دورية أكاديمية
Reactivation of herpesvirus type 6 and IgA/IgM-mediated responses to activin-A underpin long COVID, including affective symptoms and chronic fatigue syndrome.
| العنوان: | Reactivation of herpesvirus type 6 and IgA/IgM-mediated responses to activin-A underpin long COVID, including affective symptoms and chronic fatigue syndrome. |
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| المؤلفون: | Vojdani A; Immunosciences Lab, Inc., Los Angeles, CA90035, USA.; Cyrex Laboratories, LLC, Phoenix, AZ85034, USA., Almulla AF; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand.; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq., Zhou B; Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu610072, China.; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu610072, China., Al-Hakeim HK; Department of Chemistry, College of Science, University of Kufa, Kufa, Iraq., Maes M; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand.; Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu610072, China.; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu610072, China.; Cognitive Impairment and Dementia Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria.; Research Center, Medical University of Plovdiv, Plovdiv, Bulgaria.; Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul02447, Korea. |
| المصدر: | Acta neuropsychiatrica [Acta Neuropsychiatr] 2024 Jun; Vol. 36 (3), pp. 172-184. Date of Electronic Publication: 2024 Apr 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 9612501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-5215 (Electronic) Linking ISSN: 09242708 NLM ISO Abbreviation: Acta Neuropsychiatr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013- : Cambridge, United Kingdom : Cambridge University Press Original Publication: Maarssen : Interdisciplinair Genootschap voor Biologische Psychiatrie |
| مواضيع طبية MeSH: | Herpesvirus 6, Human*/immunology , Fatigue Syndrome, Chronic*/blood , Fatigue Syndrome, Chronic*/immunology , Fatigue Syndrome, Chronic*/virology , Immunoglobulin A*/blood , Immunoglobulin M*/blood , COVID-19*/immunology , COVID-19*/blood , Activins*/blood , SARS-CoV-2*/immunology, Humans ; Male ; Female ; Adult ; Middle Aged ; Post-Acute COVID-19 Syndrome ; Antibodies, Viral/blood ; Herpesvirus 4, Human/immunology ; Biomarkers/blood ; Roseolovirus Infections/blood ; Roseolovirus Infections/immunology |
| مستخلص: | Background: Persistent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reactivation of dormant viruses, and immune-oxidative responses are involved in long COVID. Objectives: To investigate whether long COVID and depressive, anxiety, and chronic fatigue syndrome (CFS) symptoms are associated with IgA/IgM/IgG to SARS-CoV-2, human herpesvirus type 6 (HHV-6), Epstein-Barr Virus (EBV), and immune-oxidative biomarkers. Methods: We examined 90 long COVID patients and ninety healthy controls. We measured serum IgA/IgM/IgG against HHV-6 and EBV and their deoxyuridine 5′-triphosphate nucleotidohydrolase (duTPase), SARS-CoV-2, and activin-A, C-reactive protein (CRP), advanced oxidation protein products (AOPP), and insulin resistance (HOMA2-IR). Results: Long COVID patients showed significant elevations in IgG/IgM-SARS-CoV-2, IgG/IgM-HHV-6, and HHV-6-duTPase, IgA/IgM-activin-A, CRP, AOPP, and HOMA2-IR. Neural network analysis yielded a highly significant predictive accuracy of 80.6% for the long COVID diagnosis (sensitivity: 78.9%, specificity: 81.8%, area under the ROC curve = 0.876); the topmost predictors were as follows: IGA-activin-A, IgG-HHV-6, IgM-HHV-6-duTPase, IgG-SARS-CoV-2, and IgM-HHV-6 (all positively) and a factor extracted from all IgA levels to all viral antigens (inversely). The top 5 predictors of affective symptoms due to long COVID were IgM-HHV-6-duTPase, IgG-HHV-6, CRP, education, IgA-activin-A (predictive accuracy of r = 0.636). The top 5 predictors of CFS due to long COVID were in descending order: CRP, IgG-HHV-6-duTPase, IgM-activin-A, IgM-SARS-CoV-2, and IgA-activin-A (predictive accuracy: r = 0.709). Conclusion: Reactivation of HHV-6, SARS-CoV-2 persistence, and autoimmune reactions to activin-A combined with activated immune-oxidative pathways play a major role in the pathophysiology of long COVID as well as the severity of its affective symptoms and CFS. |
| فهرسة مساهمة: | Keywords: Affective disorders; chronic fatigue syndrome; depression; long COVID; neuroimmune; oxidative stress |
| المشرفين على المادة: | 0 (activin A) |
| تواريخ الأحداث: | Date Created: 20240404 Date Completed: 20240520 Latest Revision: 20240520 |
| رمز التحديث: | 20240520 |
| DOI: | 10.1017/neu.2024.10 |
| PMID: | 38571295 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1601-5215 |
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| DOI: | 10.1017/neu.2024.10 |