دورية أكاديمية
Age and aging process alter the gut microbes.
| العنوان: | Age and aging process alter the gut microbes. |
|---|---|
| المؤلفون: | Zhanbo Q; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.; Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou 313000, Zhejiang, China.; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou 313000, Zhejiang, China., Jing Z; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.; Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou 313000, Zhejiang, China.; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou 313000, Zhejiang, China., Shugao H; The Second Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou 310017, Zhejiang, China., Yinhang W; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.; Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou 313000, Zhejiang, China.; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou 313000, Zhejiang, China., Jian C; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.; Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou 313000, Zhejiang, China.; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou 313000, Zhejiang, China., Xiang Y; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.; Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou 313000, Zhejiang, China.; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou 313000, Zhejiang, China., Feimin Z; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.; Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou 313000, Zhejiang, China.; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou 313000, Zhejiang, China., Jian L; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.; Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou 313000, Zhejiang, China.; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou 313000, Zhejiang, China., Xinyue W; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China., Wei W; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.; Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou 313000, Zhejiang, China.; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou 313000, Zhejiang, China., Shuwen H; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.; Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou 313000, Zhejiang, China.; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou 313000, Zhejiang, China. |
| المصدر: | Aging [Aging (Albany NY)] 2024 Apr 08; Vol. 16 (8), pp. 6839-6851. Date of Electronic Publication: 2024 Apr 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, NY : Impact Journals, LLC |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome* , Aging*/physiology , Feces*/microbiology, Humans ; Middle Aged ; Aged ; Male ; Female ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Age Factors ; Aged, 80 and over |
| مستخلص: | Background: Gut microbes and age are both factors that influence the development of disease. The community structure of gut microbes is affected by age. Objective: To plot time-dependent gut microbe profiles in individuals over 45 years old and explore the correlation between age and gut microbes. Methods: Fecal samples were collected from 510 healthy individuals over 45 years old. Shannon index, Simpson index, Ace index, etc. were used to analyze the diversity of gut microbes. The beta diversity analysis, including non-metric multidimensional scaling (NMDS), was used to analyze community distribution. Linear discriminant analysis (LDA) and random forest (RF) algorithm were used to analyze the differences of gut microbes. Trend analysis was used to plot the abundances of characteristic gut microbes in different ages. Results: The individuals aged 45-49 had the highest richness of gut bacteria. Fifteen characteristic gut microbes, including Siphoviridae and Bifidobacterium breve , were screened by RF algorithm. The abundance of Ligiactobacillus and Microviridae were higher in individuals older than 65 years. Moreover, the abundance of Blautia_A massiliensis , Lubbockvirus and Enterocloster clostridioformis decreased with age and the abundance of Klebsiella variicola and Prevotell a increased with age. The functional genes, such as human diseases and aging, were significantly different among different aged individuals. Conclusions: The individuals in different ages have characteristic gut microbes. The changes in community structure of gut microbes may be related to age-induced diseases. |
| References: | Surg Clin North Am. 2022 Jun;102(3):499-516. (PMID: 35671770) Cancer Sci. 2023 Mar;114(3):1118-1130. (PMID: 36398663) Gut Microbes. 2018 Jul 4;9(4):308-325. (PMID: 29667480) Viruses. 2019 Jul 18;11(7):. (PMID: 31323792) Int J Syst Evol Microbiol. 2020 Jan;70(1):23-34. (PMID: 31782700) Br J Nutr. 2017 Jan;117(1):93-107. (PMID: 28102115) Nutrients. 2021 Sep 26;13(10):. (PMID: 34684377) Molecules. 2020 Dec 08;25(24):. (PMID: 33302541) EBioMedicine. 2020 Feb;52:102649. (PMID: 32062353) Mucosal Immunol. 2021 May;14(3):555-565. (PMID: 33542493) Rheumatology (Oxford). 2021 Jun 18;60(6):e203-e204. (PMID: 33320244) Gut Microbes. 2021 Jan-Dec;13(1):1-21. (PMID: 33525961) J Clin Virol. 2019 Dec;121:104205. (PMID: 31722268) Cardiovasc Diabetol. 2021 Jan 22;20(1):24. (PMID: 33482830) BMC Microbiol. 2019 Oct 28;19(1):236. (PMID: 31660868) Curr Opin Virol. 2021 Apr;47:86-94. (PMID: 33652230) Viruses. 2021 Jan 13;13(1):. (PMID: 33451106) Gastroenterology. 2021 Jan;160(2):507-523. (PMID: 33307030) Lancet Infect Dis. 2022 Jan;22(1):e35-e40. (PMID: 34265258) Am J Med. 2019 Jul;132(7):802-807. (PMID: 30890425) Lancet. 2003 Feb 8;361(9356):512-9. (PMID: 12583961) BMC Microbiol. 2016 May 25;16:90. (PMID: 27220822) Nat Rev Microbiol. 2022 Dec;20(12):737-749. (PMID: 35773472) Biomed Pharmacother. 2020 Jan;121:109550. (PMID: 31704617) Science. 2011 Oct 14;334(6053):249-52. (PMID: 21998395) Anaerobe. 2014 Aug;28:149-56. (PMID: 24933584) Nutrients. 2023 Mar 30;15(7):. (PMID: 37049541) Kidney Int. 2022 Jan;101(1):36-46. (PMID: 34757122) Pediatr Clin North Am. 2015 Feb;62(1):201-23. (PMID: 25435120) World J Gastroenterol. 2014 Jan 7;20(1):91-9. (PMID: 24415861) Int J Syst Evol Microbiol. 2019 Jan;69(1):33-38. (PMID: 30407903) J Virol. 2019 Nov 13;93(23):. (PMID: 31511379) Food Funct. 2019 Mar 20;10(3):1736-1746. (PMID: 30855043) Curr Hypertens Rep. 2021 Sep 6;23(8):40. (PMID: 34487269) Expert Rev Gastroenterol Hepatol. 2019 Jan;13(1):3-15. (PMID: 30791839) Gastroenterology. 2020 Jan;158(2):322-340. (PMID: 31586566) Nature. 2012 Sep 13;489(7415):220-30. (PMID: 22972295) Cell Host Microbe. 2020 Nov 11;28(5):724-740.e8. (PMID: 32841606) Aging Cell. 2017 Aug;16(4):624-633. (PMID: 28544158) PLoS One. 2022 Mar 15;17(3):e0265430. (PMID: 35290412) Nat Rev Immunol. 2023 Jan;23(1):9-23. (PMID: 35534624) Phytomedicine. 2021 Dec;93:153772. (PMID: 34753028) Microbes Infect. 2021 Jul-Aug;23(6-7):104849. (PMID: 34146716) Nature. 2012 Sep 13;489(7415):242-9. (PMID: 22972297) Nutrients. 2019 Nov 07;11(11):. (PMID: 31703257) Curr Opin Rheumatol. 2016 Jul;28(4):383-9. (PMID: 27166925) Front Immunol. 2023 Jan 19;14:1096323. (PMID: 36742327) Sci Immunol. 2022 Apr 8;7(70):eabn6660. (PMID: 35394816) Gut. 2022 May;71(5):1020-1032. (PMID: 35105664) Appl Microbiol Biotechnol. 2021 Nov;105(21-22):8427-8440. (PMID: 34625821) |
| فهرسة مساهمة: | Keywords: age; bioinformatics analysis; functional genes; gut microbes; metagenomic sequencing |
| تواريخ الأحداث: | Date Created: 20240413 Date Completed: 20240506 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| مُعرف محوري في PubMed: | PMC11087091 |
| DOI: | 10.18632/aging.205728 |
| PMID: | 38613799 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!