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Association and mediation analyses among multiple metal exposure, mineralocorticoid levels, and serum ion balance in residents of northwest China.

التفاصيل البيبلوغرافية
العنوان: Association and mediation analyses among multiple metal exposure, mineralocorticoid levels, and serum ion balance in residents of northwest China.
المؤلفون: Zhang H; The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China., Yan J; The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.; Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province, Lanzhou, 730000, Gansu, People's Republic of China., Nie G; The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China., Xie D; The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China., Zhu X; The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China., Niu J; School of Public Health, Institute of Occupational and Environmental Health, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China., Li X; The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China. lxdr21@126.com.; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China. lxdr21@126.com.; Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province, Lanzhou, 730000, Gansu, People's Republic of China. lxdr21@126.com.; Department of General Surgery, The First Hospital of Lanzhou University, No.1 Donggang West Road, Chengguan District, Lanzhou, 730030, Gansu, China. lxdr21@126.com.
المصدر: Scientific reports [Sci Rep] 2024 Apr 05; Vol. 14 (1), pp. 8023. Date of Electronic Publication: 2024 Apr 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Arsenic*/toxicity , Selenium* , Metals, Heavy*/toxicity, Humans ; Lead/toxicity ; Cadmium/toxicity ; Mediation Analysis ; Mineralocorticoids ; Heavy Metal Poisoning ; Zinc ; Iron ; Ions ; China
مستخلص: Toxic metals are vital risk factors affecting serum ion balance; however, the effect of their co-exposure on serum ions and the underlying mechanism remain unclear. We assessed the correlations of single metal and mixed metals with serum ion levels, and the mediating effects of mineralocorticoids by investigating toxic metal concentrations in the blood, as well as the levels of representative mineralocorticoids, such as deoxycorticosterone (DOC), and serum ions in 471 participants from the Dongdagou-Xinglong cohort. In the single-exposure model, sodium and chloride levels were positively correlated with arsenic, selenium, cadmium, and lead levels and negatively correlated with zinc levels, whereas potassium and iron levels and the anion gap were positively correlated with zinc levels and negatively correlated with selenium, cadmium and lead levels (all P < 0.05). Similar results were obtained in the mixed exposure models considering all metals, and the major contributions of cadmium, lead, arsenic, and selenium were highlighted. Significant dose-response relationships were detected between levels of serum DOC and toxic metals and serum ions. Mediation analysis showed that serum DOC partially mediated the relationship of metals (especially mixed metals) with serum iron and anion gap by 8.3% and 8.6%, respectively. These findings suggest that single and mixed metal exposure interferes with the homeostasis of serum mineralocorticoids, which is also related to altered serum ion levels. Furthermore, serum DOC may remarkably affect toxic metal-related serum ion disturbances, providing clues for further study of health risks associated with these toxic metals.
(© 2024. The Author(s).)
References: J Clin Endocrinol Metab. 2018 Feb 1;103(2):748-758. (PMID: 29077874)
Public Health Nutr. 2019 Jun;22(9):1635-1645. (PMID: 30894241)
Environ Res. 2021 Jun;197:111013. (PMID: 33716025)
Environ Res. 2022 Apr 15;206:112615. (PMID: 34968434)
Toxicol Res (Camb). 2018 Jan 29;7(3):396-407. (PMID: 30090589)
Chemosphere. 2022 Aug;300:134548. (PMID: 35413364)
Biol Trace Elem Res. 2022 Feb;200(2):560-567. (PMID: 33837913)
J Consult Clin Psychol. 1997 Aug;65(4):599-610. (PMID: 9256561)
Molecules. 2022 Apr 16;27(8):. (PMID: 35458775)
Endocrine. 2023 Mar;79(3):577-586. (PMID: 36350462)
Ecotoxicol Environ Saf. 2011 May;74(4):658-67. (PMID: 21035190)
Biol Trace Elem Res. 2016 Jun;171(2):459-467. (PMID: 26537118)
Environ Health Perspect. 2016 Jan;124(1):A6-9. (PMID: 26720830)
Arch Environ Occup Health. 2019;74(5):239-251. (PMID: 29677460)
Front Public Health. 2022 Aug 01;10:906774. (PMID: 35979456)
Plant Physiol Biochem. 2018 Jun;127:457-468. (PMID: 29689509)
Chemosphere. 2023 Mar;317:137854. (PMID: 36649900)
Chemosphere. 2022 Jan;287(Pt 3):132190. (PMID: 34826933)
Environ Sci Pollut Res Int. 2017 Dec;24(35):27303-27313. (PMID: 28967049)
Biol Trace Elem Res. 2017 May;177(1):180-186. (PMID: 27761845)
Biostatistics. 2015 Jul;16(3):493-508. (PMID: 25532525)
Biol Trace Elem Res. 2021 Dec;199(12):4504-4515. (PMID: 33483859)
Int J Environ Res Public Health. 2022 Apr 18;19(8):. (PMID: 35457774)
Physiol Behav. 2017 Sep 1;178:28-34. (PMID: 28267585)
Toxicol Mech Methods. 2020 Mar;30(3):167-176. (PMID: 31818169)
Chemosphere. 2015 Jun;128:70-8. (PMID: 25655821)
Sci Total Environ. 2022 Nov 25;849:157934. (PMID: 35952868)
Endocrine. 2016 Jul;53(1):240-8. (PMID: 26839091)
Adv Nutr. 2019 Nov 1;10(Suppl_4):S367-S379. (PMID: 31728497)
Curr Environ Health Rep. 2017 Dec;4(4):481-490. (PMID: 28988291)
Front Physiol. 2022 Feb 07;13:770375. (PMID: 35197862)
Chemosphere. 2022 Feb;289:133147. (PMID: 34864016)
Ann N Y Acad Sci. 2013 Oct;1301:21-6. (PMID: 24117725)
Environ Geochem Health. 2022 Nov;44(11):4173-4189. (PMID: 35037141)
Environ Int. 2021 Apr;149:106410. (PMID: 33548850)
Dig Dis Sci. 2017 Aug;62(8):1855-1871. (PMID: 28501971)
Environ Sci Pollut Res Int. 2020 Mar;27(7):7702-7711. (PMID: 31889282)
Toxicol In Vitro. 2010 Oct;24(7):1899-904. (PMID: 20667467)
Environ Health Perspect. 2020 Apr;128(4):47004. (PMID: 32255670)
Arch Toxicol. 1987 Feb;59(5):365-70. (PMID: 3579601)
Crit Rev Oncol Hematol. 2021 May;161:103330. (PMID: 33862246)
Environ Pollut. 2022 Sep 15;309:119780. (PMID: 35841990)
Hypertension. 2022 Sep;79(9):1899-1911. (PMID: 35766038)
Med Pr. 1995;46(3):239-46. (PMID: 7565072)
Environ Res. 2021 Apr;195:110749. (PMID: 33465343)
J Agric Biol Environ Stat. 2015 Mar;20(1):100-120. (PMID: 30505142)
Nat Rev Immunol. 2019 Aug;19(8):517-532. (PMID: 30992524)
Environ Pollut. 2023 Jan 15;317:120727. (PMID: 36427825)
Biol Trace Elem Res. 2012 Nov;149(2):143-7. (PMID: 22528781)
Ecotoxicol Environ Saf. 2019 Jan 30;168:146-163. (PMID: 30384162)
Biol Trace Elem Res. 2021 Nov;199(11):4218-4224. (PMID: 33403575)
Environ Sci Pollut Res Int. 2022 Sep;29(41):62067-62092. (PMID: 34558053)
Environ Sci Pollut Res Int. 2021 Dec;28(45):64253-64267. (PMID: 34302251)
Chemosphere. 2021 Jan;262:128350. (PMID: 33182141)
Pest Manag Sci. 2021 Mar;77(3):1115-1120. (PMID: 32965074)
Biol Trace Elem Res. 2022 Sep;200(9):3932-3940. (PMID: 34713392)
Environ Res. 2021 Oct;201:111558. (PMID: 34224706)
J Trace Elem Med Biol. 2018 Mar;46:150-155. (PMID: 29413105)
Open Access Maced J Med Sci. 2016 Jun 15;4(2):302-6. (PMID: 27335606)
Biol Trace Elem Res. 2021 Apr;199(4):1574-1583. (PMID: 32602051)
Clin Sci (Lond). 2019 Jan 8;133(1):75-82. (PMID: 30622159)
J Trace Elem Med Biol. 2023 Jan;75:127108. (PMID: 36435152)
J Hazard Mater. 2021 Oct 5;419:126497. (PMID: 34323735)
BMC Med. 2022 Jun 17;20(1):207. (PMID: 35710548)
Pharmacol Res. 2021 Oct;172:105835. (PMID: 34438065)
Eur Heart J. 2021 Jan 7;42(2):152-161. (PMID: 33099609)
Best Pract Res Clin Endocrinol Metab. 2018 Aug;32(4):397-424. (PMID: 30086866)
Environ Sci Pollut Res Int. 2023 Jan;30(4):10063-10078. (PMID: 36066802)
Diabetes Obes Metab. 2019 Mar;21(3):509-516. (PMID: 30225967)
Drug Chem Toxicol. 2020 Jan;43(1):37-42. (PMID: 31111748)
Chemosphere. 2023 Mar;317:137783. (PMID: 36638928)
Front Pharmacol. 2021 Apr 13;12:643972. (PMID: 33927623)
Am J Kidney Dis. 2015 Feb;65(2):240-8. (PMID: 25168294)
Environ Geochem Health. 2022 Oct;44(10):3215-3238. (PMID: 34455537)
Environ Health. 2018 Aug 20;17(1):67. (PMID: 30126431)
Chemosphere. 2019 Feb;216:352-364. (PMID: 30384304)
Environ Pollut. 2018 Nov;242(Pt A):12-18. (PMID: 29957541)
Environ Health Perspect. 2021 Mar;129(3):38001. (PMID: 33688746)
Environ Int. 2019 Dec;133(Pt A):105133. (PMID: 31520960)
Environ Sci Technol. 2017 May 16;51(10):5803-5810. (PMID: 28430429)
معلومات مُعتمدة: 32060289 National Natural Science Foundation of China; 32171610 National Natural Science Foundation of China; 81872578 National Natural Science Foundation of China; 20JR10RA699 Natural Science Foundation of Gansu Province
فهرسة مساهمة: Keywords: Deoxycorticosterone; Exposure–response relationship; Mediation analysis; Serum ions; Toxic metals
المشرفين على المادة: 2P299V784P (Lead)
N712M78A8G (Arsenic)
00BH33GNGH (Cadmium)
0 (Mineralocorticoids)
H6241UJ22B (Selenium)
J41CSQ7QDS (Zinc)
E1UOL152H7 (Iron)
0 (Ions)
0 (Metals, Heavy)
تواريخ الأحداث: Date Created: 20240405 Date Completed: 20240408 Latest Revision: 20240409
رمز التحديث: 20240409
مُعرف محوري في PubMed: PMC10997635
DOI: 10.1038/s41598-024-58607-5
PMID: 38580805
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-58607-5