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Adiposity, Body Composition Measures, and Breast Cancer Risk in Korean Premenopausal Women.

التفاصيل البيبلوغرافية
العنوان: Adiposity, Body Composition Measures, and Breast Cancer Risk in Korean Premenopausal Women.
المؤلفون: Tran TXM; Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea., Chang Y; Center for Cohort Studies, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea., Choi HR; Center for Cohort Studies, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Institute of Medical Research, Sungkyunkwan University, School of Medicine, Suwon, Republic of Korea., Kwon R; Center for Cohort Studies, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Institute of Medical Research, Sungkyunkwan University, School of Medicine, Suwon, Republic of Korea., Lim GY; Center for Cohort Studies, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Institute of Medical Research, Sungkyunkwan University, School of Medicine, Suwon, Republic of Korea., Kim EY; Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Ryu S; Center for Cohort Studies, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea., Park B; Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.; Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, Republic of Korea.
المصدر: JAMA network open [JAMA Netw Open] 2024 Apr 01; Vol. 7 (4), pp. e245423. Date of Electronic Publication: 2024 Apr 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Chicago, IL : American Medical Association, [2018]-
مواضيع طبية MeSH: Adiposity*/physiology , Breast Neoplasms*/etiology , Breast Neoplasms*/complications, Female ; Humans ; Cohort Studies ; Prospective Studies ; Risk Factors ; Obesity/complications ; Body Composition ; Republic of Korea/epidemiology
مستخلص: Objective: To investigate the association between body composition parameters and breast cancer (BC) risk in premenopausal women.
Design, Setting, and Participants: Prospective cohort study using data from the Kangbuk Samsung Cohort Study. Participants were women aged 20 to 54 years who were enrolled from 2011 to 2019 and followed up for BC development until December 31, 2020. Data were analyzed from June to August 2023.
Exposures: Trained nurses conducted anthropometric measurements and assessed body composition using segmental bioelectric impedance analysis. The analysis encompassed adiposity measures such as body mass index (BMI), waist circumference, and body composition parameters, including muscle mass, fat mass, ratio of muscle mass to weight, ratio of fat mass to weight, and fat mass index.
Main Outcomes and Measures: Adjusted hazard ratios (aHR) for BC during the follow-up period.
Results: Among 125 188 premenopausal women, the mean (SD) age was 34.9 (6.3) years. During a mean (range) follow-up of 6.7 (0.5-9.9) years, 1110 incident BC cases were identified. The mean (SD) BMI and waist circumference were 21.6 (3.1) and 75.3 (8.2) cm, respectively. Higher BMI and waist circumference were associated with decreased risk, with an aHR of 0.89 (95% CI, 0.84-0.95) per SD increase in BMI and 0.92 (95% CI, 0.86-0.98) per SD increase in waist circumference. A higher ratio of fat mass to weight was associated with decreased BC risk (aHR, 0.92; 95% CI, 0.86-0.99 per SD increase), whereas the opposite trend was observed for the ratio of muscle mass to weight, with an aHR of 1.08 (95% CI, 1.02-1.15) per SD increase. The results remained consistent even after additional adjustments for height in the model. The fat mass index was also inversely associated with BC risk, with an HR of 0.90 (95% CI, 0.85-0.97) per SD increase.
Conclusions and Relevance: In this cohort study of premenopausal women, a higher level of adiposity, represented by increased BMI, waist circumference, and fat mass, was consistently associated with decreased breast cancer risk. Conversely, muscle mass and its ratio to weight displayed opposite or inconsistent patterns. These findings suggest an inverse association between excess adiposity and the risk of BC in premenopausal women, confirming earlier findings that BMI is an indirect measure of adiposity.
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تواريخ الأحداث: Date Created: 20240405 Date Completed: 20240408 Latest Revision: 20240627
رمز التحديث: 20240627
مُعرف محوري في PubMed: PMC10998159
DOI: 10.1001/jamanetworkopen.2024.5423
PMID: 38578637
قاعدة البيانات: MEDLINE
الوصف
تدمد:2574-3805
DOI:10.1001/jamanetworkopen.2024.5423