دورية أكاديمية
Efficacy analysis of clinical serological indicators in the diagnosis of postoperative periprosthetic joint infection in patients with rheumatoid arthritis or osteoarthritis.
| العنوان: | Efficacy analysis of clinical serological indicators in the diagnosis of postoperative periprosthetic joint infection in patients with rheumatoid arthritis or osteoarthritis. |
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| المؤلفون: | Zhao H; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266071, China., Li L; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266071, China., Wang HY; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266071, China., Ding L; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266071, China., Wang Y; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266071, China., Liu X; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266071, China., Tian S; Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266071, China. shaoqi99@aliyun.com., Wang Y; Department of Gynecology, The Women and Children's Hospital of Qingdao, Tongfu Road 6, Qingdao, 266034, China. shandongm@163.com. |
| المصدر: | International orthopaedics [Int Orthop] 2024 Aug; Vol. 48 (8), pp. 1945-1952. Date of Electronic Publication: 2024 Apr 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7705431 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5195 (Electronic) Linking ISSN: 03412695 NLM ISO Abbreviation: Int Orthop Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer Verlag |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid*/surgery , Arthritis, Rheumatoid*/complications , Arthritis, Rheumatoid*/blood , Prosthesis-Related Infections*/diagnosis , Prosthesis-Related Infections*/etiology , Prosthesis-Related Infections*/blood , Prosthesis-Related Infections*/epidemiology , Blood Sedimentation* , C-Reactive Protein*/analysis , Fibrin Fibrinogen Degradation Products*/analysis , Biomarkers*/blood, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Osteoarthritis/surgery ; Osteoarthritis/diagnosis ; Osteoarthritis/blood ; Arthroplasty, Replacement, Knee/adverse effects ; Incidence ; Arthroplasty, Replacement, Hip/adverse effects ; Adult |
| مستخلص: | Purpose: To investigate the incidence of periprosthetic joint infection (PJI) in patients with rheumatoid arthritis (RA) or osteoarthritis (OA) after primary joint arthroplasty; to analyze the optimal cut-off values of clinical serum markers C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and D-dimer for the diagnosis of PJI in RA patients; and to explore their diagnostic efficacy and clinical significance. Methods: Clinical data of 15,702 patients with RA (578) or OA (15,124) who underwent total joint arthroplasty from 2013 to 2021 were retrospectively analyzed. Serum CRP, ESR, and D-dimer were recorded for each patient, and subject characteristic curves were used to determine the optimal threshold values of CRP, ESR, and D-dimer for RA-PJI and OA-PJI and to compare the areas under the curves to assess the diagnostic efficacy of the optimal threshold values of serologic indices for RA-PJI. Results: The five year incidence of PJI was 6.92% in RA patients and 0.67% in OA patients. The optimal thresholds of CRP, ESR, and D-dimer for the diagnosis of RA-PJI were respectively 13.85 mg/L, 33.02 mm/h, and 796.50 ng/mL. The sensitivities of the optimal thresholds were respectively 67.6%, 62.2%, and 56.8%, and the specificities were 74.7%, 60.4%, and 74.4%. Conclusion: RA patients have a higher incidence of PJI than OA patients. The optimal thresholds for CRP, ESR, and d-dimer for the diagnosis of PJI were higher in RA patients than in OA patients, but the sensitivity and specificity of the diagnosis were not as good as in OA patients. (© 2024. The Author(s) under exclusive licence to SICOT aisbl.) |
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| فهرسة مساهمة: | Keywords: CRP; D-dimer; ESR; Osteoarthritis; Periprosthetic joint infection; Rheumatoid arthritis |
| المشرفين على المادة: | 9007-41-4 (C-Reactive Protein) 0 (fibrin fragment D) 0 (Fibrin Fibrinogen Degradation Products) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240406 Date Completed: 20240713 Latest Revision: 20240903 |
| رمز التحديث: | 20240903 |
| DOI: | 10.1007/s00264-024-06171-y |
| PMID: | 38581467 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-5195 |
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| DOI: | 10.1007/s00264-024-06171-y |