دورية أكاديمية
Determination of calcium, iron, and selenium in human serum by isotope dilution analysis using nitrogen microwave inductively coupled atmospheric pressure plasma mass spectrometry (MICAP-MS).
| العنوان: | Determination of calcium, iron, and selenium in human serum by isotope dilution analysis using nitrogen microwave inductively coupled atmospheric pressure plasma mass spectrometry (MICAP-MS). |
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| المؤلفون: | You Z; Bundesanstalt für Materialforschung und -Prüfung (BAM), Department 1 Analytical Chemistry; Reference Materials, Richard-Willstätter-Straße 11, 12489, Berlin, Germany. Zengchao.You@bam.de., Winckelmann A; Bundesanstalt für Materialforschung und -Prüfung (BAM), Department 1 Analytical Chemistry; Reference Materials, Richard-Willstätter-Straße 11, 12489, Berlin, Germany.; Humboldt-Universität Zu Berlin, Department of Chemistry, Brook-Taylor-Straße 2, 12489, Berlin, Germany., Vogl J; Bundesanstalt für Materialforschung und -Prüfung (BAM), Department 1 Analytical Chemistry; Reference Materials, Richard-Willstätter-Straße 11, 12489, Berlin, Germany., Recknagel S; Bundesanstalt für Materialforschung und -Prüfung (BAM), Department 1 Analytical Chemistry; Reference Materials, Richard-Willstätter-Straße 11, 12489, Berlin, Germany., Abad C; Bundesanstalt für Materialforschung und -Prüfung (BAM), Department 1 Analytical Chemistry; Reference Materials, Richard-Willstätter-Straße 11, 12489, Berlin, Germany. Carlos.Abad@bam.de. |
| المصدر: | Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2024 May; Vol. 416 (13), pp. 3117-3125. Date of Electronic Publication: 2024 Apr 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Heidelberg : Springer-Verlag, 2002- |
| مواضيع طبية MeSH: | Iron*/blood , Calcium*/blood , Mass Spectrometry*/methods , Selenium*/blood , Microwaves* , Nitrogen* , Atmospheric Pressure*, Humans ; Indicator Dilution Techniques |
| مستخلص: | In this study, we demonstrate the applicability of nitrogen microwave inductively coupled atmospheric pressure mass spectrometry (MICAP-MS) for Ca, Fe, and Se quantification in human serum using isotope dilution (ID) analysis. The matrix tolerance of MICAP-MS in Na matrix was investigated, revealing that high Na levels can suppress the signal intensity. This suppression is likely due to the plasma loading and the space charge effect. Moreover, 40 Ca and 44 Ca isotopic fractionation was noted at elevated Na concentration. Nine certified serum samples were analyzed using both external calibration and ID analysis. Overestimation of Cr, Zn, As, and Se was found in the results of external calibration, which might result from C-induced polyatomic interference and signal enhancement, respectively. Further investigations performed with methanol showed a similar enhancement effect for Zn, As, and Se, potentially supporting this assumption. The mass concentrations determined with ID analysis show metrological compatibility with the reference values, indicating that MICAP-MS combined with ID analysis can be a promising method for precise Ca, Fe, and Se determination. Moreover, this combination reduces the influence of matrix effects, broadening the applicability of MICAP-MS for samples with complex matrixes. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | Project number: 1075-01 1.6-161-Haushaltfinanziert Bundesanstalt für Materialforschung und -Prüfung |
| فهرسة مساهمة: | Keywords: Calcium; Human serum; Iron; Isotope dilution; Nitrogen microwave inductively coupled atmospheric pressure mass spectrometry; Selenium |
| المشرفين على المادة: | E1UOL152H7 (Iron) SY7Q814VUP (Calcium) H6241UJ22B (Selenium) N762921K75 (Nitrogen) |
| تواريخ الأحداث: | Date Created: 20240408 Date Completed: 20240503 Latest Revision: 20240506 |
| رمز التحديث: | 20240506 |
| مُعرف محوري في PubMed: | PMC11068692 |
| DOI: | 10.1007/s00216-024-05274-0 |
| PMID: | 38589614 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1618-2650 |
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| DOI: | 10.1007/s00216-024-05274-0 |