دورية أكاديمية
Exposure to urban ambient particles (PM2.5) before pregnancy affects the expression of endometrial receptive markers to embryo implantation in mice: Preliminary results.
| العنوان: | Exposure to urban ambient particles (PM2.5) before pregnancy affects the expression of endometrial receptive markers to embryo implantation in mice: Preliminary results. |
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| المؤلفون: | de Castro KR; Laboratory of Experimental Air Pollution (LIM05), Department of Pathology, School of Medicine, University of São Paulo, São Paulo, São Paulo State, Brazil., Almeida GHDR; Department of Surgery, Faculty of the Veterinary Medicine and Animal Science, University of São Paulo, São Paulo State, Brazil., Matsuda M; Division of Ophthalmology and Laboratory of Investigation in Ophthalmology (LIM33), School of Medicine, University of São Paulo, São Paulo State, Brazil., de Paula Vieira R; Human Movement and Rehabilitation Post-Graduation Program, Evangelical University of Goiás -UniEVANGÉLICA, Anápolis, GO, Brazil., Martins MG; Laboratory of Experimental Air Pollution (LIM05), Department of Pathology, School of Medicine, University of São Paulo, São Paulo, São Paulo State, Brazil., Rici REG; Department of Surgery, Faculty of the Veterinary Medicine and Animal Science, University of São Paulo, São Paulo State, Brazil; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia, São Paulo, Brazil., Saldiva PHN; Laboratory of Experimental Air Pollution (LIM05), Department of Pathology, School of Medicine, University of São Paulo, São Paulo, São Paulo State, Brazil., Veras MM; Laboratory of Experimental Air Pollution (LIM05), Department of Pathology, School of Medicine, University of São Paulo, São Paulo, São Paulo State, Brazil. Electronic address: verasine@usp.br. |
| المصدر: | Tissue & cell [Tissue Cell] 2024 Jun; Vol. 88, pp. 102368. Date of Electronic Publication: 2024 Mar 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Edinburgh : Churchill Livingstone Original Publication: Edinburgh, Oliver & Boyd. |
| مواضيع طبية MeSH: | Embryo Implantation*/drug effects , Endometrium*/metabolism , Endometrium*/drug effects , Particulate Matter*, Animals ; Female ; Pregnancy ; Mice ; Biomarkers/metabolism ; Male ; Leukemia Inhibitory Factor/metabolism |
| مستخلص: | Air pollution (AP) is one of the main recent concerns in reproductive healthy due to its potential to promote negative outcomes during pregnancy and male and female fertility. Several studies have demonstrated that AP exposure has been linked to increased embryonic implantation failures, alterations in embryonic, fetal and placental development. For a well-succeeded implantation, both competent blastocyst and receptive endometrium are required. Based on the lack of data about the effect of AP in endometrial receptivity, this study aimed to evaluate he particulate matter (PM) exposure impact on uterine receptive markers in mice and associate the alterations to increased implantation failures due to AP. For this study, ten dams per group were exposed for 39 days to either filter (F) or polluted air (CAP). At fourth gestational day (GD4), females were euthanized. Morphological, ultrastructural, immunohistochemical and molecular analysis of uterine and ovarian samples were performed. CAP-exposed females presented a reduced number of corpus luteum; glands and epithelial cells were increased with pinopodes formation impairment. Immunohistochemistry analysis revealed decreased LIF protein levels. These preliminary data suggests that PM exposure may exert negative effects on endometrial receptivity by affecting crucial parameters to embryonic implantation as uterine morphological differentiation, corpus luteum quantity and LIF expression during implantation window. Competing Interests: Declaration of Competing Interest The authors declare that there are no conflicts of interest associated with this study. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Air pollution; Cytokines; Embryonic implantation; Endometrial receptivity; Pinopodes |
| المشرفين على المادة: | 0 (Particulate Matter) 0 (Biomarkers) 0 (Leukemia Inhibitory Factor) |
| تواريخ الأحداث: | Date Created: 20240407 Date Completed: 20240615 Latest Revision: 20240615 |
| رمز التحديث: | 20240616 |
| DOI: | 10.1016/j.tice.2024.102368 |
| PMID: | 38583225 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-3072 |
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| DOI: | 10.1016/j.tice.2024.102368 |