دورية أكاديمية
Preparation of Simple Bicyclic Carboxylate-Rich Alicyclic Molecules for the Investigation of Dissolved Organic Matter.
| العنوان: | Preparation of Simple Bicyclic Carboxylate-Rich Alicyclic Molecules for the Investigation of Dissolved Organic Matter. |
|---|---|
| المؤلفون: | Craig AJ; Analytical Chemistry, Department of Chemistry BMC, Uppsala University, Uppsala 752 37, Sweden.; Drug Design and Discovery, Department of Medicinal Chemistry, Uppsala University, Uppsala 752 37, Sweden., Moodie LWK; Drug Design and Discovery, Department of Medicinal Chemistry, Uppsala University, Uppsala 752 37, Sweden., Hawkes JA; Analytical Chemistry, Department of Chemistry BMC, Uppsala University, Uppsala 752 37, Sweden. |
| المصدر: | Environmental science & technology [Environ Sci Technol] 2024 Apr 23; Vol. 58 (16), pp. 7078-7086. Date of Electronic Publication: 2024 Apr 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: In Process; MEDLINE |
| أسماء مطبوعة: | Publication: Washington DC : American Chemical Society Original Publication: Easton, Pa. : American Chemical Society, c1967- |
| مستخلص: | Dissolved organic matter (DOM) is a vast and complex chemical mixture that plays a key role in the mediation of the global carbon cycle. Fundamental understanding of the source and fate of oceanic organic matter is obscured due to poor definition of the key molecular contributors to DOM, which limits accurate sample analysis and prediction of the Earth's carbon cycle. Previous work has attempted to define the components of the DOM through a variety of chromatographic and spectral techniques. However, modern preparative and analytical methods have not isolated or unambiguously identified molecules from DOM. Therefore, previously proposed structures are based solely on the mixture's aggregate properties and do not accurately describe any true individual molecular component. In addition to this, there is a lack of appropriate analogues of the individual chemical classes within DOM, limiting the scope of experiments that probe the physical, chemical, and biological contributions from each class. To address these problems, we synthesized a series of analogues of carboxylate-rich alicyclic molecules (CRAM), a molecular class hypothesized to exist as a major contributor to DOM. Key analytical features of the synthetic CRAMs were consistent with marine DOM, supporting their suitability as chemical substitutes for CRAM. This new approach provides access to a molecular toolkit that will enable previously inaccessible experiments to test many unproven hypotheses surrounding the ever-enigmatic DOM. |
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| فهرسة مساهمة: | Keywords: Diels−Alder reaction; carboxylate-rich alicyclic molecules; dissolved organic matter; mass spectrometry; nuclear magnetic resonance; synthesis |
| تواريخ الأحداث: | Date Created: 20240412 Latest Revision: 20240427 |
| رمز التحديث: | 20240427 |
| مُعرف محوري في PubMed: | PMC11044592 |
| DOI: | 10.1021/acs.est.4c00166 |
| PMID: | 38608252 |
| قاعدة البيانات: | MEDLINE |
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