Transposons Carrying the aacC2e Aminoglycoside and bla TEM Beta-Lactam Resistance Genes in Acinetobacter .

التفاصيل البيبلوغرافية
العنوان:	Transposons Carrying the aacC2e Aminoglycoside and bla TEM Beta-Lactam Resistance Genes in Acinetobacter .
المؤلفون:	Tobin LA; Australian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, Australia., Cain AK; ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, Australia., Djordjevic SP; Australian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, Australia., Hamidian M; Australian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, Australia.
المصدر:	Microbial drug resistance (Larchmont, N.Y.) [Microb Drug Resist] 2024 Jun; Vol. 30 (6), pp. 273-278. Date of Electronic Publication: 2024 Apr 08.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 9508567 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-8448 (Electronic) Linking ISSN: 10766294 NLM ISO Abbreviation: Microb Drug Resist Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Larchmont, N.Y. : Mary Ann Liebert, c1995-
مواضيع طبية MeSH:	DNA Transposable Elements/genetics , Anti-Bacterial Agents/pharmacology , Aminoglycosides/pharmacology , Plasmids/genetics , Acinetobacter baumannii/genetics , Acinetobacter baumannii/drug effects, beta-Lactamases/genetics ; Acinetobacter/genetics ; Acinetobacter/drug effects ; Microbial Sensitivity Tests ; beta-Lactam Resistance/genetics ; beta-Lactams/pharmacology ; Drug Resistance, Multiple, Bacterial/genetics ; Bacterial Proteins/genetics
مستخلص:	This study examines the genetic contexts and evolutionary steps responsible for the formation of the widely spread transposon Tn 6925 carrying bla TEM and aacC2e, which confers resistance to beta-lactam and aminoglycoside antibiotics in Gram-negative bacteria. The bla TEM-1 and aacC2e genes were found in several transposons. They were first observed within an IS 26 bounded 3.7 kb transposon (Tn 6925) on several Acinetobacter baumannii plasmids located within a 4.7 kb dif module. Truncated and expanded variations of Tn 6925 were found across other A. baumannii plasmids, as well as in other Gram-negative bacteria (including Vibrio cholerae ). Moreover, bla TEM-1 and aacC2e were in much larger resistance-heavy transposons including the ISAba1-bounded 24.6 kb (here called Tn 6927 ), found in an A. baumannii chromosome. A novel ISKpn12-bounded transposon was also observed to contain bla TEM and aacC2e which was found interrupting Tn 5393 along with an IS 26 pseudo-compound transposon to form a 24.9 kb resistance island in an Acinetobacter pittii plasmid. Multiple mobile genetic elements are involved in the formation of transposon structures that circulate bla TEM and aacC2e . Among these, IS 26 and ISAba1 appear to have played a major role in the formation and spread of these elements in the Acinetobacter species.
فهرسة مساهمة:	Keywords: Acinetobacter baumannii; aacC2e; blaTEM, and antibiotic resistance; plasmid; transposon
المشرفين على المادة:	0 (DNA Transposable Elements) 0 (Anti-Bacterial Agents) 0 (Aminoglycosides) EC 3.5.2.6 (beta-Lactamases) 0 (beta-Lactams) 0 (Bacterial Proteins)
تواريخ الأحداث:	Date Created: 20240409 Date Completed: 20240626 Latest Revision: 20240626
رمز التحديث:	20240626
DOI:	10.1089/mdr.2023.0299
PMID:	38593463
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1931-8448
DOI:	10.1089/mdr.2023.0299