دورية أكاديمية
The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype.
| العنوان: | The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype. |
|---|---|
| المؤلفون: | Muir A; Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Bennett A; Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Smith H; Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Logunova L; Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Wolfenden A; School of Life Sciences, University of Nottingham, Nottingham, UK., Fenn J; School of Life Sciences, University of Nottingham, Nottingham, UK., Lowe AE; School of Life Sciences, University of Nottingham, Nottingham, UK., Brass A; School of Health Sciences, The University of Manchester, Manchester, UK., Grainger JR; Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Konkel JE; Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Bradley JE; School of Life Sciences, University of Nottingham, Nottingham, UK., Mair I; Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Else KJ; Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. |
| المصدر: | Discovery immunology [Discov Immunol] 2023 Apr 18; Vol. 2 (1), pp. kyad005. Date of Electronic Publication: 2023 Apr 18 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press on behalf of the British Society for Immunology Country of Publication: England NLM ID: 9918486782306676 Publication Model: eCollection Cited Medium: Internet ISSN: 2754-2483 (Electronic) Linking ISSN: 27542483 NLM ISO Abbreviation: Discov Immunol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : Oxford University Press on behalf of the British Society for Immunology, [2022]- |
| مستخلص: | The murine bone marrow has a central role in immune function and health as the primary source of leukocytes in adult mice. Laboratory mice provide a human-homologous, genetically manipulable and reproducible model that has enabled an immeasurable volume of high-quality immunological research. However, recent research has questioned the translatability of laboratory mouse research into humans and proposed that the exposure of mice to their wild and natural environment may hold the key to further immunological breakthroughs. To date, there have been no studies providing an in-depth cellular analysis of the wild mouse bone marrow. This study utilized wild mice from an isolated island population (Isle of May, Scotland, UK) and performed flow cytometric and histological analysis to characterize the myeloid, lymphoid, hematopoietic progenitor, and adipocyte compartments within the wild mouse bone marrow. We find that, compared to laboratory mouse bone marrow, the wild mouse bone marrow differs in every cell type assessed. Some of the major distinctions include; a smaller B cell compartment with an enriched presence of plasma cells, increased proportions of KLRG1+ CD8+ T cells, diminished CD11b expression in the myeloid lineage and a five-fold enlargement of the eosinophil compartment. We conclude that the wild mouse bone marrow is dramatically distinct from its laboratory counterparts, with multiple phenotypes that to our knowledge have never been observed in laboratory models. Further research into these unique features may uncover novel immunological mechanisms and grant a greater understanding of the role of the immune system in a natural setting. (© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Immunology.) |
| References: | Annu Rev Physiol. 2022 Feb 10;84:183-207. (PMID: 34614373) Nat Rev Immunol. 2017 Jan;17(1):21-29. (PMID: 27916977) Allergy. 2016 Feb;71(2):267-71. (PMID: 26414117) Microbiol Spectr. 2016 Oct;4(5):. (PMID: 27763252) Science. 2019 Aug 2;365(6452):. (PMID: 31371577) J Leukoc Biol. 2013 Oct;94(4):585-94. (PMID: 23543767) J Leukoc Biol. 2022 Jan;111(1):113-122. (PMID: 33857341) Immunity. 2018 Feb 20;48(2):364-379.e8. (PMID: 29466759) PLoS Biol. 2018 Apr 13;16(4):e2003538. (PMID: 29652925) Clin Exp Immunol. 2015 Nov;182(2):184-94. (PMID: 26153037) Immunology. 1999 Dec;98(4):604-11. (PMID: 10594695) Eur J Immunol. 2021 Dec;51(12):2708-3145. (PMID: 34910301) Exp Gerontol. 2013 Oct;48(10):1043-8. (PMID: 23376627) Arch Pathol Lab Med. 2016 Oct;140(10):1060-7. (PMID: 27684977) Immunity. 2016 Sep 20;45(3):597-609. (PMID: 27590115) J Immunol. 2014 Jan 1;192(1):27-33. (PMID: 24363432) J Virol. 2005 Sep;79(18):12112-6. (PMID: 16140789) Curr Opin Immunol. 2010 Jun;22(3):326-32. (PMID: 20116985) Age (Dordr). 2009 Dec;31(4):285-91. (PMID: 19479342) Ann Hematol. 2013 May;92(5):587-94. (PMID: 23307597) J Immunol Methods. 2007 Dec 1;328(1-2):189-200. (PMID: 17905303) J Leukoc Biol. 2017 Jan;101(1):321-328. (PMID: 27531929) Curr Opin Immunol. 2011 Aug;23(4):532-6. (PMID: 21872769) Cell. 2018 Jan 11;172(1-2):162-175.e14. (PMID: 29328911) Immunity. 2015 Jun 16;42(6):1130-42. (PMID: 26070484) Eur J Immunol. 2007 Jul;37(7):1796-808. (PMID: 17549732) Immunology. 2021 Dec;164(4):766-776. (PMID: 34486729) Eur J Immunol. 2014 Aug;44(8):2306-17. (PMID: 24777940) Front Endocrinol (Lausanne). 2018 Nov 28;9:694. (PMID: 30546345) Clin Exp Immunol. 2008 Oct;154(1):87-97. (PMID: 18727624) J Immunol. 2020 Sep 15;205(6):1479-1487. (PMID: 32900885) Cell. 2018 Jan 11;172(1-2):147-161.e12. (PMID: 29328910) Nat Commun. 2017 May 03;8:14811. (PMID: 28466840) J Immunol. 2017 Jul 15;199(2):383-388. (PMID: 28696328) Blood. 2013 Mar 7;121(10):1677-89. (PMID: 23305731) Nature. 2016 Apr 28;532(7600):512-6. (PMID: 27096360) Immunology. 2008 Nov;125(3):281-8. (PMID: 19128361) Biogerontology. 2001;2(3):165-71. (PMID: 11708718) J Leukoc Biol. 2020 Mar;107(3):367-377. (PMID: 31674692) Exp Gerontol. 2010 Apr;45(4):286-90. (PMID: 20034552) PLoS Pathog. 2010 Jun 10;6(6):e1000947. (PMID: 20548953) Adipocyte. 2017 Jul 3;6(3):193-204. (PMID: 28872979) Cytometry A. 2012 Apr;81(4):343-50. (PMID: 22213571) Trends Immunol. 2016 May;37(5):321-333. (PMID: 27055914) J Leukoc Biol. 2022 May;111(5):943-952. (PMID: 35141942) |
| فهرسة مساهمة: | Keywords: bone marrow; ecoimmunology; flow cytometry; hematopoietic progenitors; leukocytes; wild mouse |
| تواريخ الأحداث: | Date Created: 20240403 Latest Revision: 20240404 |
| رمز التحديث: | 20240404 |
| مُعرف محوري في PubMed: | PMC10917185 |
| DOI: | 10.1093/discim/kyad005 |
| PMID: | 38567065 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2754-2483 |
|---|---|
| DOI: | 10.1093/discim/kyad005 |