دورية أكاديمية
Harzianic acids and oxazolidinone from the endophytic fungus Ilyonectria sp. and their cytotoxicity activity.
| العنوان: | Harzianic acids and oxazolidinone from the endophytic fungus Ilyonectria sp. and their cytotoxicity activity. |
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| المؤلفون: | Tong SY; School of Pharmaceutical Science, South-Central Minzu University, Wuhan, Hubei 430074, China., Ye K; School of Pharmaceutical Science, South-Central Minzu University, Wuhan, Hubei 430074, China., Wang WX; School of Pharmacy, Chongqing Three Gorges Medical College, Chongqing 404120, China. Electronic address: wangwenxiang@cqtgmc.edu.cn., Ai HL; School of Pharmaceutical Science, South-Central Minzu University, Wuhan, Hubei 430074, China. Electronic address: aihonglian05@163.com. |
| المصدر: | Fitoterapia [Fitoterapia] 2024 Jun; Vol. 175, pp. 105941. Date of Electronic Publication: 2024 Apr 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| مواضيع طبية MeSH: | Molecular Docking Simulation* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/isolation & purification , Antineoplastic Agents*/chemistry , Oxazolidinones*/pharmacology , Oxazolidinones*/isolation & purification, Humans ; Cell Line, Tumor ; Molecular Structure ; Endophytes/chemistry ; China ; Hypocreales/chemistry |
| مستخلص: | Four undescribed compounds including three harzianic acids (1, 3 and 4) and one oxazolidinone (2), along with three known ones (5-7) were isolated from the solid fermented product of endophytic fungus Ilyonectria sp., their structures were elucidated as 1-amino-harzianic acid (1), ilyonectria-oxazolidinone (2),10'-nor- isoharzianic acid (3), isohomoharzianic acid (4), harzianic acid (5), isoharzianic acid (6), homoharzianic acid (7) by means of detailed chemical evidences and spectroscopic data analysis. All the compounds were evaluated for cytotoxicity against SMMC-7721 human cancer cell lines by MTS assay. Among the seven tested compounds, 1-amino-harzianic acid (1) demonstrated well cytotoxic activity against SMMC-7721 with IC Competing Interests: Declaration of competing interest The authors declared that they have no conflicts of interest to this work. We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted. (Copyright © 2023. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Bletilla striata; Chemical constituents; Endophytic fungus; Ilyonectria sp. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Oxazolidinones) |
| تواريخ الأحداث: | Date Created: 20240404 Date Completed: 20240524 Latest Revision: 20240524 |
| رمز التحديث: | 20240525 |
| DOI: | 10.1016/j.fitote.2024.105941 |
| PMID: | 38575089 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6971 |
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| DOI: | 10.1016/j.fitote.2024.105941 |