دورية أكاديمية
Symmetric dimethylarginine correlates with the urea, creatinine, potassium, and clinical scores in feline urethral obstructions.
| العنوان: | Symmetric dimethylarginine correlates with the urea, creatinine, potassium, and clinical scores in feline urethral obstructions. |
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| المؤلفون: | Nóbrega JCD; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Dinallo HR; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Geraldes SS; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Azevedo MGP; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Moraes RS; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Maia SR; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Souza FF; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Melchert A; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., García HDM; Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Andreatti Filho RL; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Okamoto AS; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil., Okamoto PTCG; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, 18618-681, São Paulo, Brazil. tatiana.okamoto@unesp.br. |
| المصدر: | Journal of veterinary science [J Vet Sci] 2024 Mar; Vol. 25 (2), pp. e27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Society of Veterinary Science Country of Publication: Korea (South) NLM ID: 100964185 Publication Model: Print Cited Medium: Internet ISSN: 1976-555X (Electronic) Linking ISSN: 1229845X NLM ISO Abbreviation: J Vet Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul : Korean Society of Veterinary Science, 2000- |
| مواضيع طبية MeSH: | Renal Insufficiency, Chronic*/veterinary , Cat Diseases*/diagnosis, Arginine/*analogs & derivatives, Cats ; Animals ; Male ; Creatinine ; Urea ; Potassium ; Bicarbonates ; Biomarkers |
| مستخلص: | Background: A urethral obstruction (UO) is an emergency commonly observed in male cats, which can result in significant clinical and laboratory alterations, leading to complications and death. Objectives: This study aimed to correlate symmetric dimethylarginine (SDMA) with the urea, creatinine, potassium, and bicarbonate levels in cats with UO. In addition, the correlation between clinical score and time of obstruction was evaluated. Methods: Thirty male cats were selected and allocated into a control group (CG, n = 13) and an obstruction group (OG, n = 17). The laboratory analyses were conducted before treatment (M0) and at different times after treatment (12 h [M12], 24 h [M24], and 48 h [M48]). Correlations were established between SDMA and creatinine, urea, bicarbonate, potassium, time of obstruction, and the clinical score. Results: A strong correlation (r > 0.6) was observed between SDMA and creatinine, urea, and potassium in the OG. Furthermore, there was substantial agreement (kappa value) between SDMA and creatinine at M24. A higher clinical score was associated with a longer time of obstruction. In the OG, at M48, the SDMA and creatinine levels were 50% and 41.2% higher, respectively. Conclusions: A correlation was observed between SDMA and creatinine in obstructed cats, and significant agreement between these values was observed 24 h after the unblocking treatment. A correlation among SDMA, urea, and potassium was observed. Approximately 9% more cats continued to have elevated SDMA levels after 48 h of treatment compared to creatinine. This suggests a slightly lower sensitivity of the latter biomarker but does not exclude the possibility of congruent and normalized values after a longer evaluation period. Competing Interests: The authors declare no conflicts of interest. (© 2024 The Korean Society of Veterinary Science.) |
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| معلومات مُعتمدة: | Brazil CAPES Coordination for the Improvement of Higher Education Personnel |
| فهرسة مساهمة: | Keywords: Biomarker; Felis catus; kidney; urethra |
| المشرفين على المادة: | AYI8EX34EU (Creatinine) 8W8T17847W (Urea) 49787G1ULV (symmetric dimethylarginine) RWP5GA015D (Potassium) 0 (Bicarbonates) 0 (Biomarkers) 94ZLA3W45F (Arginine) |
| تواريخ الأحداث: | Date Created: 20240403 Date Completed: 20240405 Latest Revision: 20240406 |
| رمز التحديث: | 20240406 |
| مُعرف محوري في PubMed: | PMC10990919 |
| DOI: | 10.4142/jvs.23268 |
| PMID: | 38568828 |
| قاعدة البيانات: | MEDLINE |
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