دورية أكاديمية
The Repeatability of Pharyngeal Opening Pressure Under Drug-Induced Sleep Endoscopy.
| العنوان: | The Repeatability of Pharyngeal Opening Pressure Under Drug-Induced Sleep Endoscopy. |
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| المؤلفون: | Chan TG; Emory University School of Medicine, Atlanta, Georgia, USA., Plageman J; Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, Georgia, USA., Yu JL; Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, Georgia, USA. |
| المصدر: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2024 Jul; Vol. 171 (1), pp. 295-302. Date of Electronic Publication: 2024 Apr 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 8508176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6817 (Electronic) Linking ISSN: 01945998 NLM ISO Abbreviation: Otolaryngol Head Neck Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [Oxford] : Wiley Original Publication: [Rochester, Minn.] : The Academy, [c1981- |
| مواضيع طبية MeSH: | Continuous Positive Airway Pressure* , Pharynx* , Sleep Apnea, Obstructive*/therapy , Sleep Apnea, Obstructive*/physiopathology , Endoscopy*/methods, Humans ; Male ; Female ; Prospective Studies ; Middle Aged ; Reproducibility of Results ; Pressure ; Adult ; Aged ; Polysomnography ; Hypnotics and Sedatives/administration & dosage |
| مستخلص: | Objective: Pharyngeal opening pressure (PhOP) is a measure of upper airway collapsibility that can be obtained during drug-induced sleep endoscopy (DISE) using a continuous positive airway pressure (CPAP) titration. However, the stability of PhOP over the course of sedation during DISE remains unclear. This study aims to compare repeat measures of PhOP over the course of DISE. Study Design: Single arm prospective study. Setting: Single tertiary care institution. Methods: Patients had 2 CPAP titrations while undergoing DISE. Collected data included patient demographics, PhOP, patient sedation index (PSI), and duration of and between CPAP titrations. t Tests, test-retest coefficient analysis, and repeated measures correlation were performed. Results: Twenty-five patients completed the study between 2022 and 2023 with 22 patients having sedation depth (PSI) recording. Most were male (76%), obese (average body mass index: 30.24 kg/m 2 ), with severe obstructive sleep apnea (average apnea-hypopnea index: 39.8 events/hr). Test-retest analysis showed good-excellent correlation between PhOP values (intraclass correlation coefficient = 0.892, P < .0001, n = 25). Average time between CPAP titrations was 15 minutes to 6 seconds. Over that time, PhOP increased by an average of 0.72 cmH Conclusion: The results showed repeatability of PhOP values over the course of DISE. When adjusted for sedation depth (PSI), deeper sedation was weakly associated with greater PHOP. However, the magnitude of this change was small and we conclude that PhOP remains relatively stable over the course of DISE (Effects of Lung Volume on Upper Airway Patency During DISE [DISE-Pulm], NCT05350332, clinicaltrials.gov). (© 2024 American Academy of Otolaryngology–Head and Neck Surgery Foundation.) |
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| معلومات مُعتمدة: | KL2 TR002381 United States TR NCATS NIH HHS; UL1 TR002378 United States TR NCATS NIH HHS |
| فهرسة مساهمة: | Keywords: drug‐induced sleep endoscopy; obstructive sleep apnea; pharyngeal opening pressure; repeatable measures; upper airway collapsibility |
| سلسلة جزيئية: | ClinicalTrials.gov NCT05350332 |
| المشرفين على المادة: | 0 (Hypnotics and Sedatives) |
| تواريخ الأحداث: | Date Created: 20240412 Date Completed: 20240627 Latest Revision: 20240712 |
| رمز التحديث: | 20240712 |
| مُعرف محوري في PubMed: | PMC11211064 |
| DOI: | 10.1002/ohn.730 |
| PMID: | 38606621 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-6817 |
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| DOI: | 10.1002/ohn.730 |