دورية أكاديمية
Genome Mining Reveals a UbiA-Type Prenyltransferase Access to Farnesylation of Diketopiperazines.
| العنوان: | Genome Mining Reveals a UbiA-Type Prenyltransferase Access to Farnesylation of Diketopiperazines. |
|---|---|
| المؤلفون: | Yu X; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China., Ma C; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China., Wang W; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China., Ge J; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China., Wang Z; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China., Lin J; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China., Che Q; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China., Zhang G; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.; Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao 266237, People's Republic of China., Zhu T; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.; Sanya Oceanographic Institute, Ocean University of China, Sanya 572025, People's Republic of China., Li D; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.; Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao 266237, People's Republic of China.; Sanya Oceanographic Institute, Ocean University of China, Sanya 572025, People's Republic of China. |
| المصدر: | Organic letters [Org Lett] 2024 Apr 26; Vol. 26 (16), pp. 3349-3354. Date of Electronic Publication: 2024 Apr 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c1999- |
| مواضيع طبية MeSH: | Dimethylallyltranstransferase*/metabolism , Dimethylallyltranstransferase*/chemistry , Dimethylallyltranstransferase*/genetics , Diketopiperazines*/chemistry , Diketopiperazines*/metabolism , Prenylation*, Molecular Structure ; Multigene Family |
| مستخلص: | UbiA-type prenyltransferases (PTases) are significant enzymes that lead to structurally diverse meroterpenoids. Herein, we report the identification and characterization of an undescribed UbiA-type PTase, FtaB, that is responsible for the farnesylation of indole-containing diketopiperazines (DKPs) through genome mining. Heterologous expression of the fta gene cluster and non-native pathways result in the production of a series of new C2 -farnesylated DKPs. This study broadens the reaction scope of UbiA-type PTases and expands the chemical diversity of meroterpenoids. |
| المشرفين على المادة: | EC 2.5.1.1 (Dimethylallyltranstransferase) 0 (Diketopiperazines) |
| تواريخ الأحداث: | Date Created: 20240412 Date Completed: 20240426 Latest Revision: 20240430 |
| رمز التحديث: | 20240430 |
| DOI: | 10.1021/acs.orglett.4c00714 |
| PMID: | 38607994 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1523-7052 |
|---|---|
| DOI: | 10.1021/acs.orglett.4c00714 |