دورية أكاديمية
Pick a PACC: Comparing domain-specific and general cognitive composites in Alzheimer disease research.
| العنوان: | Pick a PACC: Comparing domain-specific and general cognitive composites in Alzheimer disease research. |
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| المؤلفون: | McKay NS; Mallinckrodt Institute of Radiology, Washington University School of Medicine., Millar PR; Department of Neurology, Washington University School of Medicine., Nicosia J; Department of Neurology, Washington University School of Medicine., Aschenbrenner AJ; Department of Neurology, Washington University School of Medicine., Gordon BA; Mallinckrodt Institute of Radiology, Washington University School of Medicine., Benzinger TLS; Mallinckrodt Institute of Radiology, Washington University School of Medicine., Cruchaga CC; Department of Psychiatry, Washington University School of Medicine., Schindler SE; Department of Neurology, Washington University School of Medicine., Morris JC; Department of Neurology, Washington University School of Medicine., Hassenstab J; Department of Neurology, Washington University School of Medicine. |
| المصدر: | Neuropsychology [Neuropsychology] 2024 Jul; Vol. 38 (5), pp. 443-464. Date of Electronic Publication: 2024 Apr 11. |
| نوع المنشور: | Journal Article; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Psychological Association Country of Publication: United States NLM ID: 8904467 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-1559 (Electronic) Linking ISSN: 08944105 NLM ISO Abbreviation: Neuropsychology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Psychological Association Original Publication: Philadelphia, PA : Philadelphia Clinical Neuropsychology Group, c1987- |
| مواضيع طبية MeSH: | Alzheimer Disease*/psychology , Neuropsychological Tests*, Humans ; Female ; Male ; Aged ; Aged, 80 and over ; Attention/physiology ; Middle Aged ; Memory, Episodic ; Memory, Short-Term/physiology ; Cognition/physiology ; Cognitive Dysfunction/diagnosis |
| مستخلص: | Objective: We aimed to illustrate how complex cognitive data can be used to create domain-specific and general cognitive composites relevant to Alzheimer disease research. Method: Using equipercentile equating, we combined data from the Charles F. and Joanne Knight Alzheimer Disease Research Center that spanned multiple iterations of the Uniform Data Set. Exploratory factor analyses revealed four domain-specific composites representing episodic memory, semantic memory, working memory, and attention/processing speed. The previously defined preclinical Alzheimer disease cognitive composite (PACC) and a novel alternative, the Knight-PACC, were also computed alongside a global composite comprising all available tests. These three composites allowed us to compare the usefulness of domain and general composites in the context of predicting common Alzheimer disease biomarkers. Results: General composites slightly outperformed domain-specific metrics in predicting imaging-derived amyloid, tau, and neurodegeneration burden. Power analyses revealed that the global, Knight-PACC, and attention and processing speed composites would require the smallest sample sizes to detect cognitive change in a clinical trial, while the Alzheimer Disease Cooperative Study-PACC required two to three times as many participants. Conclusions: Analyses of cognition with the Knight-PACC and our domain-specific composites offer researchers flexibility by providing validated outcome assessments that can equate across test versions to answer a wide range of questions regarding cognitive decline in normal aging and neurodegenerative disease. (PsycInfo Database Record (c) 2024 APA, all rights reserved). |
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| معلومات مُعتمدة: | P30 AG066444 United States AG NIA NIH HHS; P01 AG026276 United States AG NIA NIH HHS; United States NH NIH HHS; P01 AG003991 United States AG NIA NIH HHS; BrightFocus Foundation; United States ALZ Alzheimer's Association; United States NH NIH HHS |
| تواريخ الأحداث: | Date Created: 20240411 Date Completed: 20240613 Latest Revision: 20240725 |
| رمز التحديث: | 20240726 |
| مُعرف محوري في PubMed: | PMC11176005 |
| DOI: | 10.1037/neu0000949 |
| PMID: | 38602816 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1931-1559 |
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| DOI: | 10.1037/neu0000949 |