دورية أكاديمية
Lateral fluid percussion injury: A rat model of experimental traumatic brain injury.
| العنوان: | Lateral fluid percussion injury: A rat model of experimental traumatic brain injury. |
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| المؤلفون: | Huerta de la Cruz S; Department of Pharmacology, University of Vermont, Burlington, VT, United States; Departamento de Farmacobiología, Cinvestav Sede Sur, Ciudad de México, México. Electronic address: saul.huerta-de-la-cruz@uvm.edu., Santiago-Castañeda C; Departamento de Farmacobiología, Cinvestav Sede Sur, Ciudad de México, México., Rodríguez-Palma EJ; Neurobiology of Pain Laboratory, Departamento de Farmacobiología, Cinvestav, Sede Sur, Mexico City, Mexico., Rocha L; Departamento de Farmacobiología, Cinvestav Sede Sur, Ciudad de México, México., Sancho M; Department of Pharmacology, University of Vermont, Burlington, VT, United States; Department of Physiology, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain. Electronic address: masanc75@ucm.es. |
| المصدر: | Methods in cell biology [Methods Cell Biol] 2024; Vol. 185, pp. 197-224. Date of Electronic Publication: 2024 Mar 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0373334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0091-679X (Print) Linking ISSN: 0091679X NLM ISO Abbreviation: Methods Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, Academic Press |
| مواضيع طبية MeSH: | Brain Injuries, Traumatic*/complications , Brain Injuries, Traumatic*/pathology , Brain Injuries*/complications , Brain Injuries*/pathology, Rats ; Humans ; Animals ; Percussion/adverse effects ; Percussion/methods ; Reproducibility of Results ; Rats, Wistar ; Disease Models, Animal |
| مستخلص: | Traumatic brain injury (TBI) represents one of the leading causes of disability and death worldwide. The annual economic impact of TBI-including direct and indirect costs-is high, particularly impacting low- and middle-income countries. Despite extensive research, a comprehensive understanding of the primary and secondary TBI pathophysiology, followed by the development of promising therapeutic approaches, remains limited. These fundamental caveats in knowledge have motivated the development of various experimental models to explore the molecular mechanisms underpinning the pathogenesis of TBI. In this context, the Lateral Fluid Percussion Injury (LFPI) model produces a brain injury that mimics most of the neurological and systemic aspects observed in human TBI. Moreover, its high reproducibility makes the LFPI model one of the most widely used rodent-based TBI models. In this chapter, we provide a detailed surgical protocol of the LFPI model used to induce TBI in adult Wistar rats. We further highlight the neuroscore test as a valuable tool for the evaluation of TBI-induced sensorimotor consequences and their severity in rats. Lastly, we briefly summarize the current knowledge on the pathological aspects and functional outcomes observed in the LFPI-induced TBI model in rodents. (Copyright © 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training and similar technologies.) |
| فهرسة مساهمة: | Keywords: Experimental animal model; Functional outcome; Lateral fluid percussion; Sensorimotor impairments; Traumatic brain injury |
| تواريخ الأحداث: | Date Created: 20240331 Date Completed: 20240402 Latest Revision: 20240402 |
| رمز التحديث: | 20240402 |
| DOI: | 10.1016/bs.mcb.2024.02.011 |
| PMID: | 38556449 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0091-679X |
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| DOI: | 10.1016/bs.mcb.2024.02.011 |