دورية أكاديمية
Information flow between motor cortex and striatum reverses during skill learning.
| العنوان: | Information flow between motor cortex and striatum reverses during skill learning. |
|---|---|
| المؤلفون: | Lemke SM; Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Corso Bettini 31, 38068 Rovereto, Italy; Neurology Service, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA; Department of Neurology, University of California, San Francisco, 1700 Owens Street, San Francisco, CA 94158, USA; Neuroscience Center, University of North Carolina, Chapel Hill, 116 Manning Drive, Chapel Hill, NC 27599, USA. Electronic address: stefan.lemke@unc.edu., Celotto M; Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Corso Bettini 31, 38068 Rovereto, Italy; Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy; Institute of Neural Information Processing, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany., Maffulli R; Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Corso Bettini 31, 38068 Rovereto, Italy., Ganguly K; Neurology Service, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA; Department of Neurology, University of California, San Francisco, 1700 Owens Street, San Francisco, CA 94158, USA., Panzeri S; Institute of Neural Information Processing, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany. Electronic address: s.panzeri@uke.de. |
| المصدر: | Current biology : CB [Curr Biol] 2024 May 06; Vol. 34 (9), pp. 1831-1843.e7. Date of Electronic Publication: 2024 Apr 10. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: London, UK : Current Biology Ltd., c1991- |
| مواضيع طبية MeSH: | Motor Cortex*/physiology , Learning*/physiology , Corpus Striatum*/physiology , Rats, Long-Evans* , Motor Skills*/physiology, Animals ; Rats ; Male |
| مستخلص: | The coordination of neural activity across brain areas during a specific behavior is often interpreted as neural communication involved in controlling the behavior. However, whether information relevant to the behavior is actually transferred between areas is often untested. Here, we used information-theoretic tools to quantify how motor cortex and striatum encode and exchange behaviorally relevant information about specific reach-to-grasp movement features during skill learning in rats. We found a temporal shift in the encoding of behaviorally relevant information during skill learning, as well as a reversal in the primary direction of behaviorally relevant information flow, from cortex-to-striatum during naive movements to striatum-to-cortex during skilled movements. Standard analytical methods that quantify the evolution of overall neural activity during learning-such as changes in neural signal amplitude or the overall exchange of information between areas-failed to capture these behaviorally relevant information dynamics. Using these standard methods, we instead found a consistent coactivation of overall neural signals during movement production and a bidirectional increase in overall information propagation between areas during learning. Our results show that skill learning is achieved through a transformation in how behaviorally relevant information is routed across cortical and subcortical brain areas and that isolating the components of neural activity relevant to and informative about behavior is critical to uncover directional interactions within a coactive and coordinated network. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | R01 NS108410 United States NS NINDS NIH HHS; R01 NS109961 United States NS NINDS NIH HHS; U19 NS107464 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Keywords: information flow; information theory; motor control; motor cortex; partial information decomposition; skill learning; striatum |
| تواريخ الأحداث: | Date Created: 20240411 Date Completed: 20240507 Latest Revision: 20240523 |
| رمز التحديث: | 20240524 |
| مُعرف محوري في PubMed: | PMC11078609 |
| DOI: | 10.1016/j.cub.2024.03.023 |
| PMID: | 38604168 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1879-0445 |
|---|---|
| DOI: | 10.1016/j.cub.2024.03.023 |