دورية أكاديمية
γ-Glutamyl Transferase and Long-Term Survival in the SYNTAXES Trial: Is It Just the Liver?
| العنوان: | γ-Glutamyl Transferase and Long-Term Survival in the SYNTAXES Trial: Is It Just the Liver? |
|---|---|
| المؤلفون: | Ninomiya K; Department of Cardiology University of Galway Ireland., Serruys PW; Department of Cardiology University of Galway Ireland.; National Heart and Lung Institute, Imperial College London London United Kingdom., Garg S; Department of Cardiology Royal Blackburn Hospital Blackburn United Kingdom., Kageyama S; Department of Cardiology University of Galway Ireland., Kotoku N; Department of Cardiology University of Galway Ireland., Masuda S; Department of Cardiology University of Galway Ireland., Revaiah PC; Department of Cardiology University of Galway Ireland., O'leary N; Department of Cardiology University of Galway Ireland., Kappetein AP; Department of Cardiothoracic Surgery Erasmus University Medical Centre Rotterdam the Netherlands., Mack MJ; Department of Cardiothoracic Surgery Baylor University Medical Center Dallas TX., Holmes DR; Department of Cardiovascular Diseases and Internal Medicine Mayo Clinic Rochester MN., Davierwala PM; University Department of Cardiac Surgery, Heart Centre Leipzig Leipzig Germany.; Division of Cardiovascular Surgery, Peter Munk Cardiac Centre Toronto General Hospital, University Health Network Toronto Ontario Canada.; Department of Surgery University of Toronto Canada., Mohr FW; University Department of Cardiac Surgery, Heart Centre Leipzig Leipzig Germany., Thuijs DJFM; Department of Cardiothoracic Surgery Erasmus University Medical Centre Rotterdam the Netherlands., Onuma Y; Department of Cardiology University of Galway Ireland.; Galway University Hospital Galway Ireland. |
| مؤلفون مشاركون: | SYNTAX Extended Survival (SYNTAXES) Investigators |
| المصدر: | Journal of the American Heart Association [J Am Heart Assoc] 2024 Apr 16; Vol. 13 (8), pp. e032276. Date of Electronic Publication: 2024 Apr 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell |
| مواضيع طبية MeSH: | Coronary Artery Disease*/diagnostic imaging , Coronary Artery Disease*/surgery , Percutaneous Coronary Intervention*, Male ; Humans ; Female ; gamma-Glutamyltransferase ; Treatment Outcome ; Risk Factors ; Liver |
| مستخلص: | Background: Recently, machine learning algorithms have identified preprocedural γ-glutamyl transferase (GGT) as a significant predictor of long-term mortality after coronary revascularization in the SYNTAX (Synergy Between PCI [Percutaneous Coronary Intervention] With Taxus and Cardiac Surgery) trial. The aim of the present study is to investigate the impact of preprocedural GGT on 10-year all-cause mortality in patients with complex coronary artery disease after revascularization. Methods and Results: The SYNTAX trial was a randomized trial comparing PCI with coronary artery bypass grafting in 1800 patients with complex coronary artery disease. The present report is a post hoc subanalysis of the SYNTAXES (Synergy Between PCI With Taxus and Cardiac Surgery Extended Survival) trial, an investigator-driven extended 10-year follow-up of the SYNTAX trial. The association between preprocedural GGT and 10-year all-cause mortality was investigated. The mean values of GGT for men and women were 43.5 (SD, 48.5) and 36.4 (SD, 46.1) U/L, respectively. In multivariable Cox regression models adjusted by traditional risk factors, GGT was an independent predictor for all-cause death at 10-year follow-up, and each SD increase in log-GGT was associated with a 1.24-fold risk of all cause death at 10-year follow-up (95% CI, 1.10-1.40). According to previously reported sex-related GGT thresholds, patients with higher GGT level had a 1.74-fold risk of all-cause death at 10-year follow-up (95% CI, 1.32-2.29) compared with patients with lower GGT level. Conclusions: Preprocedural GGT is an independent predictor of 10-year mortality after coronary revascularization in patients with complex coronary artery disease. In patients with elevated GGT, strong secondary prevention may be required after revascularization and must be studied prospectively. Registration: URL: https://clinicaltrials.gov/study/NCT03417050. |
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| فهرسة مساهمة: | Keywords: biological marker; long‐term clinical outcomes; machine learning; γ‐glutamyl transferase |
| سلسلة جزيئية: | ClinicalTrials.gov NCT03417050 |
| المشرفين على المادة: | EC 2.3.2.2 (gamma-Glutamyltransferase) |
| تواريخ الأحداث: | Date Created: 20240402 Date Completed: 20240417 Latest Revision: 20240724 |
| رمز التحديث: | 20240725 |
| مُعرف محوري في PubMed: | PMC11262495 |
| DOI: | 10.1161/JAHA.123.032276 |
| PMID: | 38563386 |
| قاعدة البيانات: | MEDLINE |
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