دورية أكاديمية
Secondary plasma cell leukaemia (PCL) with plasmablastic morphology.
| العنوان: | Secondary plasma cell leukaemia (PCL) with plasmablastic morphology. |
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| المؤلفون: | Xu K; Department of Haematology, University College London Hospitals NHS Foundation Trust, University College London, 250 Euston Road, London, NW1 2PG, UK. Ke.xu@nhs.net.; Specialist Integrated Haematology Malignancy Diagnostic Service, Health Services Laboratories, University College London Hospitals NHS Foundation Trust, University College London, London, UK. Ke.xu@nhs.net., Nacheva E; Specialist Integrated Haematology Malignancy Diagnostic Service, Health Services Laboratories, University College London Hospitals NHS Foundation Trust, University College London, London, UK.; UCL School of Life and Medical Sciences, London, UK. |
| المصدر: | Journal of hematopathology [J Hematop] 2024 Jun; Vol. 17 (2), pp. 117-119. Date of Electronic Publication: 2024 Apr 06. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 101491976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-5785 (Electronic) Linking ISSN: 18655785 NLM ISO Abbreviation: J Hematop Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; Heidelberg : Springer |
| مواضيع طبية MeSH: | Leukemia, Plasma Cell*/pathology , Leukemia, Plasma Cell*/genetics , Leukemia, Plasma Cell*/diagnosis , Plasma Cells*/pathology, Humans ; Female ; Aged ; Multiple Myeloma/pathology ; Multiple Myeloma/diagnosis ; Mutation |
| مستخلص: | A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts. Target CD138-cell FISH and molecular karyotyping identified a complex genome. NGS identified high-risk mutations. Bone marrow histology confirmed myeloma with no evidence of acute leukaemia. The patient was diagnosed with plasmablastic progression of myeloma and secondary PCL. Secondary PCL patients have a poor prognosis. It is essential to recognize this subtype and explore a novel treatment approach. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| References: | de Larrea CF et al (2021) Primary plasma cell leukemia: consensus definition by the Internatinoal Myeloma Working Group according to peripheral blood plasma cell percentage. Blood Cancer J 11(12):192. Jurczyszyn A et al (2019) Secondary plasma cell leukemia: a multicenter retrospective study of 101 patients. Leuk Lymphoma 60(1):118–123. (PMID: 10.1080/10428194.2018.147357429965787) Greipp PR, Leong T, Bennett JM et al (1998) Plasmablastic morphology-an independent prognostic factor with clinical and laboratory correlates: Eastern Cooperative Oncology Group (ECOG) myeloma trial e9486 report by the ECOG myeloma laboratory group. Blood 91(7):2501–2507. https://doi.org/10.1182/blood.v91.7.2501. (PMID: 10.1182/blood.v91.7.25019516151) |
| فهرسة مساهمة: | Keywords: Multiple myeloma; Plasma cell leukaemia |
| تواريخ الأحداث: | Date Created: 20240405 Date Completed: 20240525 Latest Revision: 20240531 |
| رمز التحديث: | 20240601 |
| DOI: | 10.1007/s12308-024-00583-w |
| PMID: | 38580782 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1865-5785 |
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| DOI: | 10.1007/s12308-024-00583-w |