دورية أكاديمية
أعرض في EDS

Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients.

التفاصيل البيبلوغرافية
العنوان: Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients.
المؤلفون: Nørregaard LB; The Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Wickham KA; The Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.; Environmental Ergonomics Lab, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON, Canada., Jeppesen JS; The Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Rytter N; The Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Christoffersen LC; The Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Gliemann L; The Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Lawrence M; Welsh Centre for Emergency Medicine Research, Morriston Hospital, Swansea Bay University Health Board, Swansea, UK., Evans PA; Welsh Centre for Emergency Medicine Research, Morriston Hospital, Swansea Bay University Health Board, Swansea, UK.; Swansea University Medical School, Swansea, UK., Kruuse C; Neurovascular Research Unit, Department of Neurology, Herlev Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Hellsten Y; The Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. yhellsten@nexs.ku.dk.
المصدر: Thrombosis journal [Thromb J] 2024 Apr 05; Vol. 22 (1), pp. 35. Date of Electronic Publication: 2024 Apr 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101170542 Publication Model: Electronic Cited Medium: Print ISSN: 1477-9560 (Print) Linking ISSN: 14779560 NLM ISO Abbreviation: Thromb J Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2003-
مستخلص: Introduction: Older individuals and, in particular, individuals at risk of recurrent stroke, may be susceptible to thrombosis when participating in exercise, however, this aspect has not been well investigated.
Methods: Clot microstructure and conventional markers of thrombotic risk were determined in twenty lacunar stroke patients and fifteen healthy age-matched controls before, immediately after and 1 h after a bout of moderate intensity cycling exercise. Data were analyzed using a linear mixed model approach.
Results: At rest, clot microstructure (1.69 ± 0.07 vs. 1.64 ± 0.05, corresponding to a difference of ~ 50% in normalized clot mass; p = 0.009) and thrombocyte count (73%; p < 0.0001) were higher, and activated partial thromboplastin time was lower (18%; p = 0.0001) in stroke patients compared to age-matched controls. Acute exercise increased thrombogenic markers similarly in the two groups: incipient clot microstructure (1.69 ± 0.07 vs. 1.74 ± 0.05; p = 0.0004 and 1.64 ± 0.05 vs. 1.71 ± 0.04; p < 0.0001, for stroke and controls respectively), plasma fibrinogen (12%; p < 0.0001 and 18%; p < 0.0001, for stroke and controls respectively) and the combined coagulation factors II, VII and X (p = 0.0001 and p < 0.0001, for stroke and controls respectively).
Conclusion: The results show that exercise transiently increases the risk of blood clot formation in both stroke patients and controls, however, due to the higher baseline thrombogenicity in stroke patients, the post exercise risk of forming blood clots may be higher in this group.
Trial Registration: Registered at ClinicalTrials.gov (NCT03635177).
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Clot microstructure; Coagulation; Exercise; Lacunar stroke patients; Thrombogenicity
سلسلة جزيئية: ClinicalTrials.gov NCT03635177
تواريخ الأحداث: Date Created: 20240405 Latest Revision: 20240408
رمز التحديث: 20240408
مُعرف محوري في PubMed: PMC10996168
DOI: 10.1186/s12959-024-00604-9
PMID: 38581046
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-9560
DOI:10.1186/s12959-024-00604-9