دورية أكاديمية
Serum globulin in children with myasthenia gravis: predicting relapse and prognosis.
| العنوان: | Serum globulin in children with myasthenia gravis: predicting relapse and prognosis. |
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| المؤلفون: | Jiang Z; Department of Pediatrics, Jinan University First Affiliated Hospital, Guangzhou, China.; Department of Neurology, Hunan Children's Hospital, Changsha, China., Hu W; Department of Neurology, Hunan Children's Hospital, Changsha, China., Ning Z; Department of Neurology, Hunan Children's Hospital, Changsha, China., Wu L; Department of Neurology, Hunan Children's Hospital, Changsha, China., Yang L; Department of Neurology, Hunan Children's Hospital, Changsha, China., Liao H; Department of Neurology, Hunan Children's Hospital, Changsha, China., Chen B; Department of Neurology, Hunan Children's Hospital, Changsha, China., Tang J; Department of Neurology, Hunan Children's Hospital, Changsha, China., Xu R; Department of Neurology, Hunan Children's Hospital, Changsha, China., Guo F; Department of Neurology, Hunan Children's Hospital, Changsha, China., Liu S; Department of Neurology, Hunan Children's Hospital, Changsha, China. |
| المصدر: | Neurological research [Neurol Res] 2024 Jul; Vol. 46 (7), pp. 669-678. Date of Electronic Publication: 2024 Apr 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 7905298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-1328 (Electronic) Linking ISSN: 01616412 NLM ISO Abbreviation: Neurol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Abingdon : Taylor & Francis Original Publication: New York, Crane, Russak. |
| مواضيع طبية MeSH: | Myasthenia Gravis*/blood , Myasthenia Gravis*/diagnosis , Myasthenia Gravis*/drug therapy , Recurrence* , Serum Globulins*/analysis , Serum Globulins*/metabolism, Humans ; Male ; Female ; Child ; Retrospective Studies ; Prognosis ; Child, Preschool ; Adolescent ; Follow-Up Studies |
| مستخلص: | Objective: Serum globulin is associated with inflammatory or immune disorders. However, it has not been established whether it is associated with myasthenia gravis (MG). We investigated the association between globulin with relapse and prognosis in children with MG. Methods: A cohort of 148 MG cases and 150 healthy children were retrospectively enrolled from January 2015 to December 2021. Multivariate logistic and Cox regression models were used to analyze the treatment outcomes and recurrence of case group, exploring the influence of globulin. Results: Compared with the control group, globulin levels in the MG group were slightly increased ( t = 7.244, p < 0.001). After a mean follow-up of 2.25 ± 1.05 years, 35 cases relapsed, with a relapse rate of 23.65%. Logistic regression analysis showed that globulin levels at admission [adjusted odds ratio (OR) = 1.233, 95% confidence interval (CI) 1.028-1.472, p = 0.018] were independent risk factors for relapse. Cox regression analysis confirmed that globulin levels at admission affects relapse-free time [adjusted hazard ratio (HR) = 0.552, 95% CI 0.357-0.852, p = 0.007]. Receiver operating characteristic curve determined 25.10 as the optimal cutoff value for globulin. Cox regression showed that high globulin levels (>25.10) at admission (adjusted HR = 0.607, 95% CI 0.383-0.961, p = 0.033) were independent risk factors for poor therapeutic outcomes at follow-up. Ordinal logistic regression showed that globulin affects the treatment plan (OR = 1.445, 95% CI 1.223-1.847, p = 0.014). Conclusions: Elevated globulin levels in children with MG on admission predicts a high relapse rate and poor long-term therapeutic efficacies. |
| فهرسة مساهمة: | Keywords: Myasthenia gravis; children; globulin; prognostic outcomes; relapse; therapeutic efficacy Local Abstract: [plain-language-summary] Serum globulin in children with myasthenia gravis: predicting relapse and prognosisFirst, the globulin in the MG children was higher than in the healthy controls, and there was some correlation between the globulin and the level of systemic inflammation.Second, globulin has been associated with relapse of MG in children. The higher the globulin, the higher the relapse rate and the shorter the time to prevent a relapse.Third, both initial and final globulin were related to the effect of MG in children, and the higher the long-term effect, the worse the long-term effect. It also influenced the change in treatment plan. |
| المشرفين على المادة: | 0 (Serum Globulins) |
| تواريخ الأحداث: | Date Created: 20240411 Date Completed: 20240529 Latest Revision: 20240529 |
| رمز التحديث: | 20240530 |
| DOI: | 10.1080/01616412.2024.2340883 |
| PMID: | 38602312 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1743-1328 |
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| DOI: | 10.1080/01616412.2024.2340883 |