دورية أكاديمية
Central versus peripheral thickness in the human cornea explained.
| العنوان: | Central versus peripheral thickness in the human cornea explained. |
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| المؤلفون: | Bergmanson JPG; University of Houston, College of Optometry, Texas Eye Research & Technology Center, 4401 Martin Luther King Boulevard, Houston, TX 77204-2020, United States. Electronic address: jbergmanson@central.uh.edu., Burns AR; University of Houston, College of Optometry, Texas Eye Research & Technology Center, 4401 Martin Luther King Boulevard, Houston, TX 77204-2020, United States., Walker MK; University of Houston, College of Optometry, Texas Eye Research & Technology Center, 4401 Martin Luther King Boulevard, Houston, TX 77204-2020, United States. |
| المصدر: | Contact lens & anterior eye : the journal of the British Contact Lens Association [Cont Lens Anterior Eye] 2024 Jun; Vol. 47 (3), pp. 102165. Date of Electronic Publication: 2024 Apr 07. |
| نوع المنشور: | Journal Article; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9712714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5411 (Electronic) Linking ISSN: 13670484 NLM ISO Abbreviation: Cont Lens Anterior Eye Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Oxford : Elsevier Original Publication: Houndmills, Basingstoke, UK : Stockton Press, c1997- |
| مواضيع طبية MeSH: | Corneal Stroma*/ultrastructure , Corneal Stroma*/diagnostic imaging , Cornea*/ultrastructure, Humans ; Tissue Donors ; Middle Aged ; Male ; Corneal Pachymetry ; Microscopy, Electron, Transmission ; Female ; Adult ; Aged ; Collagen/metabolism ; Collagen/ultrastructure |
| مستخلص: | Purpose: The human cornea is thicker in the periphery than the center and it has been suggested that this must be due to greater numbers of lamellae in the peripheral corneal stroma. The purpose of this study was to use high-resolution ultrastructural imaging to determine if the greater thickness of the peripheral cornea is due to the presence of more lamellae or if there is some other anatomical explanation. Methods: In this study, full thickness corneas from three human donors were processed for light microscopy (LM) and transmission electron microscopy (TEM). Images were taken in three distinct stromal regions (anterior, middle, and posterior) from the central and peripheral cornea. Stromal thickness was evaluated by LM while TEM was used to evaluate numbers and thicknesses of lamellae, mean collagen fibril diameter, and mean collagen fibril density. Results: Mean stromal thickness was significantly thinner in the central (415 ± 34 µm) compared to the peripheral (536 ± 29 µm) cornea (P = 0.009). Numbers of lamellae were not significantly different between central (246 ± 14) and peripheral (251 ± 14) cornea. Average lamellar thickness was not different across all regions of the cornea, except for the peripheral posterior where the lamellae were approximately 50 % thicker (P < 0.05). Collagen fibril diameters were larger in the peripheral cornea by approximately 30 % when compared to the central cornea, in all regions (P < 0.01). Conclusions: This study shows that it is an increase peripheral posterior lamellar thickness, rather than an increase in the number of lamellae, that accounts for the increase in corneal stromal thickness in the periphery of the human cornea. While collagen fibril diameters are greater throughout the peripheral stroma, the lamellae in the mid and anterior peripheral stroma are not thicker than centrally. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Collagen fibrils; Corneal stroma; Corneal thickness; Lamellae; Ultrastructure |
| تواريخ الأحداث: | Date Created: 20240408 Date Completed: 20240518 Latest Revision: 20240518 |
| رمز التحديث: | 20240519 |
| DOI: | 10.1016/j.clae.2024.102165 |
| PMID: | 38589268 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1476-5411 |
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| DOI: | 10.1016/j.clae.2024.102165 |