دورية أكاديمية
أعرض في EDS

Extrasynaptic GABA A receptors in central medial thalamus mediate anesthesia in rats.

التفاصيل البيبلوغرافية
العنوان: Extrasynaptic GABA A receptors in central medial thalamus mediate anesthesia in rats.
المؤلفون: Muheyati A; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China., Jiang S; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China., Wang N; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China., Yu G; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China. Electronic address: yg1st@163.com., Su R; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China. Electronic address: ruibinsu@126.com.
المصدر: European journal of pharmacology [Eur J Pharmacol] 2024 Jun 05; Vol. 972, pp. 176561. Date of Electronic Publication: 2024 Apr 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Amsterdam : Elsevier Science
Original Publication: Amsterdam, North Holland Pub. Co.
مواضيع طبية MeSH: Receptors, GABA-A*/metabolism , Isoxazoles*/pharmacology , Anesthesia*, Animals ; Male ; Rats ; Diazepam/pharmacology ; Rats, Sprague-Dawley ; Mediodorsal Thalamic Nucleus/drug effects ; Mediodorsal Thalamic Nucleus/metabolism ; Mediodorsal Thalamic Nucleus/physiology ; Reflex, Righting/drug effects ; Synapses/drug effects ; Synapses/metabolism ; Thalamus/drug effects ; Thalamus/metabolism
مستخلص: Neuronal depression in the thalamus underlies anesthetic-induced loss of consciousness, while the precise sub-thalamus nuclei and molecular targets involved remain to be elucidated. The present study investigated the role of extrasynaptic GABA A receptors in the central medial thalamic nucleus (CM) in anesthesia induced by gaboxadol (THIP) and diazepam (DZP) in rats. Local lesion of the CM led to a decrease in the duration of loss of righting reflex induced by THIP and DZP. CM microinjection of THIP but not DZP induced anesthesia. The absence of righting reflex in THIP-treated rats was consistent with the increase of low frequency oscillations in the delta band in the medial prefrontal cortex. CM microinjection of GABA A receptor antagonist SR95531 significantly attenuated the anesthesia induced by systemically-administered THIP, but not DZP. Moreover, the rats with declined expression of GABA A receptor δ-subunit in the CM were less responsive to THIP or DZP. These findings explained a novel mechanism of THIP-induced loss of consciousness and highlighted the role of CM extrasynaptic GABA A receptors in mediating anesthesia.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Central medial thalamic nucleus; Diazepam; Gaboxadol; Loss of righting reflex
المشرفين على المادة: 0 (Receptors, GABA-A)
0 (Isoxazoles)
K1M5RVL18S (gaboxadol)
Q3JTX2Q7TU (Diazepam)
تواريخ الأحداث: Date Created: 20240405 Date Completed: 20240426 Latest Revision: 20240426
رمز التحديث: 20240427
DOI: 10.1016/j.ejphar.2024.176561
PMID: 38580182
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0712
DOI:10.1016/j.ejphar.2024.176561