دورية أكاديمية
Serum microRNA‑122 for assessment of acute liver injury in patients with extensive skeletal muscle damage.
| العنوان: | Serum microRNA‑122 for assessment of acute liver injury in patients with extensive skeletal muscle damage. |
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| المؤلفون: | Zhang Y; University of Texas MD Anderson Cancer Center Division of Pathology and Laboratory Medicine, Houston, TX, US., Ong CM; University of California San Francisco - Laboratory Medicine, San Francisco, CA, US., Lynch K; Department of Medicine, University of California San Francisco, San Francisco, CA, US.; University of California San Francisco Medical Center at Parnassus - Laboratory Medicine, San Francisco, CA, US., Waksman J; Department of Medicine, University of California San Francisco, San Francisco, CA, US., Wu AHB; University of California San Francisco Medical Center at Parnassus - Laboratory Medicine, San Francisco, CA, US. |
| المصدر: | Laboratory medicine [Lab Med] 2024 Sep 04; Vol. 55 (5), pp. 609-614. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0250641 Publication Model: Print Cited Medium: Internet ISSN: 1943-7730 (Electronic) Linking ISSN: 00075027 NLM ISO Abbreviation: Lab Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oct. 2015- : Oxford, England: Oxford University Press Original Publication: Philadelphia, Lippincott. |
| مواضيع طبية MeSH: | MicroRNAs*/blood , Chemical and Drug Induced Liver Injury*/blood , Chemical and Drug Induced Liver Injury*/diagnosis , Biomarkers*/blood, Humans ; Male ; Adult ; Female ; Middle Aged ; Aspartate Aminotransferases/blood ; Alanine Transaminase/blood ; Muscle, Skeletal/injuries ; Creatine Kinase/blood ; Young Adult |
| مستخلص: | Background: Serum level of microRNA-122 (miR-122) has been reported as a sensitive diagnostic biomarker for detecting liver injury, comparable to the aminotransferases. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities are increased in other conditions, such as acute skeletal muscle injury (ASMI). We determined whether miR-122 is nonspecifically increased in patients suffering from ASMI. Methods: We measured ALT, AST, creatine kinase (CK), and miR-122 in 3 groups: healthy controls (n = 24), patients with ASMI (total n = 29, 11 with recreational drug use and 18 without recreational drug use), and patients with acute liver injury (ALI; n = 14). Results: Levels of ALT, AST, and CK increased 83%, 97%, and 100% for patients with ASMI and 100% for all 3 enzymes in ALI patients. In contrast, miR-122 increased in 34% of patients with ASMI (44.4% with recreational drug use and 18.2% without recreational drug use) and 100% of ALI patients. In 2 drug-induced liver injury cases, miR-122 increased about 12-24 hours before ALT and AST. Conclusion: Recreational drug misuse is associated with both rhabdomyolysis and drug-induced liver injury (DILI). The traditional liver function markers AST and ALT were nonspecifically increased in the majority of patients with ASMI. miR-122 is only increased in patients at risk for DILI and demonstrates superior specificity for liver injury. (© The Author(s) 2024. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: acute liver injury; acute skeletal muscle injury; biomarker; miR-122 |
| المشرفين على المادة: | 0 (MIRN122 microRNA, human) 0 (MicroRNAs) 0 (Biomarkers) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) EC 2.7.3.2 (Creatine Kinase) |
| تواريخ الأحداث: | Date Created: 20240405 Date Completed: 20240904 Latest Revision: 20240904 |
| رمز التحديث: | 20240904 |
| DOI: | 10.1093/labmed/lmae022 |
| PMID: | 38578664 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1943-7730 |
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| DOI: | 10.1093/labmed/lmae022 |