Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum.
العنوان: | Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum. |
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المؤلفون: | Venkatesh SS; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Wittemans LBL; Novo Nordisk Research Centre Oxford, Oxford, United Kingdom.; Nuffield Department of Women's and Reproductive Health, Medical Sciences Division, University of Oxford, United Kingdom., Palmer DS; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Baya NA; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Ferreira T; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom., Hill B; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Lassen FH; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Parker MJ; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom., Reibe S; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Elhakeem A; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Banasik K; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark., Jensen BA; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Juul A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; Copenhagen, Denmark.; Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark., Nielsen HS; Department of Obstetrics and Gynecology, The Fertility Clinic, Hvidovre University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Kge, Denmark., Rohde PD; Genomic Medicine, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Sorensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Westergaard D; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark., Haraldsson A; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Children's Hospital Iceland, Landspitali University Hospital, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Jonsdottir I; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland., Steingrimsdottir T; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland., Steinthorsdottir V; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Figueredo J; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Karjalainen MK; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Finland.; Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Pasanen A; Research Unit of Clinical Medicine, Medical Research Center Oulu, University of Oulu, and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland., Jacobs BM; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University London, London, EC1M 6BQ, United Kingdom., Hubers N; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Institute, Amsterdam, The Netherlands., Lippincott M; Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Fraser A; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Timpson NJ; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Nyegaard M; Genomic Medicine, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Stefansson K; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Magi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Laivuori H; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics and Gynecology, Tampere University Hospital, Finland.; Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Finland., van Heel DA; Blizard Institute, Queen Mary University London, London, E1 2AT, United Kingdom., Boomsma DI; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Institute, Amsterdam, The Netherlands., Balasubramanian R; Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Seminara SB; Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Chan YM; Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, United States of America., Laisk T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Lindgren CM; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.; Nuffield Department of Women's and Reproductive Health, Medical Sciences Division, University of Oxford, United Kingdom.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America. |
مؤلفون مشاركون: | Genes & Health Research Team, Estonian Biobank Research Team, Estonian Health Informatics Research Team, DBDS Genomic Consortium, FinnGen |
المصدر: | MedRxiv : the preprint server for health sciences [medRxiv] 2024 Mar 20. Date of Electronic Publication: 2024 Mar 20. |
نوع المنشور: | Preprint |
اللغة: | English |
بيانات الدورية: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
مستخلص: | Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 687,005 controls. We identified 21 genetic risk loci for infertility ( P ≤5E-08), of which 12 have not been reported for any reproductive condition. We found positive genetic correlations between endometriosis and all-cause female infertility ( r Competing Interests: Competing Interests Statement L.B.L.W. is currently employed by Novo Nordisk Research Centre Oxford but, while she conducted the research described in this manuscript, was only affiliated to the University of Oxford. V.S., G.T., H.H., I.J., and K.S. are employees of deCODE genetics, a subsidiary of Amgen. C.M.L. reports grants from Bayer AG and Novo Nordisk and has a partner who works at Vertex. The other authors declare no conflicts of interest. |
References: | Nat Commun. 2015 Jan 19;6:5890. (PMID: 25597830) Reproduction. 2020 Sep;160(3):R25-R39. (PMID: 32716007) Genetics. 1950 Mar;35(2):212-36. (PMID: 17247344) J Endocrinol. 2012 Jan;212(1):27-40. (PMID: 22045753) Sci Rep. 2017 Sep 8;7(1):11008. (PMID: 28887542) Int J Epidemiol. 2015 Aug;44(4):1137-47. (PMID: 24518929) Am J Psychiatry. 2021 Jul;178(7):625-634. (PMID: 33900812) Nucleic Acids Res. 2023 Jan 6;51(D1):D1038-D1045. (PMID: 36305825) Genet Epidemiol. 2016 May;40(4):304-14. (PMID: 27061298) Nucleic Acids Res. 2021 Jan 8;49(D1):D1311-D1320. (PMID: 33045747) Nat Rev Urol. 2018 Jun;15(6):369-384. (PMID: 29622783) Hum Reprod. 2024 Jan 5;39(1):240-257. (PMID: 38052102) Nature. 2023 Jan;613(7944):519-525. (PMID: 36653560) Reprod Biol Endocrinol. 2010 Oct 11;8:117. (PMID: 20937107) Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4111-6. (PMID: 21325058) F1000Res. 2018 Oct 26;7:. (PMID: 30416711) Nat Genet. 2015 Mar;47(3):284-90. (PMID: 25642633) Nat Genet. 2003 Aug;34(4):434-9. (PMID: 12858176) Endocrinology. 1977 May;100(5):1341-7. (PMID: 557406) Nat Genet. 2016 Oct;48(10):1279-83. (PMID: 27548312) Fertil Steril. 2023 Sep;120(3 Pt 1):457-466. (PMID: 36521518) Nat Med. 2024 Jan;30(1):1. (PMID: 38242978) Nat Commun. 2016 Nov 16;7:13490. (PMID: 27848971) Nat Rev Dis Primers. 2023 Sep 14;9(1):49. (PMID: 37709866) Fertil Steril. 2002 Apr;77 Suppl 4:S3-5. (PMID: 12007895) Am J Obstet Gynecol. 2017 Jan;216(1):1-9. (PMID: 28007229) Brief Bioinform. 2013 Mar;14(2):144-61. (PMID: 22908213) Diabetes. 2011 Aug;60(8):2076-85. (PMID: 21659499) Rev Bras Ginecol Obstet. 2022 Jun;44(6):614-620. (PMID: 35576969) Lancet. 2010 Aug 28;376(9742):730-8. (PMID: 20801404) Nat Genet. 2008 Sep;40(9):1068-75. (PMID: 19165921) Genomics. 1995 Feb 10;25(3):724-6. (PMID: 7759109) Front Endocrinol (Lausanne). 2022 Oct 26;13:1020827. (PMID: 36387918) Cell. 2013 Feb 14;152(4):703-13. (PMID: 23415221) Nat Hum Behav. 2021 Dec;5(12):1717-1730. (PMID: 34211149) Hum Reprod. 1999 Sep;14 Suppl 1:108-19. (PMID: 10573028) Nat Rev Endocrinol. 2021 Jan;17(1):47-66. (PMID: 33173188) Hum Reprod. 2022 May 3;37(5):1069-1082. (PMID: 35274129) Pharmacogenomics. 2003 Mar;4(2):209-15. (PMID: 12605555) Bioinformatics. 2020 Jun 1;36(11):3439-3446. (PMID: 32196066) Cold Spring Harb Symp Quant Biol. 1955;20:1-15. (PMID: 13433550) Genome Biol. 2016 Jun 06;17(1):122. (PMID: 27268795) Nat Genet. 2015 May;47(5):435-44. (PMID: 25807286) Behav Genet. 2022 Sep;52(4-5):306-314. (PMID: 35867259) Nature. 2020 May;581(7809):434-443. (PMID: 32461654) J Assist Reprod Genet. 2015 Sep;32(9):1359-64. (PMID: 26139156) Nat Genet. 2015 Mar;47(3):291-5. (PMID: 25642630) Nat Commun. 2023 Oct 23;14(1):6713. (PMID: 37872160) PLoS Genet. 2020 Apr 20;16(4):e1008720. (PMID: 32310995) PLoS Genet. 2018 Dec 19;14(12):e1007813. (PMID: 30566500) Elife. 2018 May 30;7:. (PMID: 29846171) Mol Cell Endocrinol. 2019 Jun 1;489:119-125. (PMID: 30365983) Nature. 2010 Sep 2;467(7311):52-8. (PMID: 20811451) Int J Obes Suppl. 2019 Apr;9(1):65-72. (PMID: 31391925) Hum Reprod Update. 2016 Jan-Feb;22(1):104-15. (PMID: 26395640) Gigascience. 2015 Feb 25;4:7. (PMID: 25722852) Nat Med. 2008 Nov;14(11):1197-213. (PMID: 18989307) Genet Med. 2019 Jun;21(6):1345-1354. (PMID: 30327539) Eur J Hum Genet. 2016 Jan;24(1):135-8. (PMID: 26059840) Mol Cell Endocrinol. 2020 Dec 1;518:110974. (PMID: 32926966) Eur J Endocrinol. 2022 Feb 15;186(3):407-416. (PMID: 35049520) J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1071-e1083. (PMID: 33211867) J Psychosom Obstet Gynaecol. 2022 Dec;43(4):550-556. (PMID: 35833417) PLoS Genet. 2014 May 15;10(5):e1004383. (PMID: 24830394) Am J Hum Genet. 2019 Jan 3;104(1):65-75. (PMID: 30595370) Genome Med. 2020 Dec 2;12(1):103. (PMID: 33261662) Nat Med. 2020 Feb;26(2):252-258. (PMID: 32042192) Mol Cell Biol. 2012 Oct;32(20):4195-205. (PMID: 22890844) Nat Genet. 2016 Jun;48(6):617-623. (PMID: 27089180) Nat Genet. 2018 Sep;50(9):1335-1341. (PMID: 30104761) Elife. 2018 Sep 18;7:. (PMID: 30226466) Reprod Biomed Online. 2013 Jan;26(1):93-8. (PMID: 23177411) Hum Reprod. 2022 Jan 28;37(2):352-365. (PMID: 34791234) Ginekol Pol. 2018;89(6):304-310. (PMID: 30010178) Reprod Biol. 2004 Jul;4(2):119-29. (PMID: 15297887) J Am Stat Assoc. 2020;115(529):393-402. (PMID: 33012899) Nat Commun. 2017 Feb 27;8:14357. (PMID: 28240269) Cell. 2019 Jan 24;176(3):535-548.e24. (PMID: 30661751) BMJ Open. 2019 Jun 9;9(6):e028401. (PMID: 31182452) N Engl J Med. 2014 Mar 6;370(10):943-949. (PMID: 24597867) Cochrane Database Syst Rev. 2018 May 15;5:CD004829. (PMID: 29761478) Int J Mol Epidemiol Genet. 2013 Nov 28;4(4):193-206. (PMID: 24319535) Mol Cell Endocrinol. 2015 Feb 15;402:113-9. (PMID: 25578600) Int J Epidemiol. 2011 Jun;40(3):755-64. (PMID: 21414999) Genome Med. 2021 Jan 13;13(1):6. (PMID: 33441150) Int J Epidemiol. 2015 Apr;44(2):512-25. (PMID: 26050253) Am J Hum Genet. 2011 Jan 7;88(1):76-82. (PMID: 21167468) Endocrinology. 2021 Jul 1;162(7):. (PMID: 33963381) Nature. 2022 Apr;604(7905):310-315. (PMID: 35388217) Nat Genet. 2013 Jun;45(6):580-5. (PMID: 23715323) Reprod Biol Endocrinol. 2015 Apr 26;13:37. (PMID: 25928197) Genet Med. 2015 May;17(5):405-24. (PMID: 25741868) Chest. 2021 Dec;160(6):2051-2060. (PMID: 34284004) Int J Epidemiol. 2013 Feb;42(1):97-110. (PMID: 22507742) Nat Commun. 2019 Jul 18;10(1):3164. (PMID: 31320652) Nature. 2023 Jan;613(7944):508-518. (PMID: 36653562) Proc Soc Exp Biol Med. 1987 Dec;186(3):253-64. (PMID: 3122219) Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18026-31. (PMID: 22003128) Am J Reprod Immunol. 2011 Feb;65(2):164-72. (PMID: 20645939) Endocrinology. 2000 Jul;141(7):2392-400. (PMID: 10875239) N Engl J Med. 2017 Sep 21;377(12):1156-1167. (PMID: 28877031) Nat Genet. 2016 Dec;48(12):1462-1472. (PMID: 27798627) Nat Biotechnol. 2018 Jun;36(5):411-420. (PMID: 29608179) Infect Dis Obstet Gynecol. 2022 Nov 18;2022:3548190. (PMID: 36438172) Nat Genet. 2015 Nov;47(11):1228-35. (PMID: 26414678) Am Psychol. 2012 Feb-Mar;67(2):130-59. (PMID: 22233090) Nat Genet. 2021 Jul;53(7):1097-1103. (PMID: 34017140) Hum Reprod. 2008 Mar;23(3):462-77. (PMID: 18308833) Bioinformatics. 2010 Sep 1;26(17):2190-1. (PMID: 20616382) PLoS Genet. 2014 Jul 17;10(7):e1004503. (PMID: 25033397) Fertil Steril. 2011 Mar 1;95(3):915-21. (PMID: 21130988) Nucleic Acids Res. 2019 Jan 8;47(D1):D886-D894. (PMID: 30371827) J Reprod Immunol. 2022 Aug;152:103654. (PMID: 35728349) Hum Mol Genet. 2023 Mar 6;32(6):907-916. (PMID: 36168886) Nature. 2018 Oct;562(7726):203-209. (PMID: 30305743) Am J Epidemiol. 2017 Nov 1;186(9):1026-1034. (PMID: 28641372) Nat Commun. 2019 Oct 24;10(1):4857. (PMID: 31649266) Sci Rep. 2016 Nov 04;6:36189. (PMID: 27811963) Nature. 2016 May 11;533(7604):539-42. (PMID: 27225129) Nature. 2015 Dec 24;528(7583):499-503. (PMID: 26595274) Fertil Steril. 2021 Oct;116(4):1119-1125. (PMID: 34246467) Int J Biochem Cell Biol. 2007;39(1):31-43. (PMID: 16905353) Biol Reprod. 2018 Jul 1;99(1):101-111. (PMID: 29566165) Am J Hum Genet. 2016 Oct 6;99(4):877-885. (PMID: 27666373) Clin Exp Immunol. 2001 Mar;123(3):481-6. (PMID: 11298137) Nucleic Acids Res. 2023 Jan 6;51(D1):D1353-D1359. (PMID: 36399499) Int J Epidemiol. 2021 Jul 9;50(3):719-720e. (PMID: 33169150) Int J Epidemiol. 2020 Feb 1;49(1):20-21i. (PMID: 31504546) Nat Commun. 2021 Nov 19;12(1):6760. (PMID: 34799557) Nature. 2015 Oct 1;526(7571):68-74. (PMID: 26432245) Reprod Biol Endocrinol. 2018 Mar 9;16(1):22. (PMID: 29523133) Prenat Diagn. 2019 Jan;39(2):81-87. (PMID: 30520056) Nat Hum Behav. 2023 May;7(5):790-801. (PMID: 36864135) Am J Hum Genet. 2021 Sep 2;108(9):1792-1806. (PMID: 34411538) Endocr J. 2023 Aug 28;70(8):805-814. (PMID: 37211401) BMC Genet. 2017 Feb 14;18(1):14. (PMID: 28193154) Obstet Gynecol Clin North Am. 2015 Mar;42(1):15-25. (PMID: 25681837) Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1535-41. (PMID: 20631354) Genome Biol Evol. 2020 Feb 1;12(2):3873-3877. (PMID: 32011695) Cell. 2019 Jun 13;177(7):1888-1902.e21. (PMID: 31178118) J Biol Chem. 2010 Aug 6;285(32):24863-70. (PMID: 20529856) J Multivar Anal. 2019 Sep;173:145-164. (PMID: 32831421) Nat Genet. 2023 Mar;55(3):423-436. (PMID: 36914876) Biol Reprod. 2013 Apr 11;88(4):90. (PMID: 23446454) Dis Markers. 2013;35(6):907-13. (PMID: 24427778) PLoS Med. 2015 Mar 31;12(3):e1001779. (PMID: 25826379) Nucleic Acids Res. 2023 Jan 6;51(D1):D933-D941. (PMID: 36318249) Hum Reprod Update. 2007 Sep-Oct;13(5):433-44. (PMID: 17584821) Biol Reprod. 1986 Aug;35(1):27-36. (PMID: 3091103) Diabetes Metab Syndr. 2022 Mar;16(3):102447. (PMID: 35272174) Am J Hum Genet. 2005 Aug;77(2):280-96. (PMID: 16001362) Cell Genom. 2022 Aug 15;2(9):100168. (PMID: 36778668) Reprod Biol Endocrinol. 2005 Jun 17;3:24. (PMID: 15963226) Endocr Metab Immune Disord Drug Targets. 2010 Jun;10(2):168-74. (PMID: 20350288) Nat Genet. 2018 Apr;50(4):621-629. (PMID: 29632380) Eur J Popul. 2013 Feb;29(1):1-38. (PMID: 23440941) Nat Genet. 2021 Nov;53(11):1527-1533. (PMID: 34711957) Probiotics Antimicrob Proteins. 2019 Dec;11(4):1355-1361. (PMID: 29532416) Nucleic Acids Res. 2014 Jan;42(Database issue):D1001-6. (PMID: 24316577) J Clin Endocrinol Metab. 2019 Nov 1;104(11):5008-5023. (PMID: 31169883) Science. 2016 Nov 11;354(6313):760-764. (PMID: 27738015) Cold Spring Harb Perspect Biol. 2014 Jul 24;6(9):a008516. (PMID: 25059709) Hum Mol Genet. 2019 Jan 1;28(1):166-174. (PMID: 30239722) Int J Epidemiol. 2021 Nov 10;50(5):1639-1650. (PMID: 33619569) J Clin Invest. 2009 Aug;119(8):2184-203. (PMID: 19620783) J Clin Endocrinol Metab. 2002 Apr;87(4):1607-12. (PMID: 11932290) Nature. 2015 Feb 12;518(7538):197-206. (PMID: 25673413) Nat Commun. 2018 Sep 7;9(1):3636. (PMID: 30194396) Compr Physiol. 2018 Sep 14;8(4):1253-1290. (PMID: 30215860) Physiol Res. 2003;52(3):341-6. (PMID: 12790766) Nature. 2021 Feb;590(7845):290-299. (PMID: 33568819) PLoS One. 2015 Jun 03;10(6):e0126821. (PMID: 26039877) Nat Rev Genet. 2004 Jan;5(1):43-51. (PMID: 14708015) JAMA. 2017 Jun 13;317(22):2334. (PMID: 28609526) J Gene Med. 2024 Jan;26(1):e3583. (PMID: 37640479) Nat Biotechnol. 2015 May;33(5):495-502. (PMID: 25867923) |
معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; INV-024200 United States GATES Bill & Melinda Gates Foundation; P50 HD104224 United States HD NICHD NIH HHS |
تواريخ الأحداث: | Date Created: 20240402 Latest Revision: 20240410 |
رمز التحديث: | 20240410 |
مُعرف محوري في PubMed: | PMC10984039 |
DOI: | 10.1101/2024.03.19.24304530 |
PMID: | 38562841 |
قاعدة البيانات: | MEDLINE |
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