دورية أكاديمية
A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility.
| العنوان: | A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility. |
|---|---|
| المؤلفون: | Morgan PK; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Melbourne, Victoria, Australia., Pernes G; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Department of Immunology, Monash University, Melbourne, Victoria, Australia., Huynh K; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia., Giles C; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia., Paul S; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Smith AAT; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Mellett NA; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Liang A; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., van Buuren-Milne T; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Veiga CB; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Collins TJC; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Department of Immunology, Monash University, Melbourne, Victoria, Australia., Xu Y; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia., Lee MKS; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia., De Silva TM; Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, Victoria, Australia., Meikle PJ; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia., Lancaster GI; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. Graeme.lancaster@baker.edu.au.; Department of Immunology, Monash University, Melbourne, Victoria, Australia. Graeme.lancaster@baker.edu.au.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia. Graeme.lancaster@baker.edu.au., Murphy AJ; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. Andrew.murphy@baker.edu.au.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Melbourne, Victoria, Australia. Andrew.murphy@baker.edu.au.; Department of Immunology, Monash University, Melbourne, Victoria, Australia. Andrew.murphy@baker.edu.au.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia. Andrew.murphy@baker.edu.au. |
| المصدر: | Nature cell biology [Nat Cell Biol] 2024 Apr; Vol. 26 (4), pp. 645-659. Date of Electronic Publication: 2024 Apr 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Macmillan Magazines Ltd., [1999- |
| مواضيع طبية MeSH: | Ferroptosis*, Humans ; Animals ; Mice ; Fatty Acids, Unsaturated |
| مستخلص: | The cellular lipidome comprises thousands of unique lipid species. Here, using mass spectrometry-based targeted lipidomics, we characterize the lipid landscape of human and mouse immune cells ( www.cellularlipidatlas.com ). Using this resource, we show that immune cells have unique lipidomic signatures and that processes such as activation, maturation and development impact immune cell lipid composition. To demonstrate the potential of this resource to provide insights into immune cell biology, we determine how a cell-specific lipid trait-differences in the abundance of polyunsaturated fatty acid-containing glycerophospholipids (PUFA-PLs)-influences immune cell biology. First, we show that differences in PUFA-PL content underpin the differential susceptibility of immune cells to ferroptosis. Second, we show that low PUFA-PL content promotes resistance to ferroptosis in activated neutrophils. In summary, we show that the lipid landscape is a defining feature of immune cell identity and that cell-specific lipid phenotypes underpin aspects of immune cell physiology. (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.) |
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| معلومات مُعتمدة: | GNT1189012 Department of Health | National Health and Medical Research Council (NHMRC); GNT1197190 Department of Health | National Health and Medical Research Council (NHMRC); GNT2009965 Department of Health | National Health and Medical Research Council (NHMRC); GNT1194329 Department of Health | National Health and Medical Research Council (NHMRC); Operational support program State Government of Victoria (Victorian Government) |
| المشرفين على المادة: | 0 (Fatty Acids, Unsaturated) |
| تواريخ الأحداث: | Date Created: 20240408 Date Completed: 20240418 Latest Revision: 20240419 |
| رمز التحديث: | 20240420 |
| DOI: | 10.1038/s41556-024-01377-z |
| PMID: | 38589531 |
| قاعدة البيانات: | MEDLINE |
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