دورية أكاديمية
Role of adjuvant therapy in resected periampullary adenocarcinoma: A propensity matched case-control study.
| العنوان: | Role of adjuvant therapy in resected periampullary adenocarcinoma: A propensity matched case-control study. |
|---|---|
| المؤلفون: | Srivastava A; Department of Radiotherapy, Maulana Azad Medical College (MAMC), New Delhi, India., Nekarakanti PK; Department of GI Surgery, Govind Ballabh Pant Institute of Post graduate Medical Education & Research (GIPMER), New Delhi, India., Kanchodu S; Department of GI Surgery, Govind Ballabh Pant Institute of Post graduate Medical Education & Research (GIPMER), New Delhi, India., Srivastava S; Department of Gastro Medicine, Govind Ballabh Pant Institute of Post graduate Medical Education & Research (GIPMER), New Delhi, India., Mishra PK; Department of GI Surgery, Govind Ballabh Pant Institute of Post graduate Medical Education & Research (GIPMER), New Delhi, India., Saluja SS; Department of GI Surgery, Govind Ballabh Pant Institute of Post graduate Medical Education & Research (GIPMER), New Delhi, India. |
| المصدر: | Annals of hepato-biliary-pancreatic surgery [Ann Hepatobiliary Pancreat Surg] 2024 Apr 11. Date of Electronic Publication: 2024 Apr 11. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Association of Hepato-Biliary-Pancreatic Surgery Country of Publication: Korea (South) NLM ID: 101698342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2508-5859 (Electronic) Linking ISSN: 25085859 NLM ISO Abbreviation: Ann Hepatobiliary Pancreat Surg |
| أسماء مطبوعة: | Original Publication: [Seoul, Korea] : Korean Association of Hepato-Biliary-Pancreatic Surgery, [2016]- |
| مستخلص: | Backgrounds/aims: The published data had contradictory information on the role of adjuvant therapy on resected periampullary carcinomas (PACA). The study was performed to evaluate the survival benefit of adjuvant treatment. Methods: This was a propensity score matched case-control study from a prospectively maintained database from 2004-2019. The study included patients with nonpancreatic PACA who underwent curative resection. The patients (cases) who received adjuvant chemotherapy were compared with patients (controls) who were observed alone after surgery. Results: Of 510 patients with PACA, 230 patients (cases = 107, controls = 123) formed the unmatched study cohort. After propensity score matching, 140 patients (cases = 70, controls = 70) formed the matched study cohort. The median overall survival (OS) was similar in cases than controls in the unmatched population but doubled non-significantly in cases after matching (unmatched population, 54 months vs. 54 months, p -value = 0.624; matched population, 71 months vs. 36 months, p -value = 0.087). However, the median recurrence-free survival (RFS) was non significantly higher in the control group (unmatched population, 59 months vs. 38 months, p -value = 0.195; matched population, 53 months vs. 40 months, p -value = 0.797). In cox regression analysis, age < 60 years, advanced T stage, and presence of perineural invasion were independent factors for worse RFS, while tumor recurrence was an independent factor for poor OS. Conclusions: Patients with nonpancreatic PACA may have an OS benefit from adjuvant chemotherapy, and this needs to be validated with large prospective randomized studies. |
| فهرسة مساهمة: | Keywords: Adjuvant chemotherapy; Ampulla of Vater; Surgery |
| تواريخ الأحداث: | Date Created: 20240411 Latest Revision: 20240411 |
| رمز التحديث: | 20240411 |
| DOI: | 10.14701/ahbps.24-032 |
| PMID: | 38600673 |
| قاعدة البيانات: | MEDLINE |
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