دورية أكاديمية
أعرض في EDS

ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin.

التفاصيل البيبلوغرافية
العنوان: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin.
المؤلفون: Cacho-Navas C; Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain., López-Pujante C; Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain., Reglero-Real N; William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Colás-Algora N; Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain., Cuervo A; Centro Nacional de Biotecnologia (CSIC), Madrid, Spain., Conesa JJ; Centro Nacional de Biotecnologia (CSIC), Madrid, Spain., Barroso S; Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain., de Rivas G; Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain., Ciordia S; Centro Nacional de Biotecnologia (CSIC), Madrid, Spain., Paradela A; Centro Nacional de Biotecnologia (CSIC), Madrid, Spain., D'Agostino G; Centro Nacional de Biotecnologia (CSIC), Madrid, Spain., Manzo C; Facultat de Ciències, Tecnologia i Enginyeries, Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain., Feito J; Servicio de Anatomía Patológica, Hospital Universitario de Salamanca, Salamanca, Spain., Andrés G; Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain., Molina-Jiménez F; Molecular Biology Unit, Hospital Universitario de la Princesa, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa), Madrid, Spain., Majano P; Molecular Biology Unit, Hospital Universitario de la Princesa, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.; Department of Cellular Biology, Universidad Complutense de Madrid, Madrid, Spain., Correas I; Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain., Carazo JM; Centro Nacional de Biotecnologia (CSIC), Madrid, Spain., Nourshargh S; William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Huch M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Millán J; Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
المصدر: ELife [Elife] 2024 Apr 10; Vol. 12. Date of Electronic Publication: 2024 Apr 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Actomyosin*/metabolism , Intercellular Adhesion Molecule-1*/genetics , Intercellular Adhesion Molecule-1*/metabolism, Animals ; Mice ; Humans ; Epithelial Cells/metabolism ; Hepatocytes/metabolism ; Liver/metabolism ; Actin Cytoskeleton/metabolism ; Leukocytes/metabolism ; Cell Polarity
مستخلص: Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, which are not accessible to circulating immune cells but that nevertheless confine most of ICAM-1. Here, by analyzing ICAM-1_KO human hepatic cells, liver organoids from ICAM-1_KO mice and rescue-of-function experiments, we show that ICAM-1 regulates epithelial apicobasal polarity in a leukocyte adhesion-independent manner. ICAM-1 signals to an actomyosin network at the base of canalicular microvilli, thereby controlling the dynamics and size of bile canalicular-like structures. We identified the scaffolding protein EBP50/NHERF1/SLC9A3R1, which connects membrane proteins with the underlying actin cytoskeleton, in the proximity interactome of ICAM-1. EBP50 and ICAM-1 form nano-scale domains that overlap in microvilli, from which ICAM-1 regulates EBP50 nano-organization. Indeed, EBP50 expression is required for ICAM-1-mediated control of BC morphogenesis and actomyosin. Our findings indicate that ICAM-1 regulates the dynamics of epithelial apical membrane domains beyond its role as a heterotypic cell-cell adhesion molecule and reveal potential therapeutic strategies for preserving epithelial architecture during inflammatory stress.
Competing Interests: CC, CL, NR, NC, AC, JC, SB, Gd, SC, AP, GD, CM, JF, GA, FM, PM, IC, JC, SN, MH, JM No competing interests declared
(© 2023, Cacho-Navas et al.)
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معلومات مُعتمدة: PID2020-119881RB-I00 Agencia Estatal de Investigación; P2022/BMD-7232 TomoXliver2 Comunidad de Madrid; IND2019/BMD-17139 Comunidad de Madrid; PID2021-125386NB-I00 Agencia Estatal de Investigación; 608765 Marie Skłodowska-Curie Actions; PID2022-137552OA-I00 Agencia Estatal de Investigación; RYC2021-031221-I Agencia Estatal de Investigación; Regulation EU 2020/2094 European Commission; PID2021-125386NB-I00 Fondo Europeo de Desarrollo Regional; FPI fellowship Ministry of Economy and Competitiveness; FPU fellowship Ministry of Education, Culture and Sports; Endocornea Convenio Colaboración CSIC Fundación Jiménez Díaz University Hospital Health Research Institute
فهرسة مساهمة: Keywords: EBP50/NHERF1/SLC9A3R1; ICAM-1; actomyosin; apicobasal polarity; cell biology; epithelial cells; human; immunology; inflammation; microvilli
المشرفين على المادة: 9013-26-7 (Actomyosin)
126547-89-5 (Intercellular Adhesion Molecule-1)
تواريخ الأحداث: Date Created: 20240410 Date Completed: 20240411 Latest Revision: 20240412
رمز التحديث: 20240412
مُعرف محوري في PubMed: PMC11006420
DOI: 10.7554/eLife.89261
PMID: 38597186
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.89261