دورية أكاديمية
Genetically guided precision medicine clinical decision support tools: a systematic review.
| العنوان: | Genetically guided precision medicine clinical decision support tools: a systematic review. |
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| المؤلفون: | Johnson D; Department of Genomic Health, Geisinger Health Systems, Danville, PA 17822, United States., Del Fiol G; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, United States., Kawamoto K; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, United States., Romagnoli KM; Department of Genomic Health, Geisinger Health Systems, Danville, PA 17822, United States., Sanders N; School of Medicine, Geisinger Health Systems, Danville, PA 17822, United States., Isaacson G; Family Medicine, Penn Highlands Healthcare, DuBois, PA 16830, United States., Jenkins E; School of Medicine, Noorda College of Osteopathic Medicine, Provo, UT 84606, United States., Williams MS; Department of Genomic Health, Geisinger Health Systems, Danville, PA 17822, United States. |
| المصدر: | Journal of the American Medical Informatics Association : JAMIA [J Am Med Inform Assoc] 2024 Apr 19; Vol. 31 (5), pp. 1183-1194. |
| نوع المنشور: | Systematic Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9430800 Publication Model: Print Cited Medium: Internet ISSN: 1527-974X (Electronic) Linking ISSN: 10675027 NLM ISO Abbreviation: J Am Med Inform Assoc |
| أسماء مطبوعة: | Publication: 2015- : Oxford : Oxford University Press Original Publication: Philadelphia, PA : Hanley & Belfus, c1993- |
| مواضيع طبية MeSH: | Decision Support Systems, Clinical* , Precision Medicine*, Humans ; Electronic Health Records ; Genomics |
| مستخلص: | Objectives: Patient care using genetics presents complex challenges. Clinical decision support (CDS) tools are a potential solution because they provide patient-specific risk assessments and/or recommendations at the point of care. This systematic review evaluated the literature on CDS systems which have been implemented to support genetically guided precision medicine (GPM). Materials and Methods: A comprehensive search was conducted in MEDLINE and Embase, encompassing January 1, 2011-March 14, 2023. The review included primary English peer-reviewed research articles studying humans, focused on the use of computers to guide clinical decision-making and delivering genetically guided, patient-specific assessments, and/or recommendations to healthcare providers and/or patients. Results: The search yielded 3832 unique articles. After screening, 41 articles were identified that met the inclusion criteria. Alerts and reminders were the most common form of CDS used. About 27 systems were integrated with the electronic health record; 2 of those used standards-based approaches for genomic data transfer. Three studies used a framework to analyze the implementation strategy. Discussion: Findings include limited use of standards-based approaches for genomic data transfer, system evaluations that do not employ formal frameworks, and inconsistencies in the methodologies used to assess genetic CDS systems and their impact on patient outcomes. Conclusion: We recommend that future research on CDS system implementation for genetically GPM should focus on implementing more CDS systems, utilization of standards-based approaches, user-centered design, exploration of alternative forms of CDS interventions, and use of formal frameworks to systematically evaluate genetic CDS systems and their effects on patient care. (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Medical Informatics Association.) |
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| معلومات مُعتمدة: | R01 HG011799 United States HG NHGRI NIH HHS; R01HG011799 United States HG NHGRI NIH HHS |
| فهرسة مساهمة: | Keywords: clinical decision support systems; electronic health record; genetics; genomics; personalized medicine |
| تواريخ الأحداث: | Date Created: 20240401 Date Completed: 20240807 Latest Revision: 20240807 |
| رمز التحديث: | 20240808 |
| مُعرف محوري في PubMed: | PMC11031215 |
| DOI: | 10.1093/jamia/ocae033 |
| PMID: | 38558013 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1527-974X |
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| DOI: | 10.1093/jamia/ocae033 |