دورية أكاديمية
P2X 7 receptor-dependent increase in endocannabinoid 2-arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism.
| العنوان: | P2X |
|---|---|
| المؤلفون: | Singh S; Department of Pharmacology, University of Washington, Seattle, Washington, USA., Sarroza D; Department of Pharmacology, University of Washington, Seattle, Washington, USA., English A; Department of Pharmacology, University of Washington, Seattle, Washington, USA., Whittington D; Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA., Dong A; Peking University School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China., Malamas M; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, USA., Makriyannis A; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, USA., van der Stelt M; Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands., Li Y; Peking University School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China., Zweifel L; Department of Pharmacology, University of Washington, Seattle, Washington, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.; Center for Cannabis Research, University of Washington, Seattle, Washington, USA.; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, Washington, USA., Bruchas MR; Department of Pharmacology, University of Washington, Seattle, Washington, USA.; Center for Cannabis Research, University of Washington, Seattle, Washington, USA.; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, Washington, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USA., Land BB; Department of Pharmacology, University of Washington, Seattle, Washington, USA.; Center for Cannabis Research, University of Washington, Seattle, Washington, USA.; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, Washington, USA., Stella N; Department of Pharmacology, University of Washington, Seattle, Washington, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.; Center for Cannabis Research, University of Washington, Seattle, Washington, USA.; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, Washington, USA. |
| المصدر: | British journal of pharmacology [Br J Pharmacol] 2024 Aug; Vol. 181 (15), pp. 2459-2477. Date of Electronic Publication: 2024 Apr 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Wiley Original Publication: London, Macmillian Journals Ltd. |
| مواضيع طبية MeSH: | Endocannabinoids*/metabolism , Glycerides*/metabolism , Arachidonic Acids*/metabolism , Receptors, Purinergic P2X7*/metabolism , Neurons*/metabolism , Neurons*/drug effects, Animals ; Mice ; Adenosine Triphosphate/metabolism ; Monoacylglycerol Lipases/metabolism ; Monoacylglycerol Lipases/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/metabolism ; Polyunsaturated Alkamides/metabolism ; Cell Line, Tumor |
| مستخلص: | Background and Purpose: Neurotransmission and neuroinflammation are controlled by local increases in both extracellular ATP and the endocannabinoid 2-arachidonoyl glycerol (2-AG). While it is known that extracellular ATP stimulates 2-AG production in cells in culture, the dynamics and molecular mechanisms that underlie this response remain poorly understood. Detection of real-time changes in eCB levels with the genetically encoded sensor, GRAB Experimental Approach: 2-AG and arachidonoylethanolamide (AEA) levels in Neuro2a (N2a) cells were measured by LC-MS, and GRAB Key Results: 2-AG and AEA increased GRAB Conclusions and Implications: Considering that P2X (© 2024 British Pharmacological Society.) |
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| معلومات مُعتمدة: | DA033396 United States NH NIH HHS; DA047626 United States NH NIH HHS; DA055448 United States NH NIH HHS; NS118130 United States NH NIH HHS; T32GM007750 United States NH NIH HHS; 81821092 Science Fund for Creative Research Groups of the National Natural Science Foundation of China; NYKFKT2019013 Shenzhen-Hong Kong Institute of Brain Science; Z181100001318002 Beijing Municipal Science & Technology Commission; Z181100001518004 Beijing Municipal Science & Technology Commission; 31871087 National Natural Science Foundation of China; 31925017 National Natural Science Foundation of China; DA033396 United States NH NIH HHS; DA047626 United States NH NIH HHS; DA055448 United States NH NIH HHS; NS118130 United States NH NIH HHS; T32GM007750 United States NH NIH HHS; P30DA048736 University of Washington Center of Excellence in Opioid Addiction Research/Molecular Genetics Resource Core; 1U01NS113358 NIH BRAIN Initiative; Peking-Tsinghua Center for Life Sciences; State Key Laboratory of Membrane Biology at Peking University School of Life Sciences |
| فهرسة مساهمة: | Keywords: 2‐AG; ATP; endocannabinoids; genetically encoded sensor; purinergic receptors |
| المشرفين على المادة: | 0 (Endocannabinoids) 0 (Glycerides) 8D239QDW64 (glyceryl 2-arachidonate) 0 (Arachidonic Acids) 0 (Receptors, Purinergic P2X7) 8L70Q75FXE (Adenosine Triphosphate) EC 3.1.1.23 (Monoacylglycerol Lipases) EC 3.1.1.23 (ABHD6 protein, mouse) 0 (Receptor, Cannabinoid, CB1) UR5G69TJKH (anandamide) 0 (Polyunsaturated Alkamides) |
| تواريخ الأحداث: | Date Created: 20240406 Date Completed: 20240702 Latest Revision: 20240726 |
| رمز التحديث: | 20240726 |
| DOI: | 10.1111/bph.16348 |
| PMID: | 38581262 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1476-5381 |
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| DOI: | 10.1111/bph.16348 |