: 25679758) Curr Biol. 2012 Jan 24;22(2):135-41. (PMID: 22226745) Front Immunol. 2018 Mar 01;9:322. (PMID: 29545790) Signal Transduct Target Ther. 2021 Feb 16;6(1):65. (PMID: 33589598) J Immunol. 2006 Mar 15;176(6):3516-24. (PMID: 16517720) Front Immunol. 2018 Feb 26;9:350. (PMID: 29535726) J Autoimmun. 2014 Feb-Mar;48-49:84-9. (PMID: 24485157) Int J Mol Sci. 2023 May 16;24(10):. (PMID: 37240194) Cell Metab. 2019 Feb 5;29(2):348-361.e6. (PMID: 30318337) Arthritis Res Ther. 2009;11(5):R156. (PMID: 19832990) Nat Rev Rheumatol. 2022 Nov;18(11):621-640. (PMID: 36175664) J Exp Med. 1996 Mar 1;183(3):1161-72. (PMID: 8642258) Sci Transl Med. 2015 Nov 25;7(315):315ra190. (PMID: 26606969) Nat Rev Dis Primers. 2019 May 9;5(1):32. (PMID: 31073128) Eur J Biochem. 1984 Sep 17;143(3):599-605. (PMID: 6090134) Mediators Inflamm. 2019 Apr 1;2019:4050796. (PMID: 31065234) EMBO Mol Med. 2013 Feb;5(2):235-49. (PMID: 23165896) J Immunol. 1994 Jan 1;152(1):343-50. (PMID: 8254202) Viruses. 2015 Sep 17;7(9):5066-83. (PMID: 26393640) Front Immunol. 2022 Apr 20;13:822995. (PMID: 35514984) J Virol. 2007 Nov;81(22):12543-53. (PMID: 17804493) Nat Rev Cardiol. 2021 Mar;18(3):169-193. (PMID: 33046850) Mol Aspects Med. 2023 Jun;91:101155. (PMID: 36456416) PLoS One. 2012;7(12):e52830. (PMID: 23300790) Clin Exp Immunol. 2015 Jun;180(3):442-51. (PMID: 25639560) JACC CardioOncol. 2021 Jul 27;3(3):428-440. (PMID: 34604804) Curr Rheumatol Rep. 2000 Jun;2(3):201-11. (PMID: 11123060) |
| معلومات مُعتمدة: | UL1 TR002556 United States TR NCATS NIH HHS; R21 AI154927 United States AI NIAID NIH HHS; R21 AI152318 United States AI NIAID NIH HHS; R21 AI145356 United States AI NIAID NIH HHS; R01 HL164520 United States HL NHLBI NIH HHS; TL1 TR002380 United States TR NCATS NIH HHS |
| فهرسة مساهمة: | Keywords: AIRE; autoimmune disease; coxsackievirus; extracellular vesicles; mitochondria; mitochondrial-derived vesicles; myocarditis |
| تواريخ الأحداث: | Date Created: 20240329 Date Completed: 20240401 Latest Revision: 20240513 |
| رمز التحديث: | 20240513 |
| مُعرف محوري في PubMed: | PMC10972887 |
| DOI: | 10.3389/fimmu.2024.1374796 |
| PMID: | 38550582 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2024.1374796 |