دورية أكاديمية
أعرض في EDS

Dysregulated AEBP1 and COLEC12 Genes in Late-Onset Alzheimer's Disease: Insights from Brain Cortex and Peripheral Blood Analysis.

التفاصيل البيبلوغرافية
العنوان: Dysregulated AEBP1 and COLEC12 Genes in Late-Onset Alzheimer's Disease: Insights from Brain Cortex and Peripheral Blood Analysis.
المؤلفون: Asadie M; Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran., Miri A; Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran., Badri T; Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran., Hosseini Nejad J; Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran., Gharechahi J; Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. jgharechahi@bmsu.ac.ir.
المصدر: Journal of molecular neuroscience : MN [J Mol Neurosci] 2024 Apr 03; Vol. 74 (2), pp. 37. Date of Electronic Publication: 2024 Apr 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9002991 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1166 (Electronic) Linking ISSN: 08958696 NLM ISO Abbreviation: J Mol Neurosci Subsets: MEDLINE
أسماء مطبوعة: Publication: Totowa, NJ : Humana Press
Original Publication: Boston : Birkhäuser [i.e. Cambridge, MA : Birkhäuser Boston, c1989-
مواضيع طبية MeSH: Alzheimer Disease*/genetics, Humans ; Brain ; Temporal Lobe ; Frontal Lobe ; Entorhinal Cortex ; Late Onset Disorders ; Collectins ; Receptors, Scavenger ; Carboxypeptidases ; Repressor Proteins
مستخلص: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory and cognitive impairment, often accompanied by alterations in mood, confusion, and, ultimately, a state of acute mental disturbance. The cerebral cortex is considered a promising area for investigating the underlying causes of AD by analyzing transcriptional patterns, which could be complemented by investigating blood samples obtained from patients. We analyzed the RNA expression profiles of three distinct areas of the brain cortex, including the frontal cortex (FC), temporal cortex (TC), and entorhinal cortex (EC) in patients with AD. Functional enrichment analysis was performed on the differentially expressed genes (DEGs) across the three regions. The two genes with the most significant expression changes in the EC region were selected for assessing mRNA expression levels in the peripheral blood of late-onset AD patients using quantitative PCR (qPCR). We identified eight shared DEGs in these regions, including AEBP1 and COLEC12, which exhibited prominent changes in expression. Functional enrichment analysis uncovered a significant association of these DEGs with the transforming growth factor-β (TGF-β) signaling pathway and processes related to angiogenesis. Importantly, we established a robust connection between the up-regulation of AEBP1 and COLEC12 in both the brain and peripheral blood. Furthermore, we have demonstrated the potential of AEBP1 and COLEC12 genes as effective diagnostic tools for distinguishing between late-onset AD patients and healthy controls. This study unveils the intricate interplay between AEBP1 and COLEC12 in AD and underscores their potential as markers for disease detection and monitoring.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: AEBP1; COLEC12; Alzheimer’s disease; Brain cortex; Diagnosis; mRNA expression profile
المشرفين على المادة: 0 (COLEC12 protein, human)
0 (Collectins)
0 (Receptors, Scavenger)
0 (AEBP1 protein, human)
EC 3.4.- (Carboxypeptidases)
0 (Repressor Proteins)
تواريخ الأحداث: Date Created: 20240403 Date Completed: 20240404 Latest Revision: 20240719
رمز التحديث: 20240719
DOI: 10.1007/s12031-024-02212-8
PMID: 38568322
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-1166
DOI:10.1007/s12031-024-02212-8