دورية أكاديمية
أعرض في EDS

A study of hospitalized COVID-19 patients with AKI in a setting of multiracial developing country.

التفاصيل البيبلوغرافية
العنوان: A study of hospitalized COVID-19 patients with AKI in a setting of multiracial developing country.
المؤلفون: Ooi SH; Internal Medicine Department, University Malaya Medical Center, Kuala Lumpur, Malaysia., Ng KP; Internal Medicine Department, University Malaya Medical Center, Kuala Lumpur, Malaysia. kokpeng5@yahoo.com., Sthaneshwar P; Pathology Department, University of Malaya, Kuala Lumpur, Malaysia., Lim SK; Internal Medicine Department, University Malaya Medical Center, Kuala Lumpur, Malaysia., Khor PY; Internal Medicine Department, University Malaya Medical Center, Kuala Lumpur, Malaysia., Lim JY; Internal Medicine Department, University Malaya Medical Center, Kuala Lumpur, Malaysia., Siow WS; Internal Medicine Department, University Malaya Medical Center, Kuala Lumpur, Malaysia., Lim KW; Internal Medicine Department, University Malaya Medical Center, Kuala Lumpur, Malaysia., Azlan M; Internal Medicine Department, University Malaya Medical Center, Kuala Lumpur, Malaysia.
المصدر: BMC nephrology [BMC Nephrol] 2024 Apr 05; Vol. 25 (1), pp. 122. Date of Electronic Publication: 2024 Apr 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2000-
مواضيع طبية MeSH: COVID-19*/epidemiology , COVID-19*/therapy , COVID-19*/complications , Acute Kidney Injury*/epidemiology , Acute Kidney Injury*/therapy , Acute Kidney Injury*/diagnosis , Diabetes Mellitus* , Renal Insufficiency, Chronic*/epidemiology , Renal Insufficiency, Chronic*/complications , Hypertension*/complications, Humans ; Male ; Female ; Middle Aged ; Adolescent ; Retrospective Studies ; Developing Countries ; Risk Factors ; Hospital Mortality
مستخلص: Background: The commonest indication for hospitalization in COVID-19 patients is hypoxemia or severe respiratory symptoms. However, COVID-19 disease may result in extrapulmonary complications including kidney-related pathology. The reported incidence of renal involvement related to COVID infection varies based on geographical location.
Objective: This study aimed to assess the incidence rate of AKI in hospitalized COVID-19 patients and identify risk factors and prognostic predictors.
Method: In this retrospective study, we recruited hospitalized COVID-19 patients from January 2021 until June 2021 at the University Malaya Medical Center. The inclusion criteria were hospitalized for ≥ 48 h with confirmed COVID-19 infection and at least 18 years old. Patient demographic and clinical data were collected from electronic medical records. The staging of AKI was based on criteria as per KDIGO guidelines.
Results: One thousand five hundred twenty-nine COVID patients fulfilled the inclusion criteria with a male-to-female ratio of 759 (49.6%) to 770 (50.3%). The median age was 55 (IQR: 36-66). 500 patients (32.7%) had diabetes, 621 (40.6%) had hypertension, and 5.6% (n = 85) had pre-existing chronic kidney disease (CKD). The incidence rate of AKI was 21.1% (n = 323). The percentage of COVID patients in different AKI stages of 1,2 and 3 were 16.3%, 2.1%, and 2.7%, respectively. Fifteen hospitalized patients (0.98%) required renal replacement therapy. 58.8% (n = 190) of AKI group had complete recovery of kidney function. Demographic factors included age (p < 0.001), diabetes (p < 0.001), hypertension (p < 0.012), CKD (p < 0.001), and vaccination status (p = 0.042) were associated with an increased risk of developing AKI. We found that the AKI cohort had statistically significant lower platelet counts and higher ferritin levels than the non-AKI cohort. AKI is a risk predictor of prolonged hospitalization (p < 0.001) and higher mortality rates (P < 0.001).
Conclusion: AKI is a common clinical complication among hospitalized COVID-19 patients. The etiology of AKI is multifactorial and may have an adverse impact on patient morbidity and mortality.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Acute kidney injury; Covid-19; Multiracial developing country
تواريخ الأحداث: Date Created: 20240405 Date Completed: 20240408 Latest Revision: 20240408
رمز التحديث: 20240408
مُعرف محوري في PubMed: PMC10998399
DOI: 10.1186/s12882-024-03498-x
PMID: 38580977
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2369
DOI:10.1186/s12882-024-03498-x