دورية أكاديمية
أعرض في EDS

Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol.

التفاصيل البيبلوغرافية
العنوان: Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol.
المؤلفون: Travaglianti S; University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Toledo, OH 43614, USA., Alotaibi A; University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Toledo, OH 43614, USA., Wong W; University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Toledo, OH 43614, USA., Abou-Gharbia M; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA., Childers W; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA., Sari Y; University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Toledo, OH 43614, USA. Electronic address: youssef.sari@utoledo.edu.
المصدر: Brain research bulletin [Brain Res Bull] 2024 Jun 01; Vol. 211, pp. 110935. Date of Electronic Publication: 2024 Apr 01.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Elsevier Science
Original Publication: Phoenix, N. Y. ANKHO International Inc.
مواضيع طبية MeSH: Excitatory Amino Acid Transporter 2*/metabolism , Ethanol*/pharmacology , Prefrontal Cortex*/metabolism , Prefrontal Cortex*/drug effects , Nucleus Accumbens*/drug effects , Nucleus Accumbens*/metabolism, Animals ; Male ; Rats ; Neuroinflammatory Diseases/drug therapy ; Neuroinflammatory Diseases/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Biomarkers/metabolism ; Alcohol Drinking/metabolism ; Alcohol Drinking/drug therapy ; Alcoholism/drug therapy ; Alcoholism/metabolism ; Brain/metabolism ; Brain/drug effects
مستخلص: Chronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mPFC) and nucleus accumbens (NAc), and consequently leading to oxidative stress and neuroinflammation. Previous studies from our lab tested β-lactam antibiotics and novel beta-lactam non-antibiotic, MC-100093, and showed these β-lactam upregulated the major astrocytic glutamate transporter, GLT-1, and consequently reduced ethanol intake and normalized glutamate homeostasis. This present study tested the effects of novel synthetic β-lactam non-antibiotic drug, MC-100093, in chronic ethanol intake and neuroinflammatory and trophic factors in subregions of the NAc (NAc core and shell) and mPFC (Prelimbic, PL; and Infralimbic, IL) of male P rats. MC-100093 treatment reduced ethanol intake after 5-week drinking regimen. Importantly, MC-100093 attenuated ethanol-induced downregulation of brain derived neurotrophic factor (BDNF) expression in these brain regions. In addition, MC-100093 attenuated ethanol-induced upregulation of pro-inflammatory cytokines such as TNF-a and HMGB1 in all these brain regions. Furthermore, MC-100093 treatment attenuated ethanol-induced increase in RAGE in these brain regions. MC-100093 prevented neuroinflammation caused by ethanol intake as well as increased neurotrophic factor in mesocorticolimbic brain regions. MC-100093 treatment reduced ethanol intake and this behavioral effect was associated with attenuation of reduced trophic factors and increased pro-inflammatory factors. MC-100093 is considered a small molecule that may have potential therapeutic effects for the treatment of the effects of chronic exposure to ethanol.
Competing Interests: Declaration of Competing Interest The authors declare that they have no financial interests or personal relationships in the work reported in this research article.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
References: Biol Psychiatry. 2013 Apr 1;73(7):602-12. (PMID: 23206318)
J Mol Neurosci. 2019 Jan;67(1):1-15. (PMID: 30471010)
PLoS One. 2013;8(3):e60290. (PMID: 23536907)
PLoS One. 2013;8(1):e53793. (PMID: 23326507)
Neuroscience. 2003;118(2):451-62. (PMID: 12699781)
Neuroscience. 2012 Dec 27;227:327-35. (PMID: 23059796)
Curr Neuropharmacol. 2022;20(11):2202-2220. (PMID: 35748555)
Neuroscience. 2013 Nov 12;252:190-200. (PMID: 23933309)
Brain Res. 2015 Dec 2;1628(Pt A):68-81. (PMID: 25451116)
J Pharmacol Exp Ther. 2021 Aug;378(2):51-59. (PMID: 33986035)
Brain Res Bull. 2020 Dec;165:272-280. (PMID: 33075417)
Front Neurosci. 2018 Sep 11;12:628. (PMID: 30271319)
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:1-8. (PMID: 28347687)
Front Mol Neurosci. 2019 Jan 09;11:490. (PMID: 30687006)
Int J Mol Sci. 2020 Jun 29;21(13):. (PMID: 32610502)
Acta Neuropathol Commun. 2021 Sep 28;9(1):159. (PMID: 34625123)
Alcohol Alcohol Suppl. 1987;1:91-6. (PMID: 3426760)
Genomics Inform. 2013 Dec;11(4):224-9. (PMID: 24465234)
Alcohol. 2014 May;48(3):209-15. (PMID: 24268381)
Alcohol Alcohol. 2011 May-Jun;46(3):239-46. (PMID: 21422004)
Addict Biol. 2006 Sep;11(3-4):270-88. (PMID: 16961759)
Neuropharmacology. 2015 Oct;97:67-74. (PMID: 26002627)
Behav Brain Res. 2017 Aug 14;332:288-298. (PMID: 28624317)
Biol Psychiatry. 2016 Mar 15;79(6):463-73. (PMID: 26204799)
J Neurosci. 2008 Mar 5;28(10):2589-600. (PMID: 18322102)
Brain Pathol. 2004 Oct;14(4):365-71. (PMID: 15605983)
PLoS One. 2013 Aug 09;8(8):e70945. (PMID: 23951048)
Int Rev Neurobiol. 2014;118:315-57. (PMID: 25175868)
Brain Res. 2012 May 25;1456:14-21. (PMID: 22521042)
J Neurosci. 2014 Mar 26;34(13):4581-8. (PMID: 24672003)
Neuroscience. 2015 Jun 4;295:164-74. (PMID: 25813713)
Brain Res. 2005 Feb 9;1034(1-2):11-24. (PMID: 15713255)
Brain Res. 2015 Oct 5;1622:397-408. (PMID: 26168897)
Front Neural Circuits. 2020 Jun 30;14:37. (PMID: 32694984)
Psychopharmacology (Berl). 2020 Jul;237(7):2007-2018. (PMID: 32382781)
J Neurochem. 2009 Jun;109(5):1459-68. (PMID: 19453942)
J Neuroinflammation. 2012 Jun 18;9:130. (PMID: 22709825)
Neurochem Int. 2019 Jan;122:31-37. (PMID: 30392874)
Neurosci Res. 2002 Jul;43(3):193-9. (PMID: 12103437)
Biol Psychiatry. 2010 Jan 1;67(1):81-4. (PMID: 19717140)
Pharmacol Biochem Behav. 2018 Jul;170:44-55. (PMID: 29753887)
Commun Integr Biol. 2011 Jan;4(1):14-6. (PMID: 21509169)
Biomolecules. 2020 Jul 10;10(7):. (PMID: 32664441)
Biol Psychiatry. 2011 Sep 15;70(6):575-82. (PMID: 21549353)
J Pharmacol Exp Ther. 2022 Dec;383(3):208-216. (PMID: 36153003)
J Neurosci. 2009 Jul 22;29(29):9239-43. (PMID: 19625514)
Alcohol. 1986 Sep-Oct;3(5):331-6. (PMID: 3778650)
Toxicology. 2013 Sep 6;311(1-2):27-34. (PMID: 23500890)
Behav Brain Res. 2018 Jul 16;347:368-376. (PMID: 29604365)
Ann N Y Acad Sci. 2008 Nov;1144:97-112. (PMID: 19076369)
معلومات مُعتمدة: R01 AA029674 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: BDNF; Ethanol dependence; MC-100093; Neuroinflammation; TNF-α
المشرفين على المادة: 0 (Excitatory Amino Acid Transporter 2)
3K9958V90M (Ethanol)
0 (Slc1a2 protein, rat)
0 (Brain-Derived Neurotrophic Factor)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240403 Date Completed: 20240427 Latest Revision: 20240603
رمز التحديث: 20240603
مُعرف محوري في PubMed: PMC11056292
DOI: 10.1016/j.brainresbull.2024.110935
PMID: 38570076
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2747
DOI:10.1016/j.brainresbull.2024.110935