دورية أكاديمية
Curcumin alleviates cecal oxidative injury in diquat-induced broilers by regulating the Nrf2/ARE pathway and microflora.
| العنوان: | Curcumin alleviates cecal oxidative injury in diquat-induced broilers by regulating the Nrf2/ARE pathway and microflora. |
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| المؤلفون: | Wu F; College of Animal Science and Technology, Hebei Agricultural University, Baoding, 071000 China; College of Food Science and Technology, Hebei Agricultural University, Baoding, 071000 China., Zhao M; College of Animal Science and Technology, Hebei Agricultural University, Baoding, 071000 China., Tang Z; Hebei Research Institute of Microbiology Co., LTD, Baoding, 071000 China., Wang F; College of Animal Science and Technology, Hebei Agricultural University, Baoding, 071000 China., Han S; College of Animal Science and Technology, Hebei Agricultural University, Baoding, 071000 China., Liu S; College of Animal Science and Technology, Hebei Agricultural University, Baoding, 071000 China., Chen B; College of Animal Science and Technology, Hebei Agricultural University, Baoding, 071000 China. Electronic address: chenbaojiang@vip.sina.com. |
| المصدر: | Poultry science [Poult Sci] 2024 May; Vol. 103 (5), pp. 103651. Date of Electronic Publication: 2024 Mar 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Cambridge, UK] : Elsevier Original Publication: Champaign Il : Poultry Science Association |
| مواضيع طبية MeSH: | Chickens* , Oxidative Stress*/drug effects , Curcumin*/pharmacology , Curcumin*/administration & dosage , Cecum*/drug effects , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Gastrointestinal Microbiome*/drug effects , Diquat*, Animals ; Poultry Diseases/chemically induced ; Poultry Diseases/drug therapy ; Random Allocation ; Male ; Avian Proteins/metabolism ; Avian Proteins/genetics ; Diet/veterinary ; Dietary Supplements/analysis |
| مستخلص: | This study evaluated the alleviative effect of curcumin (CUR) on the diquat (DQ)-induced cecal injury in broilers. A total of 320 one-day-old Cobb broilers were selected and randomly divided into 4 treatments, namely control, DQ, CUR 100, and CUR150 groups. The control and DQ groups were fed a basal diet, while the CUR 100 and CUR150 groups were fed the basal diet supplemented with 100 and 150 mg/kg CUR, respectively. Each group had 8 replicates, with 10 broilers per replicate. On day 21 of the experiment, 1 broiler was selected from each replicate and intraperitoneally injected 20 mg/kg body weight of DQ for DQ, CUR 100, and CUR 150 groups. Broilers in control group received equivalent volume of saline. Broilers were euthanized 48h postinjection for tissue sampling. The results showed that DQ injection could cause oxidative stress and inflammatory reactions in the cecum, affecting the fatty acid production and flora structure, thus leading to cecum damage. Compared with the DQ group, the activity of superoxide dismutase, the level of interleukin 10, acetic acid, and total volatile fatty, and the abundance of nuclear factor E2-related factor 2, copper and zinc superoxide dismutase and catalase mRNA in the cecal mucosa of broilers in the CUR group increased significantly (P < 0.05). However, the levels of malondialdehyd, reactive oxygen species, tumor necrosis factor-alpha, and the expression of cysteine-aspartic acid protease-3 and tumor necrosis factor-alpha decreased significantly (P < 0.05) in the CUR group. In addition, CUR treatment alleviated the damage to the cecum and restored the flora structure, and Lactobacillus and Lactobacillaceae promoted the alleviative effect of CUR on DQ. In summary, CUR could alleviate the cecal injury caused by DQ-induced oxidative damage and inflammatory reactions by regulating the Nrf2-ARE signaling pathway and intestinal flora, thus protecting the cecum. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: broiler; cecum; curcumin; diquat; intestinal flora |
| المشرفين على المادة: | IT942ZTH98 (Curcumin) 0 (NF-E2-Related Factor 2) A9A615U4MP (Diquat) 0 (Avian Proteins) |
| تواريخ الأحداث: | Date Created: 20240329 Date Completed: 20240430 Latest Revision: 20240501 |
| رمز التحديث: | 20240501 |
| مُعرف محوري في PubMed: | PMC10995872 |
| DOI: | 10.1016/j.psj.2024.103651 |
| PMID: | 38552344 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1525-3171 |
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| DOI: | 10.1016/j.psj.2024.103651 |