دورية أكاديمية
Hippocampal acetylcholinesterase activation induced by streptozotocin in mice is protected by an organotellurium compound without evidence of toxicity.
| العنوان: | Hippocampal acetylcholinesterase activation induced by streptozotocin in mice is protected by an organotellurium compound without evidence of toxicity. |
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| المؤلفون: | Peixoto NC; Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil.; Departamento de Ciências da Saúde, Campus de Palmeira das Missões, Avenida Independência, 3751, Vista Alegre, 98300-000 Palmeira das Missões, RS, Brazil., Bernardi JS; Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Oliveira CS; Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Santos MSC; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Marion SL; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Silva RS; Programa de Pós-Graduação em Química, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Rosa RM; Programa de Pós-Graduação em Química, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Rodrigues OED; Programa de Pós-Graduação em Química, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil.; Departamento de Química, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Pereira ME; Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil.; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Campus Sede, Avenida Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil. |
| المصدر: | Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2024 Apr 08; Vol. 96 (1), pp. e20221048. Date of Electronic Publication: 2024 Apr 08 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academia Brasileira De Ciencias Country of Publication: Brazil NLM ID: 7503280 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-2690 (Electronic) Linking ISSN: 00013765 NLM ISO Abbreviation: An Acad Bras Cienc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rio De Janeiro : Academia Brasileira De Ciencias |
| مواضيع طبية MeSH: | Cognition Disorders*/chemically induced , Cognition Disorders*/drug therapy , Alzheimer Disease*/chemically induced , Alzheimer Disease*/drug therapy, Mice ; Animals ; Acetylcholinesterase/metabolism ; Streptozocin/toxicity ; Oxidative Stress ; Hippocampus ; Disease Models, Animal |
| مستخلص: | The cognitive deficit, which is like Alzheimer's disease and is associated with oxidative damage, may be induced by exposure to streptozotocin. This study aimed to evaluate if the tellurium-containing organocompound, 3j, 5'-arylchalcogeno-3-aminothymidine derivative, interferes with the effects of streptozotocin, as well as to investigate its toxicity in adult mice. Cognitive deficit was induced by two doses of streptozotocin (2.25 mg/kg/day, 48 h interval) intracerebroventricularly. After, the mice were subcutaneously treated with 3j (8.62 mg/kg/day) for 25 days. The effects were assessed by evaluating hippocampal and cortical acetylcholinesterase and behavioral tasks. 3j toxicity was investigated for 10 (0, 21.55, or 43.10 mg/kg/day) and 37 (0, 4.31, or 8.62 mg/kg/day) days by assessing biometric parameters and glucose and urea levels, and alanine aminotransferase activity in blood plasma. 3j exposure did not alter the behavioral alterations induced by streptozotocin exposure. On the other hand, 3j exposure normalized hippocampus acetylcholinesterase activity, which is enhanced by streptozotocin exposure. Toxicity evaluation showed that the administration of 3j for either 10 or 37 days did not cause harmful effects on the biometric and biochemical parameters analyzed. Therefore, 3j does not present any apparent toxicity and reverts acetylcholinesterase activity increase induced by streptozotocin in young adult mice. |
| التعليقات: | Erratum in: An Acad Bras Cienc. 2024 Aug 26;96(3):e20221048e. doi: 10.1590/0001-3765202420221048e. (PMID: 39194056) |
| المشرفين على المادة: | EC 3.1.1.7 (Acetylcholinesterase) 5W494URQ81 (Streptozocin) |
| تواريخ الأحداث: | Date Created: 20240410 Date Completed: 20240411 Latest Revision: 20240828 |
| رمز التحديث: | 20240828 |
| DOI: | 10.1590/0001-3765202420221048 |
| PMID: | 38597499 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-2690 |
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| DOI: | 10.1590/0001-3765202420221048 |