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Enantiopure Corral[4]BINOLs as Ultrastrong Receptors for Recognition and Differential Sensing of Steroids.

التفاصيل البيبلوغرافية
العنوان: Enantiopure Corral[4]BINOLs as Ultrastrong Receptors for Recognition and Differential Sensing of Steroids.
المؤلفون: Fu R; College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China., Li DY; College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, China., Tian JH; College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, China., Lin YL; College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, China., Zhao QY; College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China., Li WL; College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China., Chen FY; College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, China., Guo DS; College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, China., Cai K; College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Jun 10; Vol. 63 (24), pp. e202406233. Date of Electronic Publication: 2024 May 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004-> : Weinheim : Wiley-VCH
Original Publication: Weinheim/Bergstr. : New York, : Verlag Chemie ; Academic Press, c1962-
مواضيع طبية MeSH: Steroids*/chemistry , Steroids*/analysis , Naphthols*/chemistry, Stereoisomerism ; Molecular Structure
مستخلص: The precise recognition and sensing of steroids, a type of vital biomolecules, hold immense practical value across various domains. In this study, we introduced corral[4]BINOLs (C[4]BINOLs), a pair of enantiomeric conjugated deep-cavity hosts, as novel synthetic receptors for binding steroids. Due to the strong hydrophobic effect of their deep nonpolar, chiral cavities, the two enantiomers of C[4]BINOLs demonstrated exceptionally high recognition affinities (up to 10 12  M -1 ) for 16 important steroidal compounds as well as good enantioselectiviy (up to 15.5) in aqueous solutions, establishing them as the most potent known steroid receptors. Harnessing their ultrahigh affinity, remarkable enantioselectivity, and fluorescence emission properties, the two C[4]BINOL enantiomers were employed to compose a fluorescent sensor array which achieved discrimination and sensing of 16 structurally similar steroids at low concentrations.
(© 2024 Wiley-VCH GmbH.)
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معلومات مُعتمدة: 22271164 National Natural Science Foundation of China; U20A20259 National Natural Science Foundation of China; NCC2020FH04 Fundamental Research Funds for the Central Universities
فهرسة مساهمة: Keywords: Chiral macrocycles; fluorescent sensor array; molecular recognition; steroid receptors
المشرفين على المادة: 0 (Steroids)
0 (Naphthols)
تواريخ الأحداث: Date Created: 20240409 Date Completed: 20240603 Latest Revision: 20240730
رمز التحديث: 20240731
DOI: 10.1002/anie.202406233
PMID: 38591161
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-3773
DOI:10.1002/anie.202406233