دورية أكاديمية
Incidence of Influenza-related Medical Encounters and the Associated Healthcare Resource Use and Complications Across Adult Age Groups in the United States During the 2015-2020 Influenza Seasons.
| العنوان: | Incidence of Influenza-related Medical Encounters and the Associated Healthcare Resource Use and Complications Across Adult Age Groups in the United States During the 2015-2020 Influenza Seasons. |
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| المؤلفون: | McGovern I; CSL Seqirus, Center for Outcomes Research and Epidemiology, Waltham, Massachusetts, USA., Cappell K; Veradigm, Real World Evidence, Chicago, Illinois, USA., Bogdanov AN; Veradigm, Real World Evidence, Chicago, Illinois, USA., Haag MDM; CSL Seqirus, Center for Outcomes Research and Epidemiology, Amsterdam, The Netherlands. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Sep 26; Vol. 79 (3), pp. 778-786. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Influenza, Human*/epidemiology , Hospitalization*/statistics & numerical data , Seasons*, Humans ; Adult ; Middle Aged ; United States/epidemiology ; Incidence ; Male ; Female ; Young Adult ; Adolescent ; Aged ; Retrospective Studies ; Emergency Service, Hospital/statistics & numerical data ; Aged, 80 and over ; Age Factors ; Health Resources/statistics & numerical data |
| مستخلص: | Background: Research on influenza burden in adults has focused on crude subgroups with cut-points at 65 years, limiting insight into how burden varies with increasing age. This study describes the incidence of influenza-related outpatient visits, emergency room visits, and hospitalizations, along with healthcare resource use and complications in the aging adult population. Methods: Individuals aged ≥18 years in the United States were evaluated retrospectively in 5 seasonal cohorts (2015-2020 seasons) in strata of age with 5-year increments. Person-level electronic medical records linked to pharmacy and medical claims were used to ascertain patient characteristics and outcomes. Influenza-related medical encounters were identified based on diagnostic codes (International Classification of Diseases, 10th Edition, codes J09*-J11*). Results: Incidence of influenza-related outpatient visits was highest among people aged 18-34 years and declined with increasing age. For emergency room visits, incidence tended to be elevated for people aged 18-34 years, relatively stable from 35 through 60, and increased rapidly after age 60 years. Hospitalization incidence remained relatively stable until about 50 years of age and then increased with age. One in 3 patients was diagnosed with pneumonia after hospitalization, regardless of age. Across seasons, age groups, and clinical settings, on average, 40.8% of individuals were prescribed antivirals and 17.2% antibiotics. Conclusions: Incidence of influenza-related hospitalizations begins to increase around age 50 years rather than the more common cut-point of 65, whereas incidence of outpatient visits was highest among younger adults. Influenza infections frequently led to antiviral and antibiotic prescriptions, underscoring the role influenza vaccination can play in combating antimicrobial resistance. Competing Interests: Potential conflicts of interest . I. M. and M. H. are employees of CSL Seqirus. K. C. and A. B. work for Veradigm, a company that was contracted by CSL Seqirus and received a research contract to conduct this study with and on behalf of CSL Seqirus. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
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| معلومات مُعتمدة: | CSL Seqirus |
| فهرسة مساهمة: | Keywords: Antibiotics; Antivirals; Disease Burden; Incidence; Influenza |
| تواريخ الأحداث: | Date Created: 20240403 Date Completed: 20240926 Latest Revision: 20240928 |
| رمز التحديث: | 20240928 |
| مُعرف محوري في PubMed: | PMC11426264 |
| DOI: | 10.1093/cid/ciae180 |
| PMID: | 38567481 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciae180 |