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Temporal Alterations in Cerebrovascular Glycocalyx and Cerebral Blood Flow after Exposure to a High-Intensity Blast in Rats.

التفاصيل البيبلوغرافية
العنوان: Temporal Alterations in Cerebrovascular Glycocalyx and Cerebral Blood Flow after Exposure to a High-Intensity Blast in Rats.
المؤلفون: Chen Y; Naval Medical Research Command, Silver Spring, MD 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA., Gu M; Naval Medical Research Command, Silver Spring, MD 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA., Patterson J; Naval Medical Research Command, Silver Spring, MD 20910, USA.; Parsons Corporation, Columbia, MD 21046, USA., Zhang R; Naval Medical Research Command, Silver Spring, MD 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA., Statz JK; Naval Medical Research Command, Silver Spring, MD 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA., Reed E; Naval Medical Research Command, Silver Spring, MD 20910, USA.; Parsons Corporation, Columbia, MD 21046, USA., Abutarboush R; Naval Medical Research Command, Silver Spring, MD 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA., Ahlers ST; Naval Medical Research Command, Silver Spring, MD 20910, USA., Kawoos U; Naval Medical Research Command, Silver Spring, MD 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 22; Vol. 25 (7). Date of Electronic Publication: 2024 Mar 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Syndecan-2* , Heparan Sulfate Proteoglycans*, Animals ; Rats ; Glycocalyx ; Hypercapnia ; Cerebrovascular Circulation ; Heparitin Sulfate ; Chondroitin Sulfates
مستخلص: The glycocalyx is a proteoglycan-glycoprotein structure lining the luminal surface of the vascular endothelium and is susceptible to damage due to blast overpressure (BOP) exposure. The glycocalyx is essential in maintaining the structural and functional integrity of the vasculature and regulation of cerebral blood flow (CBF). Assessment of alterations in the density of the glycocalyx; its components (heparan sulphate proteoglycan (HSPG/syndecan-2), heparan sulphate (HS), and chondroitin sulphate (CS)); CBF; and the effect of hypercapnia on CBF was conducted at 2-3 h, 1, 3, 14, and 28 days after a high-intensity (18.9 PSI/131 kPa peak pressure, 10.95 ms duration, and 70.26 PSI·ms/484.42 kPa·ms impulse) BOP exposure in rats. A significant reduction in the density of the glycocalyx was observed 2-3 h, 1-, and 3 days after the blast exposure. The glycocalyx recovered by 28 days after exposure and was associated with an increase in HS (14 and 28 days) and in HSPG/syndecan-2 and CS (28 days) in the frontal cortex. In separate experiments, we observed significant decreases in CBF and a diminished response to hypercapnia at all time points with some recovery at 3 days. Given the role of the glycocalyx in regulating physiological function of the cerebral vasculature, damage to the glycocalyx after BOP exposure may result in the onset of pathogenesis and progression of cerebrovascular dysfunction leading to neuropathology.
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معلومات مُعتمدة: work unit number 603115HP.3520.001.A1411. United States Department of Defense
فهرسة مساهمة: Keywords: blast; cerebral blood flow; cerebrovascular glycocalyx; traumatic brain injury; vascular pathology
المشرفين على المادة: 149769-25-5 (Syndecan-2)
0 (Heparan Sulfate Proteoglycans)
9050-30-0 (Heparitin Sulfate)
9007-28-7 (Chondroitin Sulfates)
تواريخ الأحداث: Date Created: 20240413 Date Completed: 20240415 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11011510
DOI: 10.3390/ijms25073580
PMID: 38612392
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25073580